Publications by authors named "Ganendra Raj Mohan"
Background: Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo-ovarian high-grade serous carcinoma (HGSC). Smaller studies have revealed unfavorable associations for CCNE1 amplification and CCNE1 overexpression with survival, but to date no large-scale, histotype-specific validation has been performed. The hypothesis was that high-level amplification of CCNE1 and CCNE1 overexpression, as well as a combination of the two, are linked to shorter overall survival in HGSC.
View Article and Find Full Text PDFGene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes.
Clin Cancer Res
December 2022
Article Synopsis
- Advanced-stage mucinous ovarian carcinoma (MOC) is difficult to treat due to poor chemotherapy response and the need for better biomarkers for stage I treatment, leading researchers to analyze gene-expression and clinicopathologic data.
- A study identified 19 genes potentially linked to patient prognosis, validating findings with data from 604 patients that included different types of tumors.
- Results indicated that an infiltrative pattern of invasion correlates with worse survival, and higher levels of certain proteins (THBS2 and TAGLN) are associated with poor prognosis, suggesting both may be useful for determining treatment approaches.
Background: In 2016 universal screening with mismatch repair protein immunohistochemistry in all newly diagnosed endometrial carcinomas was introduced in Western Australia.
Objective: To compare the prevalence of Lynch syndrome associated endometrial carcinomas between 2016 and 2019 with a historical control (2015). Additionally, to compare the number of cases appropriately referred for genetic assessment.
Aim: Our objective was to assess clinical and pathological factors associated with a final diagnosis of endometrial carcinoma in patients with atypical endometrial hyperplasia with a particular emphasis on the grading of atypia.
Materials And Methods: A retrospective review over five years on patients (N = 97) who underwent hysterectomy for a diagnosis of atypical endometrial hyperplasia at a statewide public tertiary gynaecologic oncology centre. Clinical and pathological characteristics were obtained.
Article Synopsis
- - The study investigated the effectiveness of loop electrosurgical excision procedure (LEEP) versus cold knife cone biopsy (CKC) in treating adenocarcinoma in situ (AIS) of the cervix by comparing margin status, specimen size, and fragmentation after the procedures.
- - Conducted as the EXCISE Trial across seven hospitals in Australia and New Zealand, the trial randomly assigned 40 women aged 18 to 45 with AIS to either LEEP or CKC and assessed outcomes like margin involvement and post-operative complications.
- - Results showed no significant differences in margin involvement or specimen size between the two methods, but CKC had higher post-operative complications compared to LEEP, indicating a need for further research to definitively compare
Background: Approximately 20% of women with gynecologic cancers are under age 40 and with delayed childbearing, women may be diagnosed before their first pregnancy. Although fertility preservation is a priority for many women, attitudes to conception have not previously been investigated in these patients or their partners. We explored attitudes to conception in partners and young women, following fertility preserving treatment for gynecologic cancers.
View Article and Find Full Text PDFBackground: There are significant geographic inequalities in cancer survival with poorer survival rates in non-metropolitan areas compared to major cities. Physical activity (PA) can reduce cancer recurrence and prevent cardiovascular disease. However, few survivors participate in sufficient PA and the prevalence of inactivity is significantly higher in non-metropolitan survivors.
View Article and Find Full Text PDFIntroduction: Physically active cancer survivors have substantially less cancer recurrence and improved survival compared with those who are inactive. However, the majority of survivors (70%-90%) are not meeting the physical activity (PA) guidelines. There are also significant geographic inequalities in cancer survival with poorer survival rates for the third of Australians who live in non-metropolitan areas compared with those living in major cities.
View Article and Find Full Text PDFPurpose: The study purpose was to investigate the acceptability and utility of, and preference for, wearable activity trackers (WATs) amongst cancer survivors living in regional and remote areas of Western Australia.
Methods: Twenty participants were recruited (Mean age = 63 years, SD = 13) to test two to three trackers from five available models (Fitbit Alta, Garmin Vivofit 2, Garmin Vivosmart, Polar loop 2 and Polar A300). Participants wore each device for two weeks, followed by a one-week washout period between devices.