Small bowel intussusception: Does being transient make it less problematic? A case report.

Introduction: Small bowel intussusception is challenging to diagnose as it does not always declare itself. There is not enough evidence in the literature regarding the management of the same. This case report investigates relevant management options to ensure appropriate and timely treatment.

Nitrogen, sulfur, and phosphorus Co-doped carbon dots-based ratiometric chemosensor for highly selective sequential detection of Al and Fe ions in logic gate, cell imaging, and real sample analysis.

Heteroatom-doped photoluminescent (PL) carbon dots (CDs) have recently gained attention as optical sensors due to their excellent tunable properties. In this work, we propose a one-pot hydrothermal synthesis of PL nitrogen (N), sulfur (S), and phosphorus (P) co-doped carbon dots (NSP-CDs) using glutathione and phosphoric acid (HPO) as precursors. The synthesized NSP-CDs were characterized using different spectroscopic and microscopic techniques, including ultraviolet-visible (UV-Vis) spectroscopy, fluorescence spectroscopy, Fourier-transform infrared (FTIR), X-ray powder diffraction (XRD), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS) analysis.

An E-Survey of Current Voice Therapy Practices Amongst Speech Language Pathologists (SLPs) in India.

In India, Speech Language Pathologists (SLPs) generally work with ENT surgeons and use a variety of treatment approaches, service delivery methods, feedback modes, and outcome measures in clinical practice while dealing with voice disorders. The practice preferences of the SLPs are based on theoretical and practical exposure during their graduate course, guidance from professional bodies, evidence-based practices, etc. The facilities in the work setting also determine the practice style of the SLP.

RCSB Protein Data Bank (RCSB.org): delivery of experimentally-determined PDB structures alongside one million computed structure models of proteins from artificial intelligence/machine learning.

The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB), founding member of the Worldwide Protein Data Bank (wwPDB), is the US data center for the open-access PDB archive. As wwPDB-designated Archive Keeper, RCSB PDB is also responsible for PDB data security. Annually, RCSB PDB serves >10 000 depositors of three-dimensional (3D) biostructures working on all permanently inhabited continents.

Compulsive buying behavior and its association with emotional distress, depression, and impulsivity in general population: an online survey.

Background: Compulsive buying behavior or pathological buying is increasingly being recognized as a psychiatric disorder, and various psychosocial factors have been proposed to contribute to this problem. This study aimed to identify the association between compulsive buying behavior, stress, anxiety, depression, and impulsivity.

Methods: This cross-sectional, online survey used Google Forms to collect sociodemographic and clinical details of the participants between June 2021 and August 2021.

Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer.

Highly regenerative tissues continuously produce terminally differentiated cells to replace those that are lost. How they orchestrate the complex transition from undifferentiated stem cells towards post-mitotic, molecularly distinct and often spatially segregated differentiated populations is not well understood. In the adult skin epidermis, the stem cell compartment contains molecularly heterogeneous subpopulations whose relationship to the complete trajectory of differentiation remains unknown.

Systematic analysis of membrane contact sites in uncovers modulators of cellular lipid distribution.

Actively maintained close appositions between organelle membranes, also known as contact sites, enable the efficient transfer of biomolecules between cellular compartments. Several such sites have been described as well as their tethering machineries. Despite these advances we are still far from a comprehensive understanding of the function and regulation of most contact sites.

Facile construction of cost-effective zinc-aluminium polymeric framework for efficient removal of selective both drug and dye from an aqueous medium.

A novel aluminium (Al) and its active alloys are extensively been used in nearly all areas owing to their cost-effectiveness. But when it is subjected to an aqueous medium, gets corroded through a chemical response. In this paper, a novel framework was fabricated by copolymer coating over on Al and loaded with zinc via electro polymerization and electrodeposition method ([EDA- OPDA]Al@Zn).

Systematic review and meta-analysis of oral squamous cell carcinoma associated oral microbiome.

The intersection between the human oral microbiome and oral health is an emerging area of study which has gained momentum over the last decade. This momentum has motivated a search for associations between the oral microbiome and oral cancer, in hopes of identifying possible biomarkers that facilitate earlier diagnosis and improved prognosis for patients with that disease. The present study examined the relationship between the microbiome in the human oral cavity and oral squamous cell carcinoma (OSCC).

Enhancement in the visible light induced photocatalytic and antibacterial properties of titanium dioxide codoped with cobalt and sulfur.

In this study, the sol-gel technique was used to develop Cobalt Sulfur codoped Titanium Dioxide (Co-S codoped TiO) photocatalysts. For structural analysis of the prepared resultant TiO samples, XRD, FTIR, UV-Vis DRS, SEM, HR-TEM and EDX measurements were used to describe the produced photocatalysts. The characterization findings indicate that the synthesized nanoparticles possessed great crystallinity, high purity, and superior optical characteristics.

Intranasal nanoemulsion adjuvanted S-2P vaccine demonstrates protection in hamsters and induces systemic, cell-mediated and mucosal immunity in mice.

With the rapid progress made in the development of vaccines to fight the SARS-CoV-2 pandemic, almost >90% of vaccine candidates under development and a 100% of the licensed vaccines are delivered intramuscularly (IM). While these vaccines are highly efficacious against COVID-19 disease, their efficacy against SARS-CoV-2 infection of upper respiratory tract and transmission is at best temporary. Development of safe and efficacious vaccines that are able to induce robust mucosal and systemic immune responses are needed to control new variants.

