Decoding marker genes and immune landscape of unstable carotid plaques from cellular senescence.

Recently, cellular senescence-induced unstable carotid plaques have gained increasing attention. In this study, we utilized bioinformatics and machine learning methods to investigate the correlation between cellular senescence and the pathological mechanisms of unstable carotid plaques. Our aim was to elucidate the causes of unstable carotid plaque progression and identify new therapeutic strategies.

Bidirectionally promoting assembly order for ultrastiff and highly thermally conductive graphene fibres.

Macroscopic fibres assembled from two-dimensional (2D) nanosheets are new and impressing type of fibre materials besides those from one-dimensional (1D) polymers, such as graphene fibres. However, the preparation and property-enhancing technologies of these fibres follow those from 1D polymers by improving the orientation along the fibre axis, leading to non-optimized microstructures and low integrated performances. Here, we show a concept of bidirectionally promoting the assembly order, making graphene fibres achieve synergistically improved mechanical and thermal properties.

Falling-Leaves Stacking Aggregation of Two-Dimensional Macromolecular Graphene Oxide in Solution.

Understanding the dynamical behaviors of two-dimensional (2D) macromolecules is of fundamental importance for the precise modulation of their assembled structures and material performances. However, considerably less is known about how discrete macromolecular sheets aggregate into extended macroscopic assemblies in solutions. The absence of a quantitative description of the assembly process limits the precise structural control of assemblies.

Superior Strong and Tough Nacre-Inspired Materials by Interlayer Entanglement.

Natural materials teach that mechanical dissipative interactions relieve the conflict between strength and toughness and enable fabrication of strong yet tough artificial materials. Replicating natural nacre structure has yielded rich biomimetic materials; however, stronger interlayer dissipation still waits to be exploited to extend the performance limits of artificial nacre materials. Here, we introduce strong entanglement as a new artificial interlayer dissipative mechanism and fabricate entangled nacre materials with superior strength and toughness, across molecular to nanoscale nacre structures.

Novel combination of paraspinal keyhole surgery with a tubular retractor system leads to significant improvements in lumbar intraspinal extramedullary schwannomas.

The aim of the present study was to investigate the efficacy of combining paraspinal keyhole surgery with a tubular retractor system for the microsurgical removal of lumbar intraspinal extramedullary schwannomas. A retrospective analysis was conducted of 56 patients with lumbar intraspinal extramedullary schwannomas who were treated using the microsurgical paraspinal keyhole approach with a tubular retractor system. The mean ± standard deviation was calculated for the following parameters: Surgery time (96.

A reproducible model of intramedullary spinal cord tumor in rats bearing RG2 cells.

Intramedullary spinal cord tumors (IMSCTs) are lethal diseases to many patients. The lack of adequate animal model has hampered the development of novel treatments. In the current study, a rodent intramedullary glioma model is established to study IMSCT progression.

Spontaneous spinal epidural hematoma management with minimally invasive surgery through tubular retractors: A case report and review of the literature.

To report a minimally invasive paraspinal approach in the treatment of a case of spontaneous spinal epidural hematoma (SSEH). We additionally aim to review the relevant literature to enhance our knowledge of this disease. SSEH is an uncommon but potentially catastrophic disease.

[Microsurgical resection of lumbar intraspinal tumors through paraspinal approach using percutaneous tubular retractor system].

Objective: To evaluate the clinical outcomes and operative techniques of microsurgical resection of lumbar intraspinal tumors through paraspinal approach by percutaneous tubular retractor system.

Methods: A retrospective study was conducted to analyze 21 patients with lumbar intraspinal tumors between November 2011 and February 2014, including Schwannoma (n = 19) and meningioma (n = 2) without lumbar instability on preoperative images. The length of tumors was 0.

Poly(-acylethylenimine) copolymers containing pendant pentamethyldisiloxanyl groups. I. Synthesis.

10-(Pentamethyl disiloxanyl) decyl oxazoline () was synthesized. It was copolymerized with either undecyl () or nonyl () oxazolines using methyl 4-nitrobenzenesulfonate as initiator. Two series of random poly(-acylethylenimine) copolymers, and , were synthesized over the whole composition range of monomer with a total degree of polymerization of about 100.