Publications by authors named "Gangadhar Rao Mathi"
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Synopsis of recent research by authors named "Gangadhar Rao Mathi"
- Gangadhar Rao Mathi's research focuses on developing innovative synthetic methods for the functionalization of nitrogen-containing heterocycles, particularly pyridinium and pyrimidine derivatives, through various catalytic and photochemical approaches.
- Significant advancements include the enantioselective functionalization of pyridinium salts using N-heterocyclic carbene (NHC) catalysts, and the regioselective C-H functionalization of heteroarene N-oxides facilitated by traceless nucleophiles, expanding the scope of synthetic methodologies.
- His work also encompasses the discovery and optimization of novel inhibitors for anaplastic lymphoma kinase (ALK), contributing to the field of medicinal chemistry with promising compounds that enhance activity against drug-resistant cancer mutants.
