Low-valent germanium and tin hydrides as catalysts for hydroboration, hydrodeoxygenation (HDO), and hydrodesulfurization (HDS) of heterocumulenes.

The low-valent germanium and tin hydrides, [LMH; L = {(ArHN)(ArN)-CN-C(NAr)(NHAr); Ar = 2,6-Et-CH}; M = Ge; (Ge-1), Sn (Sn-2)] bearing bis-guanidinato anions are employed as catalysts for chemoselective reduction of heterocumulenes hydroboration reactions. This protocol demonstrates that a wide range of carbodiimides (CDI), isocyanates, isothiocyanates, and isoselenocyanates undergo partial reduction, yielding the corresponding -boryl formamidine, -boryl formamide, -boryl thioformamide, and -boryl selenoformamide products, respectively. Isocyanates and isothiocyanates are further converted into -boryl methyl amines through hydrodeoxygenation (HDO) and hydrodesulfurization (HDS) reactions in the presence of catalyst Ge-1.

Zinc hydride catalyzed hydroboration of esters.

The conjugated bis-guanidinate (CBG)-supported zinc hydride {LZnH}; L = {(ArHN)(ArN)-CN-C(NAr)(NHAr); Ar = 2,6-Et-CH} (I) is utilized as a catalyst for the hydroboration of esters with pinacolborane (HBpin) under mild reaction conditions. Various aryl and alkyl substrates containing electron-donating, withdrawing, and cyclic groups of esters are effectively converted into alkoxy boronate esters as products upon hydroboration. Furthermore, stoichiometric experiments have been performed to understand the plausible reaction mechanism for the hydroboration of esters.

Synthesis of low oxidation state zinc(I) complexes and their catalytic studies in the dehydroborylation of terminal alkynes.

A new example of a structurally characterized conjugated bis-guanidinate (CBG) supported zinc(I) dimer, , LZnZnL (3) (L = {(ArNH)(ArN)-CN-C(NAr)(NHAr)}; Ar = 2,6-Et-CH) with a Zn-Zn bond is reported. Moreover, homoleptic (3) and heteroleptic (Cp*ZnZnL, 2, (Cp* = 1,2,3,4,5-pentamethyl cyclopentadienide)) zinc(I) dimers are used as precatalysts in the dehydroborylation of a wide array of terminal alkynes. Furthermore, the active catalyst, CBG zinc acetylide (LZn-CC-Ph-4-Me), (5), is isolated which is confirmed by X-ray crystal structure analysis.

Pharmacological evaluation of (Pers.) on bronchial asthma.

Objective: The present study was to investigate the antiasthmatic potential from the flavonoid fraction of fruit (FFALF) to validate its traditional claim.

Materials And Methods: The antiasthmatic activity of FFALF was evaluated by histamine or acetylcholine-induced bronchospasm model in guinea pigs, compound 48/80 induced mast cell degranulation in albino rats and histamine-induced tracheal contraction in guinea pig. The preconvulsion dyspnea time at 0 and 7 day at the dose of 100 and 200 mg/kg in guinea pig's bronchospasm model, the percentage of granulated and degranulated mast cell at the dose of 500, 750, and 1000 μg/ml in rats and tracheal contraction at the dose of 500, 750, and 1000 μg/ml in guinea pig were measured and compared with respective control groups.

Effects of L. leaves extract on anxiety, depression and memory.

Objective: The present study was carried out to investigate the neuropharmacological activities of ethyl acetate extract of (EAMP) leaves on anxiety, depression and memory in a mouse model.

Materials And Methods: Anti-anxiety potential of EAMP was evaluated by elevated plus maze (EPM), light-dark box (LDB) and social interaction (SI) tests in mice.Anti-depressant potential of EAMP was evaluated by forced swimming (FST), tail suspension (TST), and open field tests (OFT).

In vitro and In vivo Antioxidant Evaluation and Estimation of Total Phenolic, Flavonoidal Content of Mimosa pudica L.

Objective: Mimosa pudica Linn. (Mimosaceae) is traditionally used as a folk medicine to treat various ailments including convulsions, alopecia, diarrhea, dysentery, insomnia, tumor, wound healing, snake bite, etc., Here, the study was aimed to evaluate the antioxidant potential of M.