Self-healing, deformable and safe integrated supercapacitor enabled by synergistic effect of multiple physical interactions in gel polymer electrolyte with dual-role Co.

With the rapid development of wearable electronic devices, flexible supercapacitors have gained strong interest. However, traditional sandwich supercapacitors have weak interfacial binding, resulting in high interface resistance and poor deformability. Herein, a self-healing integrated supercapacitor based on a polyacrylic acid-polyisodecyl methacrylate-CoSO gel polymer electrolyte (GPE) was developed.

Ligand-binding assays validated for quantitative bioanalysis of a novel antibody-drug conjugate in monkey serum and related application in a nonclinical study.

Background: Antibody-drug conjugates (ADCs) are an emerging class of targeted therapeutics and are receiving growing attention in the pharmaceutical field. Here we aimed to validate two ligand binding assays for the quantitation of GQ1001, an ADC made of Trastuzumab site-specifically conjugated with DM1, in cynomolgus monkey serum, and then apply the validated assays to a nonclinical study.

Methods: The quantitative methods for conjugated GQ1001 and total GQ1001 were validated against regulatory guidance documents on bioanalytical method validation under a Good Laboratory Practice (GLP)-compliant environment.

Application of pedicled supraclavicular flaps in hypopharyngectomy with preservation of laryngeal function.

Objective: To evaluate the efficacy of pedicled supraclavicular flaps in hypopharyngectomy reconstruction, with a focus on preserving laryngeal function.

Methods: From August 2019 to June 2022, 14 patients with primary hypopharyngeal carcinoma who met the inclusion and exclusion criteria and underwent the repair of hypopharyngeal defects using pedicled supraclavicular flaps were included retrospectively. Relevant clinical evaluation indicators include patient characteristics, defect sizes, flap sizes, flap harvesting time, postoperative hospital stay, postoperative complications, recurrence, and survival outcomes.

Economic evaluation of short message service intervention for HIV prevention among men who have sex with men in China: a modelling study.

Background: Men who have sex with men (MSM) globally face a high risk of HIV infection. Previous studies indicate that customized short message service (SMS) interventions could reduce high-risk behaviors that associated with HIV transmission. This study aims to evaluate the health and economic impacts of such interventions among MSM in China.

Revolutionizing head and neck squamous cell carcinoma treatment with nanomedicine in the era of immunotherapy.

Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignant tumor globally. Despite advancements in treatment methods, the overall survival rate remains low due to limitations such as poor targeting and low bioavailability, which result in the limited efficacy of traditional drug therapies. Nanomedicine is considered to be a promising strategy in tumor therapy, offering the potential for maximal anti-tumor effects.

Clinical application value of simultaneous plasma and bronchoalveolar lavage fluid metagenomic next generation sequencing in patients with pneumonia-derived sepsis.

Background: Despite the increasing use of metagenomic next-generation sequencing (mNGS) in sepsis, identifying clinically relevant pathogens remains challenging. This study was aimed to evaluate the clinical utility of simultaneous plasma and bronchoalveolar lavage fluid (BALF) detection using mNGS.

Methods: This retrospective study enrolled 95 patients with pneumonia-derived sepsis (PDS) admitted to the intensive care unit (ICU) between October 2021 and January 2023.

Health and Economic Impacts of Introducing Vaccae and Enhanced Drug-Resistant Tuberculosis Management Strategies in China.

Background: China faces the highest burden of latent multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB). We aim to evaluate the health and economic impacts of Vaccae (a novel TB vaccine) and enhanced drug-resistant TB (DR-TB) management strategies.

Methods: Using a compartmental model calibrated with national TB data, we evaluated nine interventions from 2025-2050: enhanced DR-TB management (S1); Vaccae vaccination for those with Mycobacterium tuberculosis infection targeting specific age groups (S2: adolescents, S3: adolescents and young adults, S4: working-age adults, S5: elderly); and combined strategies (S6: S2+S1, S7: S3+S1, S8: S4+S1, S9: S5+S1).

Multifunctional aramid-based composite quasi-solid-state electrolytes for flexible structure batteries.

The integration of flexible structure batteries (FSBs) into electronic equipment is an effective method to significantly improve energy efficiency, whereas traditional battery separators, with poor mechanical properties, low liquid electrolyte capture ability, and weak thermal stability, cannot meet the practical requirements of various applications. To address these challenges, in this study, a multifunctional composite quasi-solid-state electrolyte (CQE) was synthesized by electrospinning poly(vinylidene fluoride-hexafluoropropylene) (PVDF-HFP) fibers on both sides of an aramid nanofibers (ANFs) fibrous film for application in high-performance FSBs. Here, the ANF film serves as a structural framework, thus enhancing the mechanical properties and thermal stability of the CQE, while the "thermal closed-hole effect" and liquid electrolyte capture capability of the PVDF-HFP film in the CQE improve the overall safety of the FSBs.

Modeling the epidemiologic impact of age-targeted vaccination for drug-resistant tuberculosis.

This study used a calibrated mathematical model to evaluate age-specific tuberculosis (TB) vaccination strategies, for drug-resistant (DR)-TB management in China. Prioritizing elderly vaccination significantly reduced multidrug-resistant or rifampicin-resistant TB incidence and mortality, while avoiding the need for second-line treatment, offering a promising approach to mitigate DR-TB burden by 2050.

The Mechanism by Which Ameliorates Osteoarthritis: A Work Based on Network Pharmacology.

Background: (CR) is widely used in traditional Chinese medicine to prevent and treat a variety of diseases. However, its functions and mechanism of action in osteoarthritis (OA) has not been elucidated. Here, a comprehensive strategy combining network pharmacology, molecular docking, molecular dynamics simulation and in vitro experiments was used to address this issue.

