Publications by authors named "Gang-Can Li"
[Mechanisms of sorafenib induced NB4 cell apoptosis].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2015
Objective: To investigate the effects of sorafenib on human acute promyelocytic leukemia cell NB4 and its mechanism.
Methods: The human acute promyelocytic leukemia cell NB4 was treated with different concentrations (0, 1.5, 3, 6 and 12 µmol/L) of sorafenib, the proliferation inhibitory rate of NB4 cells was assayed by MTT, the apoptosis of NB4 was determined with flow-cytomatry after treatment; after extraction of total protein, the Western blot was performed to determine the expressions of apoptosis-relatived molecules Caspase-3, Caspase-8 and MCL-1.