Publications by authors named "Gang Xie"
Insulin like growth factor binding protein 7 activate JNK/ERK signaling to aggravate uranium-induced renal cell cytotoxicity.
Naunyn Schmiedebergs Arch Pharmacol
March 2025
Acute kidney injury (AKI) can occur primarily by exposing kidneys to uranium (U). Insulin-like growth factor binding protein 7 (IGFBP7) can regulate sepsis-induced AKI and epithelial-mesenchymal transition through ERK1/2 signaling. In vitro, the IGFBP7's role and mechanism of action in uranium-induced NRK-52E cells, however, remains unknown.
View Article and Find Full Text PDFThe development of a high-performance gas sensor for the rapid and efficient detection of harmful SF decomposition gases (HS, SO, and SOF) is crucial for equipment environmental monitoring and safeguarding human health. In this work, first-principles calculations were conducted to assess the adsorption performance and sensing characteristics of these decomposition gases on two-dimensional metal-dimer-modified phthalocyanine (MnPc, TcPc, and MnTcPc) surfaces. The results demonstrate that the MnPc, TcPc, and MnTcPc monolayers possess enhanced structural stability.
View Article and Find Full Text PDFSalvia miltiorrhiza Bunge is an ornamental plant known for its diverse flower colors, ranging from white to dark violet. To elucidate the regulatory mechanisms underlying flower color, we conducted QTL mapping and identified candidate genes involved in anthocyanidin accumulation. Total anthocyanidin content and six anthocyanidins in the corollas of S.
View Article and Find Full Text PDFExploring the changes in plant functional traits and their relationship with the environment in karst climax communities across different latitudes can enhance our understanding of how these communities respond to environmental gradients. In this study, we focus on climax karst climax plant communities in Guizhou Province, China. We selected three sample sites located at varying latitudes and analyzed the variations in functional traits of the plant communities at these latitudes.
View Article and Find Full Text PDFThe coastal wetland of the Yellow River Estuary, one of China's largest wetlands, is essential for biodiversity conservation and ecosystem services. Ecological water replenishment, a typical wetland restoration measure in the Yellow River Delta, has significantly impacted the habitat of zoobenthos, which are critical indicators of ecosystem health and water quality. However, the community characteristics of zoobenthos in this coastal wetland are poorly understood.
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- Researchers developed a machine learning model using unenhanced CT scans to evaluate the risk of malignant cerebral edema (MCE) in patients with acute ischemic stroke (AIS).
- The study involved 179 patients assigned to training and validation groups, analyzing radiomics features related to MCE through various statistical methods and constructing predictive models.
- Logistic regression was identified as the most effective algorithm, with high accuracy rates in predicting MCE, suggesting the model can aid in clinical decision-making and patient prognosis.
The clinical spectrum and pathogenesis associated with KMT2B variants in Chinese pediatric patients.
Parkinsonism Relat Disord
December 2024
Article Synopsis
- The study aimed to evaluate the clinical features and underlying causes of KMT2B variants in Chinese children with dystonia or developmental delay, analyzing data from 27 patients.
- A significant majority (26 patients) had various forms of dystonia, often worsened by factors like fever, and some also experienced additional movement disorders and developmental delays.
- The research found 26 unique pathogenic KMT2B variants, with many linked to mitochondrial dysfunction, impacting cellular respiration and mitochondrial structure in patient fibroblasts.
Article Synopsis
- * SMEB, created through free radical polymerization, was extensively analyzed and showed a particle size ranging from 60.68 to 157.39 nm, and a decomposition temperature of 334 °C, suitable for high-temperature shale applications.
- * The incorporation of 0.5 wt % SMEB into oil-based drilling fluids demonstrated high sealing efficiency (up to 86.70%) without negatively impacting the fluids' rheological properties, suggesting its potential as an effective sealing agent.
Article Synopsis
- * A new superhydrophilic carbon aerogel (CA) was created using a hydrothermal process with carbohydrates and polymers, which displayed a unique porous structure and high specific surface area.
- * The CA suspension significantly improved root growth in wheat seedlings, resulting in longer and thicker roots due to increased cell division and hormonal gene expression.
