When creating a Schottky contact to suppress the leakage current of semiconductor γ-ray detectors and improve their energy resolution, it is successfully employed the fact that the formation of a Schottky barrier is determined not only by the difference in the electrode and semiconductor work functions but also affected by the semiconductor surface state. Oxygen plasma (OP) treatment has been used to modify the surface states of CdSe single crystals (SCs) prior to the Au electrode deposition, thereby creating a Schottky contact at the metal-semiconductor interface. The -type Schottky contact formation has been confirmed by the - characteristics and ultraviolet photoelectron spectroscopy analysis.
View Article and Find Full Text PDFBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive lymphohematopoietic malignancy associated with poor prognosis. We aimed to improve the understanding of BPDCN, explore its prognostic significance, and identify potential therapeutic targets. Data from 14 BPDCN patients were retrospectively collected and analyzed, focusing on their clinicopathological characteristics, diagnostic features, immunophenotype, treatment regimens, and prognostic factors.
View Article and Find Full Text PDFBackground: In April 2020, Japan's revised Health Promotion Act (HPA) banned cigarette smoking and heated tobacco products (HTP) use in indoor public places but exempted small establishments and permitted smoking-designated/HTP-designated rooms. This pre-post study evaluated the effectiveness of the HPA.
Methods: Data were from waves 1 to 4 (2018-2021) of the International Tobacco Control Japan Surveys among a national cohort of adults who smoke cigarettes, use HTPs and do not use any tobacco products.
The stability of supported nano-metal catalysts holds significant importance in both scientific and economic practice, beyond the long pursuit of enhanced activity. While previous efforts have concentrated on augmenting the interaction between nano-metals and carriers, in the thermodynamic macro-perspective, to achieve optimized repression upon particle migration coalescence and Ostwald ripening, nevertheless, the microscale kinetics of migrating catalyst particles driven by the reaction remains unknown. In this work, the migration of nano-copper particles is investigated during hydrogen oxidation reaction by utilizing high spatiotemporal resolution of environmental transmission electron microscopy.
View Article and Find Full Text PDFAims: Phyllodes tumours (PTs) are relatively common fibroepithelial tumours comprising epithelial and stromal component. Usually, PTs show a spindle cell morphology with a fibroblast phenotype, while some tumour cells exhibit epithelioid morphological features and sarcomatoid transformation. However, the molecular characteristics of this morphology subset remain unclear.
View Article and Find Full Text PDFAccurate description of nonadiabatic dynamics of molecules at metal surfaces involving electron transfer has been a long-standing challenge for theory. Here, we tackle this problem by first constructing high-dimensional neural network diabatic potentials including state crossings determined by constrained density functional theory, then applying mixed quantum-classical surface hopping simulations to evolve coupled electron-nuclear motion. Our approach accurately describes the nonadiabatic effects in CO scattering from Au(111) without empirical parameters and yields results agreeing well with experiments under various conditions for this benchmark system.
View Article and Find Full Text PDFAutoreactive CD8 T cells play a key role in type 1 diabetes (T1D), but the antigen spectrum that activates autoreactive CD8 T cells remains unclear. Endoplasmic reticulum stress (ERS) has been implicated in β-cell autoantigen generation. Here, we analyzed the major histocompatibility complex class I (MHC-I)-associated immunopeptidome (MIP) of islet β-cells under steady and ERS conditions and found that ERS reshaped the MIP of β-cells and promoted the MHC-I presentation of a panel of conventional self-peptides.
View Article and Find Full Text PDFEpigenomic imbalance drives abnormal transcriptional processes, promoting the onset and progression of cancer. Although defective gene regulation generally affects carcinogenesis and tumor suppression networks, tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes, which may have significant implications for the development and application of epigenetic therapy, cancer immunotherapy, and their combinations. Herein, we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes, DNA methylation, histone post-translational modification, and chromatin structure in tumor immunogenicity, and introduce these epigenetic research methods.
View Article and Find Full Text PDFDimethyl disulfide (DMDS) is a common odor pollutant with an extremely low olfactory threshold. Highly sensitive and selective detection of DMDS in ambient humid air background, by metal oxide semiconductor (MOS) sensors, is highly desirable to address the increased public concern for health risk. However, it has still been a critical challenge up to now.
View Article and Find Full Text PDFThough considerable progress has been achieved on gas molecule recognition by electronic nose (e-nose) comprised of nonselective (metal oxide) semiconductor chemiresistors, extracting adequate molecular features within short time (<1 s) remains a big obstacle, which hinders the emerging e-nose applications in lethal or explosive gas warning. Herein, by virtue of the ultrafast (∼20 μs) thermal relaxation time of self-heated WO-based chemiresistors fabricated via oblique angle deposition, instead of external heating, self-heating temperature modulation has been proposed to generate sufficient electrical response features. Accurate discrimination of 12 gases (including 3 xylene isomers with the same function group and molecular weight) has been readily achieved within 0.