Using the Sleeping Beauty (SB) Transposon to Generate Stable Cells Producing Enveloped Virus-Like Particles (eVLPs) Pseudotyped with SARS-CoV-2 Proteins for Vaccination.

The Sleeping Beauty (SB) transposon system is an efficient non-viral tool for gene transfer into a variety of cells, including human cells. Through a cut-and-paste mechanism, your favorite gene (YFG) is integrated into AT-rich regions within the genome, providing stable long-term expression of the transfected gene. The SB system is evolving and has become a powerful tool for gene therapy.

RCSB Protein Data bank: Tools for visualizing and understanding biological macromolecules in 3D.

Now in its 52nd year of continuous operations, the Protein Data Bank (PDB) is the premiere open-access global archive housing three-dimensional (3D) biomolecular structure data. It is jointly managed by the Worldwide Protein Data Bank (wwPDB) partnership. The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) is funded by the National Science Foundation, National Institutes of Health, and US Department of Energy and serves as the US data center for the wwPDB.

TRAF3IP2-IL-17 Axis Strengthens the Gingival Defense against Pathogens.

Recent genome-wide association studies have suggested novel risk loci associated with periodontitis, which is initiated by dysbiosis in subgingival plaque and leads to destruction of teeth-supporting structures. One such genetic locus was the tumor necrosis factor receptor-associated factor 3 interacting protein 2 (), a gene encoding the gate-keeping interleukin (IL)-17 receptor adaptor. In this study, we first determined that carriers of the lead exonic variant rs13190932 within the locus combined with a high plaque microbial burden was associated with more severe periodontitis than noncarriers.

Durability of antibodies post vaccination with two doses of inactivated BBIBP-CorV vaccine.

Background: Breakthrough infections post-COVID-19 vaccination occur with the emerging variants of the SARS-CoV virus which might be either due to the newer variants escaping immune response or the waning of antibodies over time. However, there is lack of long-term follow-up evidence on the waning of immune response following inactivated COVID-19 vaccine.

Methods: A retrospective, observational study was conducted on serum samples of individuals who had received two doses of BBIBP-CorV vaccine.

The Need for Nicotine De-addiction Services among Newly Diagnosed Tobacco-Related Head and Neck Cancer Patients, South India.

Objectives: This study aimed to determine the proportion of tobacco-related head and neck cancer patients in need of nicotine de-addiction services at the time of diagnosis and factors associated with it.

Methods: Facility-based cross-sectional study was conducted in a tertiary care center. Tobacco-related head and neck cancer patients with a past and present history of tobacco usage registered in cancer clinic from March 2016 to February 2017 were recruited.

Sustainable utilization of unavoidable food waste into nutritional media for the isolation of bacterial culture for the removal of heavy metals.

This study aims to reuse food waste (FW) as growth media for bacterial cultures for bioremediation of heavy metal. The best natural medium was selected based on the carbon, nitrogen, and other elements. The batch culture of Comamonas terrae showed growth stability for 16 days in the pig bone medium.

Microbes for Archaeological Wood Conservation.

This project focuses on innovative biological methods of extraction for the preservation of waterlogged wood suffering from salt precipitation and acidification. The principal investigator and her team proposed to exploit biomineralization capacities of some bacteria for anticipating the extraction of iron and sulfur compounds when wood is still wet. A comprehensive assessment of the extraction performances achieved on wood objects from lake and marine environments will allow a versatile extraction method to be proposed to end-users.

Supramolecular bioamphiphile facilitated bioemulsification and concomitant treatment of recalcitrant hydrocarbons in petroleum refining industry oily waste.

Bioremediation of real-time petroleum refining industry oily waste (PRIOW) is a major challenge due to the poor emulsification potential and oil sludge disintegration efficiency of conventional bioamphiphile molecules. The present study was focused on the design of a covalently engineered supramolecular bioamphiphile complex (SUBC) rich in hydrophobic amino acids for proficient emulsification of hydrocarbons followed by the concomitant degradation of total petroleum hydrocarbons (TPH) in PRIOW using the hydrocarbonoclastic microbial bio-formulation system. The synthesis of SUBC was carried out by pH regulated microbial biosynthesis process and the yield was obtained to be 450.

SARS-CoV-2 main protease (3CL) interaction with acyclovir antiviral drug/methyl-β-cyclodextrin complex: Physiochemical characterization and molecular docking.

During the current outbreak of the novel coronavirus disease 2019 (COVID-19), researchers have examined several antiviral drugs with the potential to inhibit the proliferation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The antiviral drug acyclovir (AVR), which is used to treat COVID-19, in complex with methyl-β-cyclodextrin (Mβ-CD) was examined in the solution and solid phases. UV-visible and fluorescence spectroscopic analyses confirmed that the guest (AVR) was included inside the host (Mβ-CD) cavity.

Focused attention meditation in healthy adults: A systematic review and meta-analysis of cross-sectional functional MRI studies.

Meditation trains the mind to focus attention towards an object or experience. Among different meditation techniques, focused attention meditation is considered foundational for more advanced practices. Despite renewed interest in its functional neural correlates, there is no unified neurocognitive model of focused attention meditation developed via quantitative synthesis of contemporary literature.

Microstructure, Mechanical and Wear Behaviour of Deep Cryogenically Treated EN 52 Silchrome Valve Steel.

This study has compared the performance of cryogenically processed EN 52 Silchrome valve steel with untreated material. After completing the standard heat treatment process, EN 52 steel material specimens are subjected to a deep cryogenic process with varying soaking temperatures. The parameters of the deep cryogenic procedure were changed to find the best wear qualities.