A novel, efficient, and practical route to dibenzoxazepinones has been developed through a one-pot heterogeneous palladium-catalyzed aminocarbonylation/aromatic nucleophilic substitution (SAr) sequence starting from readily available 2-iodofluorobenzenes and 2-aminophenols. The carbonylative cyclization reaction proceeds smoothly in dimethyl sulfoxide (DMSO) at 120 °C with 1,8-diazabicyclo(5.4.
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- Researchers developed machine learning models using non-contrast computed tomography images and clinical data to assess the risk of hemorrhagic transformation (HT) in patients with acute ischemic stroke (AIS).
- A study involving 180 AIS patients revealed that 104 experienced HT, with significant clinical differences in factors like the neutrophil-to-lymphocyte ratio and infarct volume between those who did and did not have HT.
- The optimal ML model for predicting HT was logistic regression, achieving high predictive accuracy, particularly with a combined clinical-radiomics approach, which showed an area under the curve (AUC) of 0.957 in validation.
Article Synopsis
- Solitary fibrous tumors (SFT) are rare fibroblastic neoplasms, with an unusual occurrence in the pineal gland, as highlighted in a case study of a 58-year-old male.
- The patient presented symptoms like recurrent hiccups, acid reflux, and headaches, and imaging revealed a tumor in the pineal region that was surgically removed.
- Pathological analysis confirmed it as a grade 1 SFT, and post-surgery treatment included radiotherapy, leading to no signs of recurrence during long-term follow-up.
Article Synopsis
- Online travel agency (OTA) platforms often engage in unfair practices that harm both consumers and airlines, prompting a need for better governance and oversight in the ticket sales market.
- A game model is developed to examine how airlines, platforms, and consumers can collaborate to address these issues and improve cooperative supervision.
- The study suggests that stricter airline control over ticket sales, higher fines for misconduct, and better consumer rights protection can enhance cooperation and accountability among all parties, advocating for a market-based solution to encourage self-regulation.
Article Synopsis
- - Osteoporosis is a serious condition causing weakened bones and increased fracture risk, particularly in older individuals, highlighting the need for better treatment options with fewer side effects.
- - Trifolirhizin, a natural compound from Sophora flavescens, was studied for its effects on osteoclast formation and function, showing potential in reducing bone resorption and protecting against bone loss in mice.
- - The research found that trifolirhizin inhibits key signaling pathways related to bone loss, suggesting it could be a promising therapeutic agent for osteoporosis and related diseases.
Article Synopsis
- Organic-inorganic hybrid metal halide perovskite solar cells are seen as a promising future technology, but issues like defects and Li ionic migration hinder their efficiency and stability.
- Researchers developed two crown ether derivatives, PC12 and PC15, that can selectively bind to different metal cations and help improve the manufacturing process and performance of these solar cells.
- Using these compounds together enhances the solar cell's efficiency to 24.8% and significantly boosts its stability against humidity, heat, and light exposure.
Lithium metal anode has attracted wide attention due to its ultrahigh theoretical specific capacity, lowest reduction potential, and low density. However, uncontrollable dendritic growth and volume change caused by uneven Li deposition still seriously hinder the large-scale commercial application of lithium metal batteries, even causing serious battery explosions and other safety problems. Hence, gold nanoparticles with a gradient distribution anchored on 3D carbon fiber paper (CP) current collectors followed by the encapsulation of polydopamine (PDA) (CP/Au/PDA) are constructed for stable and dendrite-free Li metal anodes for the first time.
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- The Lady Tasting Tea experiment tests if a person can distinguish between two methods of making tea: adding milk first or brewing tea first.
- A Bayesian Network (BN) is proposed to analyze the results of this experiment, focusing on how well the participant (the Lady) can identify the preparation method.
- The BN model allows for the calculation of posterior probabilities based on the Lady's prior confidence levels (ranging from guessing to being certain), helping to infer her judgment accuracy.
Article Synopsis
- The evolution of SARS-CoV-2 variants highlights the need for multivalent vaccines, leading to the development of SCTV01E, a tetravalent COVID-19 vaccine targeting variants Alpha, Beta, Delta, and Omicron BA.1.
