Publications by authors named "Gang Zhu"

Introduction: Gut microbiota plays an important role in tic disorders (TDs); however, clinical research on probiotics for chronic TDs treatment is lacking. We aimed to investigate the effectiveness of probiotics, hypothesizing that their clinical efficacy is comparable to that of clonidine in treating chronic TDs.

Methods: Patients were randomly assigned to receive either Limosilactobacillus reuteri or clonidine transdermal patch treatment for 8 weeks while maintaining their existing treatment.

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  • Displaced fragility fractures of the pelvis (FFP) present major challenges in orthopedic trauma, especially in older patients with weak bones and other health issues, but no robotic solutions have been documented for managing these fractures.
  • A study evaluated a new robot-assisted fracture reduction system on 15 elderly patients, achieving a 100% success rate in fracture reduction and excellent recovery scores after 6 months.
  • The innovative system enhances surgical precision and effectiveness, potentially transforming the treatment of FFP in an aging population by addressing the complexities associated with traditional methods.
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  • The study investigates the role of circular RNA circTMCO3 in sepsis-induced acute kidney injury (S-AKI), finding that circTMCO3 expression is reduced in S-AKI models, which negatively impacts kidney health.* -
  • Introducing circTMCO3 into cell models enhances kidney cell survival and reduces injury by counteracting inflammation and oxidative stress, while its downregulation worsens these conditions.* -
  • The protective mechanism of circTMCO3 involves its interaction with miR-218-5p and ZEB2, suggesting that boosting circTMCO3 levels may provide a new therapeutic approach for treating S-AKI.*
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  • Individuals with major depressive disorder (MDD) show cognitive impairment and childhood trauma (CT) may increase the risk of MDD and cognitive dysfunction, although its specific impact on MDD patients and healthy controls (HCs) was not fully understood.
  • In a study involving 909 participants, the relationship between MDD, CT, and cognitive function was assessed using tests, and it was found that the effects of CT on cognitive performance disappeared when accounting for MDD diagnosis and education level.
  • After treatment with selective serotonin reuptake inhibitors (SSRIs), CT did not significantly affect changes in cognitive function or depressive symptoms, suggesting the influence of CT on cognitive function in MDD patients may be over-stated.
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Background: Autism spectrum disorder (ASD) has been associated with disrupted brain connectivity, yet a comprehensive understanding of the dynamic neural underpinnings remains lacking. This study employed concurrent electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) techniques to investigate dynamic functional connectivity (dFC) patterns and neurovascular characteristics in children with ASD. We also explored associations between neurovascular characteristics and the developmental trajectory of adaptive behavior in individuals with ASD.

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Oxidative stress (OS) is strongly implicated in the pathophysiology of major depressive disorder (MDD) but the molecular mechanisms remain largely unknown. The purpose of this study is to identify genes related to both OS and MDD, and further to evaluate the utility of these genes as diagnostic markers and potential treatment targets. We searched datasets related to MDD from the Gene Expression Omnibus (GEO) database for differentially expressed genes (DEGs) also related to OS according to GeneCards.

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  • The TAND Checklist is a valuable tool to screen for neuropsychiatric disorders associated with tuberous sclerosis complex (TSC).
  • It consists of six dimensions and 12 sections, making it a detailed assessment framework.
  • When used with Chinese individuals who have TSC, the checklist helps evaluate a wide range of potential symptoms effectively.
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HNRNPA2B1 is a member of the HNRNP family, which is associated with telomere function, mRNA translation, and splicing, and plays an important role in tumor development. To date, there have been no pan-cancer studies of HNRNPA2B1, particularly within the TME. Therefore, we conducted a pan-cancer analysis of HNRNPA2B1 using TCGA data.

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A novel photoelectrochemical (PEC) biosensor was developed incorporating a specifically designed RNA aptamer for the detection of theophylline (TP). This involved utilizing two nucleotide base aptamers with tailored sequences designed to target TP. The 3' end of a single-stranded RNA sequence (5'-GGAUACCA-(CH)-SH-3') and the 5' end of a complementary stranded RNA sequence (5'-HS-(CH)-CCUUGGAAGCC-3') were linked to gold nanoparticles (AuNPs) and CdS quantum dots (QDs), respectively.

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Flavin monooxygenases (FMOs) have been widely used in the biosynthesis of natural compounds due to their excellent stereoselectivity, regioselectivity and chemoselectivity. Stenotrophomonas maltophilia flavin monooxygenase (SmFMO) has been reported to catalyze the oxidation of various thiols to corresponding sulfoxides, but its activity is relatively low. Herein, we obtained a mutant SmFMO which showed 4.

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Objective: To correlate the utility of the Fundamentals of Laparoscopic Surgery (FLS) manual skills program with the Objective Structured Assessment of Technical Skills (OSATS) global rating scale in evaluating operative performance.

Methods: The Asian Urological Surgery Training and Educational Group (AUSTEG) Laparoscopic Upper Tract Surgery Course implemented and validated the FLS program for its usage in laparoscopic surgical training. Delegates' basic laparoscopic skills were assessed using three different training models (peg transfer, precision cutting, and intra-corporeal suturing).

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To improve the heat extraction efficiency from the wellbore fluids to the stratum in the geothermal well, thermal insulation cement, which contains of waste glass powder as a heat-insulating material, is proposed to apply in geothermal well's middle and upper sections in the paper. Effect of such glass powers on mechanic and thermal property of thermal insulation cement was then investigated. Various tests were carried out to measure compressive strength, thermal conductivity, microstructure porosity etc.

