Publications by authors named "Ganesh P Pawar"
Article Synopsis
- A Rh(III) catalyst facilitates a unique [4 + 1] cyclization process involving 2-arylbenzimidazoles and alkynoates, leading to the formation of benzimidazole-fused isoindoles through a series of C-H activation, ortho-alkenylation, and intramolecular annulation steps.
- The reaction with an internal alkyne ester generates benzo[4,5]imidazo[2,1-]isoindole acetate, while a Ru catalyst is used with an internal alkyne amide to yield benzo[4,5]imidazo[2,1-]isoindole acetamide.
- This approach highlights a shift
Benzothiazine 1,1-dioxide (BTDO) is a privileged chemical motif, and its metal-free domino access is in high demand. Current BTDO production methods require costly metal catalysts or harsh reaction conditions. A facile domino approach to BTDO via a water-gas shift reaction (WGSR) employing sodium 2-nitrobenzenesulfinates and α-bromo ketones is presented.
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- SARS-CoV2 causes COVID-19, and low levels of type I and III interferons alongside high inflammatory mediators worsen the disease's severity.
- Controlled inflammation and optimal interferon production are crucial to mitigate COVID-19's harmful effects, as severe inflammation can lead to acute respiratory distress syndrome (ARDS).
- The review emphasizes the importance of Toll-like receptor 7 and 8 pathways in regulating interferon and inflammation, suggesting that TLR7/8 agonists could be promising therapies to reduce COVID-19 severity.
Terminal Respiratory Oxidases: A Targetables Vulnerability of Mycobacterial Bioenergetics?
Front Cell Infect Microbiol
June 2021
Recently, ATP synthase inhibitor Bedaquiline was approved for the treatment of multi-drug resistant tuberculosis emphasizing the importance of oxidative phosphorylation for the survival of mycobacteria. ATP synthesis is primarily dependent on the generation of proton motive force through the electron transport chain in mycobacteria. The mycobacterial electron transport chain utilizes two terminal oxidases for the reduction of oxygen, namely the supercomplex and the cytochrome oxidase.
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