Five Mesoporous Lanthanide Metal-Organic Frameworks: Syntheses, Structures, and Fluorescence Sensing of Fe, CrO, and HO and Electrochemical Sensing of Trinitrophenol.

When a multicarboxylate aromatic ligand, 3,5-di(2',4'-dicarboxylphenyl)benzoic acid (HL), was employed, five structurally similar lanthanide metal-organic frameworks (Ln-MOFs), {[PrL(OH)Cl(HO)]·4CHN} (), {[NdL(OH) (HO)]·4CHN} (), {[GdL(OH)(HO)]·4CHN} (), {[HoL(OH) (HO)]·4CHN} () and {[ErL(OH)(HO)]·4CHN} (), were synthesized and characterized. Single-crystal X-ray structural analyses disclosed that all five Ln-MOFs crystallize in the trigonal space group. They have three-dimensional mesoporous structure featuring the coexistence of binuclear and tetranuclear species as inorganic building units.

Novel Multifunctional Samarium-Organic Framework for Fluorescence Sensing of Ag, MnO , and Cimetidine and Electrochemical Sensing of -Nitrophenol in Aqueous Solutions.

A novel Sm-metal-organic framework (MOF) sensor with the molecular formula Sm(HDBA)·HO has been prepared based on a penta-carboxyl organic ligand (HDBA = 3,5-di(2',4'-dicarboxylphenyl)benzoic acid) and samarium nitrate under solvothermal conditions. Sm-MOF is characterized by single-crystal X-ray diffraction analysis, elemental analysis, thermogravimetric analysis, and powder X-ray diffraction analysis. Structural analysis shows that the dimer metal units are alternately connected to form a one-dimensional chain, and this chain is connected by the bridging carboxyl oxygen of the ligand HDBA to form a two-dimensional double-layer plane, which then expands into a three-dimensional microporous framework.

A Multifunctional Tb-MOF Detector for HO, Fe, CrO , and TPA Explosive Featuring Coexistence of Binuclear and Tetranuclear Clusters.

A novel three-dimensional microporous terbium(III) metal-organic framework (Tb-MOF) named as [Tb (DBA)(OH)(HO)]·(HO) (), was successfully obtained by a solvothermal method based on terbium nitrate and 5-di(2',4'-dicarboxylphenyl) benzoic acid (HDBA). The Tb-MOF has been characterized by single crystal X-ray diffraction, elemental analysis, thermogravimetry, and fluorescence properties, and the purity was further confirmed by powder X-ray diffraction (PXRD) analysis. Structural analysis shows that there are two kinds of metal cluster species: binuclear and tetranuclear, which are linked by HDBA ligands in two μ high coordination fashions into a three-dimensional microporous framework.

Gan-Dan-Liang-Yi-Tang alleviates p-chlorophenylalanine-induced insomnia through modification of the serotonergic and immune system.

Gan-Dan-Liang-Yi-Tang (GDLYT) is a Traditional Chinese Medicine that has been historically used for the treatment of insomnia. However, investigations into its pharmacological ingredients and the mechanism underlying its sedative and hypnotic effects remain limited. The present study reported the detailed mechanisms underlying the sedative and hypnotic effects of GDLYT.

A representative prescription for emotional disease, Ding-Zhi-Xiao-Wan restores 5-HT system deficit through interfering the synthesis and transshipment in chronic mild stress-induced depressive rats.

Ethnopharmacological Relevance: Ding-Zhi-Xiao-Wan (DZ, also known as Kai-Xin-San) is a famous traditional Chinese medicine used for the treatment of emotional disease. Previously, we have found that in a variety of animal models of depression (such as tail suspension model, model of chronic fatigue and forced swimming model) DZ demonstrated significant antidepressant behavior and promoted the production of 5-hydroxytryptamine (5-HT). However, the mechanisms of 5-HT regulation are still unclear.

Effect of kai xin san on learning and memory in a rat model of paradoxical sleep deprivation.

The present study aimed to evaluate the effect of kai xin san (KXS, at doses of 500, 250, and 125 mg/kg body weight per day), a well-known traditional Chinese medicine, on learning and memory in paradoxical sleep deprivation (PSD)-induced cognition deficit rats. Two behavior tests (the Open Field test and the Morris water maze task) were used for testing the effects of KXS on a PSD-induced learning and memory deficit model. Furthermore, its effect on the glutamic acid (GLU) and γ-amino-butyric acid (GABA) levels in the brain tissue, brain-derived neurotrophic factor (BDNF), cyclic AMP response element binding protein (CREB), and phosphorylated-CREB (p-CREB) expression in the hippocampus was also tested.

[Effect and mechanism of dingzhixiao wan on scopolamine-induced learning-memory impairment in mice].

Objective: To investigate the effect of Dingzhixiao Wan (DZXW), a classic traditional Chinese medicine formula consisting of Acorus tatarinowii, Polygala tenuifolia, Poria cocos and Panax ginseng in a proportion of 2: 2: 3: 3, on learning-memory impairment induced by scopolamine and its possible mechanisms.

Method: The mice were randomly divided into six groups: the control group, the model group, the positive huperzine A (0.05 mg x kg(-1)) group, DZXW 700 mg x kg(-1), 350 mg x kg(-1) and 175 mg kg(-1) groups.