Interpregnancy interval, air pollution, and the risk of low birth weight: a retrospective study in China.

Background: Both interpregnancy intervals (IPI) and environmental factors might contribute to low birth weight (LBW). However, the extent to which air pollution influences the effect of IPIs on LBW remains unclear. We aimed to investigate whether IPI and air pollution jointly affect LBW.

Gut microbiota, allergic rhinitis, vasomotor rhinitis, Mendelian randomization, causal association.

Objective: Continuous research on the structure and function of intestinal microecology has confirmed the association between gut microbiota and the occurrence, development, and outcome of allergic diseases. Here, we explored the genetic causality between gut microbiota and rhinitis.

Methods: We conducted a two-sample Mendelian Randomization (MR) study to investigate the genetic causal relationship between gut microbiota and allergic rhinitis and vasomotor rhinitis.

Nomogram for Predicting the Risk of Short Sleep Duration in Myocardial Infarction Survivors.

Background: Research on post-infarction insomnia, particularly short sleep duration following myocardial infarction (MI), remains limited. Currently, there are no existing guidelines or risk prediction models to assist physicians in managing or preventing short sleep duration or insomnia following MI. This study aims to develop a nomogram for predicting the risk of short sleep duration after MI.

Bibliometric analysis of T cells in allergic rhinitis.

Unlabelled: By reviewing the relevant literature in the field of T cell and allergic rhinitis, we determined the development status, study hotspots, and research frontiers viewpoints of this field to provide a reference for researchers and clinical workers.

Methods: Web of Science Core Collection (WoSCC) was applied to obtain the studies related to T cells and allergic rhinitis (AR) from 2003 to 2023, and the information extracted from these studies was analyzed using CiteSpace 6.1.

A Novel Nano-Laminated GdBC with Excellent Electromagnetic Wave Absorption Performance and Ultra-High-Temperature Thermostability.

A novel nano-laminated GdBC material was successfully synthesized using GdH, BC, and C an in situ solid-state reaction approach for the first time. The formation process of GdBC was revealed based on the microstructure and phase evolution investigation. Purity of 96.

Integration of molecular breeding and multi-resistance screening for developing a promising restorer line Guihui5501 with heavy grain, good grain quality, and endurance to biotic and abiotic stresses.

Rice, a critical staple on a global scale, faces escalating challenges in yield preservation due to the rising prevalence of abiotic and biotic stressors, exacerbated by frequent climatic fluctuations in recent years. Moreover, the scorching climate prevalent in the rice-growing regions of South China poses obstacles to the cultivation of good-quality, heavy-grain varieties. Addressing this dilemma requires the development of resilient varieties capable of withstanding multiple stress factors.

Extreme condition-tolerant stretchable flexible supercapacitor and triboelectric nanogenerator based on carrageenan-enhanced gel for energy storage, energy collection and self-powered sensing.

As flexible electronics devices for energy storage, mechanical energy collection and self-powered sensing, stretchable flexible supercapacitor and triboelectric nanogenerator (TENG) have attracted extensive attention. However, it is difficult to satisfy the requirements of high safety and resistance to extreme conditions. Dual roles of mechanical and electrical enhancement of inorganic salt are put forward, and a carrageenan (CG) enhanced poly (N-hydroxyethyl acrylamide)/CG/lithium chloride/glycerol (PCLG) conductive gel is prepared by designing hydrogen bonding self-crosslinking and chain entanglement.

Quantitative assessment and correlational analysis of subjective and objective indicators in patients with allergic rhinitis.

Background: The diagnosis of allergic rhinitis is mainly based on the typical medical history, clinical manifestations, and corresponding allergen test results of the patients. However, there are often clinical inconsistencies among the 3.

Objective: To study the clinical characteristics of patients with allergic rhinitis from both subjective and objective aspects to determine the correlations between the quantitative assessment outcomes of subjective and objective indicators.

Survival and disease burden analyses of occupational pneumoconiosis during 1958-2021 in Huangshi city, China: a retrospective cohort study.

Background: Pneumoconiosis, a chronic disease stemming from prolonged inhalation of dust particles, stands as a significant global burden of occupational diseases. This study aims to investigate the survival outcomes of pneumoconiosis patients in Huangshi city, China, while also evaluating the disease burden on afflicted patients.

Methods: Data for this study were sourced from the Huangshi Center for Disease Control and Prevention.

Immunomodulation in allergic rhinitis: Insights from Th2 cells and NLRP3/IL-18 pathway.

Allergic rhinitis (AR) is characterized by nasal symptoms such as rubbing and sneezing, often triggered by allergen exposure. The purpose of this study is to dissect the roles of NLRP3-mediated immune modulation and macrophage pyroptosis in modulating T cell differentiation within the context of ovalbumin (OVA)-induced AR in mice. OVA-induced AR was established in mice, evaluating nasal symptoms, macrophage infiltration, cytokine levels, and T cell differentiation.

EGFR and ERBB2 Exon 20 Insertion Mutations in Chinese Non-small Cell Lung Cancer Patients: Pathological and Molecular Characterization, and First-Line Systemic Treatment Evaluation.

Background: Data from studies looking at both EGFR and ERBB2 exon 20 insertion mutations (-20ins) in the same cohort of patients with non-small cell lung cancer (NSCLC) are limited.

Objective: The purpose of this study was to analyze EGFR/ERBB2-20ins in all-stage NSCLC patients to reveal their histological and molecular features, and to retrospectively evaluate the results of first-line real-world systemic treatments in patients with advanced-stage disease.

Patients And Methods: We collected 13,920 formalin-fixed paraffin-embedded NSCLC specimens.