Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset.

The Alzheimer's Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Alzheimer's Disease and Related Dementias (AD/ADRD) by sequencing whole genomes of affected participants and age-matched cognitive controls from diverse populations. The Genome Center for Alzheimer's Disease (GCAD) processed whole-genome sequencing data from 36,361 ADSP participants, including 35,014 genetically unique participants of which 45% are from non-European ancestry, across 17 cohorts in 14 countries in this fourth release (R4). This sequencing effort identified 387 million bi-allelic variants, 42 million short insertions/deletions, and 2.

NIAGADS: A Comprehensive National Data Repository for Alzheimer's Disease and Related Dementia Genetics and Genomics Research.

NIAGADS is the National Institute on Aging (NIA) designated national data repository for human genetics research on Alzheimer's Disease and related dementia (ADRD). NIAGADS maintains a high-quality data collection for ADRD genetic/genomic research and supports genetics data production and analysis. NIAGADS hosts whole genome and exome sequence data from the Alzheimer's Disease Sequencing Project (ADSP) and other genotype/phenotype data, encompassing 209,000 samples.

Human whole-exome genotype data for Alzheimer's disease.

The heterogeneity of the whole-exome sequencing (WES) data generation methods present a challenge to a joint analysis. Here we present a bioinformatics strategy for joint-calling 20,504 WES samples collected across nine studies and sequenced using ten capture kits in fourteen sequencing centers in the Alzheimer's Disease Sequencing Project. The joint-genotype called variant-called format (VCF) file contains only positions within the union of capture kits.

NIAGADS Alzheimer's GenomicsDB: A resource for exploring Alzheimer's disease genetic and genomic knowledge.

Introduction: The National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site Alzheimer's Genomics Database (GenomicsDB) is a public knowledge base of Alzheimer's disease (AD) genetic datasets and genomic annotations.

Methods: GenomicsDB uses a custom systems architecture to adopt and enforce rigorous standards that facilitate harmonization of AD-relevant genome-wide association study summary statistics datasets with functional annotations, including over 230 million annotated variants from the AD Sequencing Project.

Results: GenomicsDB generates interactive reports compiled from the harmonized datasets and annotations.

Improved defluoridation and energy production using dimethyl sulfoxide modified carbon cloth as bioanode in microbial desalination cell.

In the present study, carbon cloth (CC) was functionalized using dimethyl sulfoxide (DMSO) and employed as an excellent bioanode for improving defluoridation efficiency, wastewater treatment, and power output from a microbial desalination cell (MDC). The Raman spectroscopy and X-ray photoelectron spectroscopy (XPS) analysis of DMSO modified carbon cloth (CC) confirmed the functionalization of CC, and the water drop contact angle of 0° ensured its superior hydrophilicity. The presence of -COOH (carboxyl), S[bond, double bond]O (sulfoxide) and -C[bond, double bond]O (carbonyl) functional groups on CC aids in enhancing the performance of the MDC.

Trends, Extreme Events and Long-term Health Impacts of Particulate Matter in a Southern Indian Industrial Area.

Unlabelled: The present study uses various statistical tools to understand the behaviour of PM and PM in the Kanjikode industrial area of Southern India. Annual PM and PM average concentrations in 2018-2020 were three times more than the World Health Organization-specified standards (5 and 15 µg m). The statistical distribution analysis suggested well-fitted lognormal and gamma distributions of 24-h average PM concentrations and gamma distributions of 24-h average PM concentrations.

A flexible and sensitive electrochemical sensing platform based on dimethyl sulfoxide modified carbon cloth: towards the detection of dopamine and carvedilol.

The determination of neurotransmitters and adrenoreceptor drugs is highly essential due to their specific functions in the human body. In this work, the determination of carvedilol (CAR) and dopamine (DA) was carried out using carbon cloth (CC), which was modified using a facile strategy of drop-casting dimethyl sulfoxide (DMSO). This induced the formation of functional groups without any loss in the structural integrity of CC.

