Inhibition of hepatocellular carcinoma cell proliferation through regulation of the Cell Cycle, AGE-RAGE, and Leptin signaling pathways by a compound formulation comprised of andrographolide, wogonin, and oroxylin A derived from Andrographis Paniculata(Burm.f.) Nees.

Ethnopharmacological Relevance: In 2020, liver cancer contributed to approximately 0.9 million new cases and 0.83 million deaths, making it the third leading cause of mortality worldwide.

Coral-like BaTiO-Filled Polymeric Composites as Piezoelectric Nanogenerators for Movement Sensing.

Piezoelectric nanogenerators have prospective uses for generating mechanical energy and powering electronic devices due to their high output and flexible behavior. In this research, the synthesis of the three-dimensional coral-like BaTiO (CBT) and its filling into a polyvinylidene fluoride (PVDF) matrix to obtain composites with excellent energy harvesting properties are reported. The CBT-based PENG has a 163 V voltage and a 16.

E2F1‑mediated RAB34 upregulation accelerates the proliferation and inhibits the cell cycle arrest and apoptosis of acute myeloid leukemia cells.

Acute myeloid leukemia (AML) is a malignant disease that is mainly arisen from myeloid stem/progenitor cells. The pathogenesis of AML is complex. Ras-related protein member RAS oncogene GTPases (RAB) 34 protein has been reported to serve an important role in the development of cancer.

A Mousepad Triboelectric-Piezoelectric Hybrid Nanogenerator (TPHNG) for Self-Powered Computer User Behavior Monitoring Sensors and Biomechanical Energy Harvesting.

Hybrid nanogenerators based on the principle of surface charging of functional films are significant in self-powering sensing and energy conversion devices due to their multiple functions and high conversion efficiency, although applications remain limited due to a lack of suitable materials and structures. Here, we investigate a triboelectric-piezoelectric hybrid nanogenerator (TPHNG) in the form of a mousepad for computer user behavior monitoring and energy harvesting. Triboelectric and piezoelectric nanogenerators with different functional films and structures work independently to detect sliding and pressing movements, and the profitable coupling between the two nanogenerators leads to enhanced device outputs/sensitivity.

Computational analysis for identification of early diagnostic biomarkers and prognostic biomarkers of liver cancer based on GEO and TCGA databases and studies on pathways and biological functions affecting the survival time of liver cancer.

Background: Liver cancer is the sixth most commonly diagnosed cancer and the fourth most common cause of cancer death. The purpose of this work is to find new diagnostic biomarkers or prognostic biomarkers and explore the biological functions related to the prognosis of liver cancer.

Methods: GSE25097 datasets were firstly obtained and compared with TCGA LICA datasets and an analysis of the overlapping differentially expressed genes (DEGs) was conducted.

Enhanced performances of triboelectric nanogenerators by filling hierarchical flower-like TiO particles into polymethyl methacrylate film.

In this study, a flower-like TiO filled polymethyl methacrylate (PMMA) composite is presented as a positive tribo-material to produce an excellent-performance triboelectric nanogenerator (TENG). By working in conjunction with polydimethylsiloxane (PDMS), the flat-surface PDMS/PMMA-flower TiO TENG generates a voltage of 1200 V, a current of 139 mA m and an output power of 34.85 W m, showing significant enhancement compared with its counterpart utilizing neat PMMA as the positive tribo-material under the same operating conditions, whose voltage is 620 V, current is 78 mA m and output power is 13.

Orientation Dependence of Elastic and Piezoelectric Properties in Rhombohedral BiFeO₃.

Through a coordinate transformation approach, crystal orientation dependences of elastic and piezoelectric properties at room temperature have been investigated in a three-dimensional space for rhombohedral bismuth ferrite (BiFeO₃). Elastic constants (stiffnesses) , , c and piezoelectric constants , , along arbitrary orientations were obtained based on crystalline asymmetry characteristics of point group BiFeO₃. Parameters along specific orientations obtaining the largest values were presented.

Oridonin induces apoptosis through the mitochondrial pathway in human gastric cancer SGC-7901 cells.

Oridonin is one of the most important antitumor active ingredients of Rabdosia rubescens. Recently published studies from our laboratory have demonstrated that oridonin was able to arrest human gastric cancer SGC-7901 cells at G2/M phase. However, little is known about inducing apoptosis in gastric cancer.

[Survey on Echinococcosis in Maqing County of Qinghai Province].

Objective: To understand the status of echinococcosis in Maqing County of Qinghai Province in order to facilitate echinococcosis control in this region.

Methods: Ultrasonic scanning and indirect hemagglutination assay were used to detect echinococcosis infection in residents >1 year old, according to the People's Republic of China Health Industry Standard--Diagnostic Criteria for Hydatid Disease (WS257-2006). Meanwhile, ELISA was used o detect the Echinococcus antigen in dog's feces collected in Youyun, Dangluo and Xiadawu townships.

Screening antitumor bioactive fraction from Sauromatum giganteum (Engl.) Cusimano & Hett and sensitive cell lines with the serum pharmacology method and identification by UPLC-TOF-MS.

Sauromatum giganteum (Engl.) Cusimano & Hett Tuber are used in Chinese folklore medicine for treatment of neoplasms. However, the claim has not been scientifically validated.

Ethanol but not aqueous extracts of tubers of Sauromatum Giganteum(Engl.) Cusimano and Hett inhibit cancer cell proliferation.

Background: Both alcohol and aqueous extracts of Sauromatum giganteum(Engl.) Cusimano and Hett, the dried root tuber of which is named Baifuzi in Chinese, have been used for folklore treatment of cancer in Northeast of China. However, little is known about which is most suitable to the cancer therapy.

One-atmosphere aqueous-solution synthesis of trimolybdate nanomaterials and the feasibility for mass production.

Mass production of low-cost functional nanomaterials is an important issue for the development of nanoscience and nanotechnology. With rich structural, physical and chemical properties, polyoxometalates are important functional materials for both industrial applications and fundamental research. We presented a family of alkali trimolybdate nanowires and nanorods that were synthesized by a one-atmosphere aqueous solution method from a mixture of two solutions, one consisting of (NH4)6Mo7O24 x 4H2O and the other of Li+, Na+, K+ and Rb+ ions, respectively.