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  • The study aimed to assess the safety and effectiveness of using LEO stents in dual stent-assisted embolization (DSAE) for treating wide-necked intracranial bifurcation aneurysms, along with the impact of tirofiban infusion on reducing complications.
  • Clinical data from 562 patients treated at a hospital were analyzed, focusing on a subset of 65 patients who underwent DSAE with LEO stents, noting success rates, complications, and patient outcomes.
  • Results showed a high success rate with minimal complications, as most patients had favorable immediate and follow-up outcomes, demonstrating that the use of LEO stents is a promising option for this condition.
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Purpose: Irreversible electroporation (IRE) is a promising alternative treatment for low-intermediate-risk localized prostate cancer. In this systematic review we aim to evaluate the safety profile and functional and oncological outcomes of this new technique.

Materials And Methods: A systematic review of the literature was performed on PubMed, EMBASE, and Scopus up to 24 August 2023.

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Background: Whether there is a sex difference in the outcome of aneurysmal subarachnoid hemorrhage (aSAH) remains controversial, and clarifying the role of women in postoperative cerebral ischemic events can help us to understand its relationship with poor prognosis. Therefore, the purpose of this study was to elucidate the relationship between the three aspects of sex differences, postoperative cerebral ischemia, and poor prognosis after aSAH.

Methods: A total of 472 patients admitted within 72 h after aSAH between January 2018 and December 2022 were included.

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  • - The study conducted a meta-analysis to assess the safety and effectiveness of Atezolizumab plus Bevacizumab (Atez/Bev) compared to Lenvatinib (LEN) as first-line treatments for unresectable hepatocellular carcinoma (u-HCC), utilizing data from multiple clinical studies involving nearly 5,000 patients.
  • - Results indicated that Atez/Bev significantly improved progression-free survival (PFS) and reduced adverse events compared to LEN, although there was no difference in overall survival (OS) or treatment response rates between the two therapies.
  • - Subgroup analyses revealed that Atez/Bev benefited patients with viral hepatitis by enhancing OS, while LEN was more effective in improving
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Aims: The extent of perihematomal edema following intracerebral hemorrhage (ICH) significantly impacts patient prognosis, and disruption of the blood-brain barrier (BBB) exacerbates perihematomal edema. However, the role of peripheral IL-10 in mitigating BBB disruption through pathways that link peripheral and central nervous system signals remains poorly understood.

Methods: Recombinant IL-10 was administered to ICH model mice via caudal vein injection, an IL-10-inhibiting adeno-associated virus and an IL-10 receptor knockout plasmid were delivered intraventricularly, and neurobehavioral deficits, perihematomal edema, BBB disruption, and the expression of JAK1 and STAT3 were evaluated.

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Objective: Employing whole-exome sequencing (WES) technology to investigate the etiology of infantile epileptic spasm syndrome (IESS), and determining whether different etiologies exhibit phenotypic variations, while elucidating the potential associated factors, might improve short-term responses to first-line treatment.

Methods: We retrospectively evaluated patients with IESS admitted for treatment between January 2018 and June 2023. Clinical phenotypic differences among etiological classifications and clinical manifestations were analyzed.

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Background: Several biallelic truncating and missense variants of the gem nuclear organelle-associated protein 5 (GEMIN5) gene have been reported to cause neurodevelopmental disorders characterized by cerebellar atrophy, intellectual disability, and motor dysfunction. However, the association between biallelic GEMIN5 variants and early-infantile developmental and epileptic encephalopathies (EIDEEs) has not been reported.

Purpose: This study aimed to expand the phenotypic spectrum of GEMIN5 and explore the correlations between epilepsy and molecular sub-regional locations.

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Objective: Gliomas are associated with high rates of disability and mortality, and currently, there is a lack of specific and sensitive biomarkers for diagnosis. The ideal biomarkers should be detected early through noninvasive methods. Our research aims to develop a rapid, convenient, noninvasive diagnostic method for gliomas, as well as for grading and differentiation.

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Steel slag and waste clay bricks are two prevalent solid waste materials generated during industrial production. The complex chemical compositions of these materials present challenges to their utilization in conventional alumina silicate ceramics manufacturing. A new type of ceramic tile, which utilizes steel slag and waste clay brick as raw materials, has been successfully developed in order to effectively utilize these solid wastes.

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In response to the escalating concerns over antibiotics in aquatic environments, the photo-Fenton reaction has been spotlighted as a promising approach to address this issue. Herein, a novel heterogeneous photo-Fenton catalyst (FeO/WPC) with magnetic recyclability was synthesized through a facile two-step process that included in situ growth and subsequent carbonization treatment. This catalyst was utilized to expedite the photocatalytic decomposition of ciprofloxacin (CIP) assisted by HO.

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Background: Major perioperative complications of stent-assisted embolization treated for aneurysmal subarachnoid hemorrhage patients include the formation of thromboembolic events (TEs) and hemorrhagic events (HEs), for which antiplatelet protocols play a key role.

Methods: We conducted a single-center retrospective analysis to compare the differences between arteriovenous tirofiban administration with traditional oral dual antiplatelet therapy (DAPT). A total of 417 consecutive patients were enrolled.

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