FILER: a framework for harmonizing and querying large-scale functional genomics knowledge.

Querying massive functional genomic and annotation data collections, linking and summarizing the query results across data sources/data types are important steps in high-throughput genomic and genetic analytical workflows. However, these steps are made difficult by the heterogeneity and breadth of data sources, experimental assays, biological conditions/tissues/cell types and file formats. FILER (FunctIonaL gEnomics Repository) is a framework for querying large-scale genomics knowledge with a large, curated integrated catalog of harmonized functional genomic and annotation data coupled with a scalable genomic search and querying interface.

Concentrating nutrients and recovering water and energy from source separated urine using osmotic microbial fuel cell.

This work presents the use of osmotic microbial fuel cell (OsMFC), for the first time, to concentrate nutrients and recover water and energy from source separated urine. Four sets of concentration of fresh urine as feed and NaCl as draw were examined: 10% fresh urine vs 0.25 M NaCl; 10% fresh urine vs 2 M NaCl; fresh urine vs 0.

Toward pH Independent Oxygen Reduction Reaction by Polydopamine Derived 3D Interconnected, Iron Carbide Embedded Graphitic Carbon.

Recent advancements on the development of nonprecious electrocatalysts with iron (Fe) incorporated active centers have generated confidence on realizing cost-effective proton exchange membrane fuel cells (PEMFCs). However, most of these catalysts that emerged as a substitution for the platinum supported on carbon (Pt/C) catalysts in oxygen reduction reaction (ORR) are active under basic conditions, and their feasibility in PEMFCs remains as a challenge. In this scenario, this work reports the synthesis of a Pt-free oxygen reduction electrocatalyst prepared by the annealing of polydopamine grown melamine foam.

Long-term survival outcome of advanced epithelial ovarian cancer: A single institutional study.

Background: A number of patients with advanced-stage epithelial ovarian cancer do survive beyond 5 years. The long-term follow-up data are limited, especially for the Indian setting. We evaluated the 10-year survival outcome and influencing clinicopathological factors.

SparkINFERNO: a scalable high-throughput pipeline for inferring molecular mechanisms of non-coding genetic variants.

Summary: We report Spark-based INFERence of the molecular mechanisms of NOn-coding genetic variants (SparkINFERNO), a scalable bioinformatics pipeline characterizing non-coding genome-wide association study (GWAS) association findings. SparkINFERNO prioritizes causal variants underlying GWAS association signals and reports relevant regulatory elements, tissue contexts and plausible target genes they affect. To achieve this, the SparkINFERNO algorithm integrates GWAS summary statistics with large-scale collection of functional genomics datasets spanning enhancer activity, transcription factor binding, expression quantitative trait loci and other functional datasets across more than 400 tissues and cell types.

Development of perceived prenatal maternal stress scale.

Background: Pregnancy is a state, which is often associated with extreme joy and happiness. Women undergo a number of physiological and psychological changes during pregnancy, which are often stressful if aligned with other adverse life events, compromising their health and well-being. However, there exists no comprehensive psychological instruments for measuring this stress.

NiCoO nanoarray on CNT sponge: a bifunctional oxygen electrode material for rechargeable Zn-air batteries.

Ni- and Co-based materials have of late gained prominence over conventional noble metal-based ones as catalysts for energy devices. Here, a high performance catalyst which can facilitate both the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) was developed by anchoring a NiCoO nanowire array on a carbon nanotube sponge (NCS). The three-dimensional morphology of NCS ensured efficient transport of the reactants and products on the catalyst surface, thereby improving the activity of the material.

Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis.

Importance: It is unclear whether female carriers of the apolipoprotein E (APOE) ε4 allele are at greater risk of developing Alzheimer disease (AD) than men, and the sex-dependent association of mild cognitive impairment (MCI) and APOE has not been established.

Objective: To determine how sex and APOE genotype affect the risks for developing MCI and AD.