- A double-blind placebo-controlled trial showed SCTV01E had a vaccine efficacy of 69.4% against COVID-19 seven days post-vaccination, with higher efficacy rates in preventing symptomatic and all infections at 14 days.
- The vaccine demonstrated a significant neutralizing antibody response against Omicron BA.5 and had mild reactogenicity, indicating its potential effectiveness against emerging SARS-CoV-2 variants.
Article Synopsis
- Nuclear protein testis (NUT) carcinoma is a rare and aggressive tumor linked to chromosomal rearrangements of the NUTM1 gene, mainly affecting areas like the head, neck, and lungs, and is rarely found in the oral cavity.
- A study involved analyzing 111 tumor samples from different hospitals using immunohistochemistry (IHC), fluorescence in-situ hybridization (FISH), and RNA sequencing to detect NUT protein expression and genetic rearrangements.
- The study identified NUT protein expression in 5 cases (4.5%) located in various oral areas, with genetic analyses revealing distinct rearrangement patterns, underscoring the need for accurate detection of NUT carcinoma to prevent misdiagnoses, particularly
The fabrication of the flexible devices with excellent photovoltaic performance and stability is critical for the commercialization of organic solar cells (OSCs). Herein, the conjugated dimer acceptor DY-TVCl and the non-conjugated dimer acceptor DY-3T based on the monomer MY-BO are synthesized to regulate the molecular glass transition temperatures (T) for improving the morphology stability of active layer films. And the crack onset strain values for the blend films based on dimer acceptors are superior than that of small molecule, which are beneficial for the preparation of flexible devices.
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- Accurate and rapid histopathological diagnosis is crucial for breast cancer, and traditional methods can be slow when analyzing large tissue sections.
- The study introduces a dual-modal Raman imaging technique that combines Raman mapping and bright-field microscopy to create virtual stained images of breast cancer tissues.
- This new method can distinguish different tissue types effectively and improves imaging speed by up to 65 times compared to standard Raman methods, making it a promising tool for clinical use.
Article Synopsis
- An observational study evaluated a clinical simulation experience aimed at enhancing interprofessional competencies among healthcare professional students in NSW, Australia, involving over 200 participants.
- 189 students, primarily from occupational therapy, physiotherapy, and speech pathology programs, participated, assessing their skills through the revised Interprofessional Collaborative Attainment Survey (ICCAS).
- Results showed a significant improvement in self-assessed interprofessional collaborative competencies, suggesting that structured simulation experiences can effectively prepare students for rural healthcare practices.
As one of the main components of solid propellant, ammonium perchlorate (AP) shows slow sluggish decomposition kinetics with unconcentrated heat release. To achieve efficient catalytical decomposition, it is a significant challenge to design reasonable catalyst structure and explore the interaction between catalyst and AP. Herein, a series of porous carbon supported spinel-typed homogeneous heterometallic composites CuCoO/C via pyrolysis of MOF-74-Co doped Cu.
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- Odorant-binding proteins (OBPs) are essential for insect smell, with DcitOBP9 being a key OBP in citrus psyllids, consisting of 148 amino acids and classified under the Classical-OBP family.
- DcitOBP9 is expressed consistently throughout the life stages of the citrus psyllid, with the highest levels found in adult antennae, and shows strong binding affinity to various odorants like ocimene and linalool.
- Molecular simulations point to specific amino acid residues crucial for odorant interaction, indicating that DcitOBP9 plays a significant role in the insect's ability to recognize and select host plants, potentially aiding in the development of pest control strategies.
Article Synopsis
- The study aimed to develop a machine learning model that uses dual-energy CT enterography (DECTE) to noninvasively assess Crohn's disease (CD) activity, which is typically evaluated through an invasive scoring method called SES-CD.
- A total of 202 bowel segments from 46 CD patients were analyzed, and the models showed an area under the ROC curve (AUC) between 0.81 and 0.87 for accurately assessing CD activity based on DECTE parameters.
- The results suggest that the machine learning model effectively and quantitatively evaluates CD activity, making it a promising alternative to traditional invasive methods.