View Article and Find Full Text PDFBackground: Blood perfusion of the optic nerve (ON) plays a key role in many optic neuropathies. Microvascular changes precede or accompany neuronal changes, and detecting these changes at an early stage may facilitate early treatment to avoid blindness. However, the quantification of ON blood perfusion remains a challenge.
View Article and Find Full Text PDFIntroduction: Heated tobacco products (HTPs) and nicotine vaping products (NVPs) both are legal consumer products in the Republic of Korea. Little is known about perceptions of harmfulness of HTPs and NVPs relative to cigarettes in South Korea among adults who smoke, and how exposure to marketing may be associated with harmfulness perceptions.
Methods: This study used data from the 2020 International Tobacco Control (ITC) Korea Survey, and included 3713 adult (aged 19 years) cigarette smokers who were: 1) exclusive smokers (n=1845); 2) dual HTP + cigarette consumers (n=1130); 3) dual NVP + cigarette consumers (n=224); and 4) triple consumers (all three products, n=514).
Introduction: In March 2020, the US Food and Drug Administration (FDA) finalized new pictorial health warnings (PHWs), covering 50% of the front and back of the pack; however, legal challenges from cigarette manufacturers have prevented the new warnings from being implemented. About 70% of adults in the general US population support PHWs. This study assessed support for PHWs in 2016, 2018 and 2020 among US adults (aged ≥18 years) who currently smoke or formerly smoked cigarettes.
View Article and Find Full Text PDFIn this study, α-L-arabinofuranosidase (AF) from Aspergillus awamori was heterologously expressed in Pichia pastoris X33, with a 1-fold increase in AF activity after codon and vector optimization. AF remained stable at 60-65 °C and displayed a broad pH stability range of 2.5-8.
View Article and Find Full Text PDFIEEE J Biomed Health Inform
May 2023
As powerful tools deep neural networks have been successfully adopted for nuclei detection in histopathology images, whereas require the same probability distribution between training and testing data. However, domain shift among histopathology images widely exists in real-world applications and severely deteriorates the detection performance of deep neural networks. Despite encouraging results of existing domain adaptation methods, there remain challenges for cross-domain nuclei detection task.
View Article and Find Full Text PDFUV photoactivation has been widely employed to trigger the response of semiconductor chemiresistors at room temperature (RT). Generally, continuous UV (CU) irradiation is applied, and an apparent maximal response could be obtained via optimizing UV intensity. However, owing to the conflicting roles of (UV) photoactivation in the gas response process, we do not think the potential of photoactivation has been fully explored.
View Article and Find Full Text PDFChemiresistive gas sensors generally surfer from low selectivity, inferior anti-humidity, low response signal or signal-to-noise ratio, severely limiting the precise detection of chemical agents. Herein, we exploit high-performance gas sensors based on topological insulator BiSe that is distinguished from conventional materials by robust metallic surface states protected by time-reversal symmetry. In the presence of Se vacancies, BiSe nanosheets exhibit excellent gas sensing capability toward NO, with a high response of 93% for 50 ppm and an ultralow theoretical limit of detection concentration about 0.
View Article and Find Full Text PDFObjective: The objective of the current investigation was to examine associations between symptomatic COVID-19 history, neurocognitive function, and psychiatric symptoms using cognitive task performance, functional brain imaging, and a prospective population survey.
Methods: Study 1 was a laboratory study conducted between 3 May 2022 and 16 Nov 2022 involving 120 fully vaccinated community dwelling adults between 18 and 84 years of age (age = 31.96 ( = 20.
A thermally evaporated hydrophobic PDMS membrane could significantly mitigate humidity interference/poisoning (without a decline in response at 50% RH for nearly 3 months) and enhance the selectivity of a CuCrO chemiresistor toward erosive HS, offering an avenue for the practical applications of (HS) chemiresistors in an ambient humid air atmosphere.
View Article and Find Full Text PDFMetal oxide semiconductor (MOS)-based chemiresistors have been widely used for detecting harmful gases in many industrial and indoor/outdoor applications, which possess the advantages of small size, low cost, integratability, and ease of use. However, power consumption has become a critical parameter for practical applications. Several methods have been explored to reduce power consumption including reducing the operation temperature, use of micro-electro-mechanical systems (MEMS), and self-heating working mode.
View Article and Find Full Text PDFObjective: To examine the impact of menthol cigarette bans on use and purchasing of illicit cigarettes among menthol and non-menthol smokers in seven Canadian provinces.
Methods: Data from 1098 non-menthol smokers and 138 menthol smokers in Canada who completed the ITC Four Country Smoking and Vaping Survey in 2016 (pre-ban) and 2018 (post-ban). Brand validation analysis was conducted to (1) compare self-reported use of menthols versus actual use of menthols as regular brand, and verify self-reported purchasing of menthols among pre-ban menthol smokers at post-ban; and (2) assess pre-post ban changes in purchasing of illicit cigarettes from First Nations reserves among non-menthol smokers and menthol smokers.