Data Sources: Twenty-seven independent research studies in the Global Alzheimer's Association Interactive Network with data on nearly 58 000 participants.

Decreased Survival With Mastectomy Vis-à-Vis Breast-Conserving Surgery in Stage II and III Breast Cancers: A Comparative Treatment Effectiveness Study.

Purpose: The primary purpose of hospital-based cancer registries is assessing patient care. Clinical stage-based survival and treatment-based survival are some of the key parameters for such assessment. Because of the challenges in obtaining follow-up parameters, a separate study on patterns of care and survival was undertaken by the Indian National Cancer Registry Program.

High-index faceted Au nanocrystals with highly controllable optical properties and electro-catalytic activity.

We introduce a new and naturally abundant mild reducing agent, tannic acid, to improve the seed-mediated growth method for the synthesis of elongated tetrahexahedral Au nanocrystals enclosed with high-index (730) planes, at room-temperature. The control of the dimensions, plasmonics and electro-catalysis of such high-index faceted nanocrystals is remarkable.

Concurrent Chemoradiation for Cancer of the Cervix: Results of a Multi-Institutional Study From the Setting of a Developing Country (India).

Purpose: The primary output of hospital-based cancer registries is data on cancer stage and treatment-based survival that can be used to evaluate patient care, but because there are many challenges in obtaining follow-up details, a separate study on patterns of care and patterns of survival for patients at selected sites was initiated under the National Cancer Registry Programme of India. This article presents the results for cervical cancer.

Patients And Methods: A standardized patient information form was used to record patient information, and data were entered into a central repository-the National Centre for Disease Informatics and Research.

Liquid crystal polaroid glass electrode from e-waste for synchronized removal/recovery of Cr(+6) from wastewater by microbial fuel cell.

This study demonstrates the use of Liquid Crystal coated Polaroid Glass Electrode (LCPGE) material collected from disposed liquid-crystal display (LCD) computer monitor as electrodes in microbial fuel cell (MFC) for the simultaneous reduction/recovery of Cr(+6) from chromium wastewater. Fourier transform infrared spectrum (FT-IR) confirms the presence of NH2, CN, CO and OC and/or COC functional groups in LCPGE. An excellent electrochemical performance with distinct redox peaks were observed in cyclic voltammetry test (100 mV/s).

Colonic polyposis syndromes--an experience from a tertiary centre in South India.

Background: Several polyposis syndromes of the gastrointestinal tract have been recognized which carry increased risk for cancer and have a genetic predisposition. There is a paucity of literature regarding the occurrence and the burden of colonic polyposis syndromes in the Indian subcontinent. This study attempts to highlight this hitherto unaddressed burden and the associated increased risk for inherited colonic cancer in this geographical location.

Hexavalent chromium reduction and energy recovery by using dual-chambered microbial fuel cell.

Microbial fuel cell (MFC) technology is utilized to treat hexavalent chromium (Cr(VI)) from wastewater and to generate electricity simultaneously. The Cr(VI) is bioelectrochemically reduced to non-toxic Cr(III) form in the presence of an organic electron donor in a dual-chambered MFC. The Cr(VI) as catholyte and artificial wastewater inoculated with anaerobic sludge as anolyte, Cr(VI) at 100 mg/L was completely removed within 48 h (initial pH value 2.

Computational fluid dynamics modeling of laboratory flames and an industrial flare.

A computational fluid dynamics (CFD) methodology for simulating the combustion process has been validated with experimental results. Three different types of experimental setups were used to validate the CFD model. These setups include an industrial-scale flare setups and two lab-scale flames.

Layer-separated distribution of nitrogen doped graphene by wrapping on carbon nitride tetrapods for enhanced oxygen reduction reactions in acidic medium.

Layer-separated 3D nitrogen doped graphene (NG) with an accessible interstitial surface and modulated activity characteristics for oxygen reduction in acidic medium could be prepared by wrapping NG sheets on in situ generated carbon nitride (CNx) tetrapods.