A machine learning model for predicting abnormal liver function induced by a Chinese herbal medicine preparation (Zhengqing Fengtongning) in patients with rheumatoid arthritis based on real-world study.

Objective: Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects the small joints of the whole body and degrades the patients' quality of life. Zhengqing Fengtongning (ZF) is a traditional Chinese medicine preparation used to treat RA. ZF may cause liver injury.

6-month regimen of isoniazid prevention therapy for tuberculosis among people living with human immunodeficiency virus in minority areas of China: a 3-year prospective cohort study.

Introduction: As China is scaling up tuberculosis preventive therapy (TPT) for people living with HIV (PLHIV) in its national programmes, the objective of this study was to evaluate the feasibility and performance of 6-month regimen of isoniazid monotherapy (6H) in terms of preventive therapy acceptance, adherence, effectiveness and outcomes in minority areas with a high burden of tuberculosis (TB) and HIV/AIDS.

Method: A prospective observational cohort study was initiated among 461 PLHIV in Butuo County after ruling out active TB (ATB) and followed up for up to 3 years to collect incidence events in real-world settings. TB incidence and protective rates were calculated.

Expert consensus on sequential surgery following conversion therapy based on combination of immune checkpoint inhibitors and antiangiogenic targeted drugs for advanced hepatocellular carcinoma (2024 edition).

Up to half of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage, for which effective treatment options are lacking, resulting in a poor prognosis. Over the past few years, the combination of immune checkpoint inhibitors and anti-angiogenic targeted therapy has proven highly efficacious in treating advanced HCC, significantly extending patients' survival and providing a potential for sequential curative surgery. After sequential curative hepatectomy or liver transplantation following conversion therapy, patients can receive long-term survival benefits.

[Drift Correction Method of Wastewater Treatment Model Based on Transfer Learning Across Time Scales].

Data is the core foundation of intelligent operation and maintenance, but currently, there is generally insufficient data for wastewater treatment plants, and the status of wastewater treatment systems dynamically evolves with the changes in the internal and external environment. The intelligent operation and maintenance of wastewater plants face difficulties in modeling and model drift caused by system evolution. In response to this issue, the summer and winter seasons with significant differences in wastewater temperature, wastewater quality, and microbial status were selected as typical comparison scenarios.

[Comprehensive Analysis and Emission Reduction Pathway of GHG Emissions at a Wastewater Treatment Plant in Suzhou].

Taking a sewage treatment plant in Suzhou City, Jiangsu Province, as an example, the greenhouse gas （GHG） emissions generated in the sewage treatment system were calculated using the carbon balance method and the emission factor method. The environmental impacts and economic aspects of different treatment units in wastewater treatment plants were analyzed using life cycle assessment, cost-benefit analysis, and data envelopment analysis models, and emission reduction pathways were proposed. The results indicated that the total GHG emissions （in terms of CO） from a certain municipal wastewater treatment plant in Suzhou were 6 653.

[Spatial-temporal Evolution and Influencing Factors of Land Use Carbon Emissions in Shandong Province].

Exploring the spatial-temporal evolution characteristics of land use carbon emissions and their influencing factors is of great significance for the optimization of land use structure, the formulation of emission reduction policies, and the development of a regional low-carbon economy. Based on land cover and energy consumption data, a multi-parameter land use carbon emission accounting system was constructed to calculate land use carbon emissions in Shandong Province. Moreover, the spatial-temporal evolution and influencing factors of land use carbon emissions were analyzed based on the Gini coefficient and logarithmic mean Divisia index.

Gestational exposure to carbon black nanoparticles triggered fetal growth restriction in mice: The mediation of inactivating autophagy-lysosomal degradation system in placental ferroptosis.

Carbon black nanoparticles (CBNPs) are ubiquitous in our daily ambient environment, either resulting from tobacco combustion or constituting the core of PM. Despite the potential risk of trafficking CBNPs to the fetus, the underlying toxicity of nano-sized carbon black particles in the placenta remains unambiguous. Pregnant C57BL/6 mice received intratracheal instillation of 30 nm or 120 nm CBNPs.

Enhancing the nutritional value and caliber of silver carp surimi by adding β-carotene: Insights into the gel characteristics, protein structure, and digestive properties.

To investigate the effects of β-carotene on the gelling and digestion properties of surimi gels and the underlying molecular mechanisms, the gel properties, moisture distribution, rheological properties, secondary structure and microstructure were determined at different β-carotene concentrations (0 % ∼ 0.1 %). The results indicated that β-carotene levels from 0.

Simultaneous degradation of organoarsenic and immobilization of arsenate by an electroactive CuFeO-CNT/peroxymonosulfate platform: Insights into the distinct roles of the Cu and Fe sites.

Phenylarsonic acid (PAA) compounds, widely used in animal husbandry, pose a considerable environmental threat owing to their potential transformation into toxic inorganic arsenic species. To efficiently decontaminate PAA and adsorb secondary As(V), a hybrid CuFeO-modified carbon nanotube (CuFeO-CNT) filter was developed in this study. The hybrid CuFeO-CNT filter functioned as an effective catalyst, convective filtration medium, electrode, and adsorbent.

Ginsenoside compound K decreases presentation of citrullinated peptides by regulating autophagy-induced autoantigen activation.

Objective: Citrullinated vimentin (cVIM) triggers the immune response and is the primary autoantigen of rheumatoid arthritis (RA). Ginsenoside compound K (CK), which exerts significant anti-inflammatory effects, was the objective of this study. We aimed to investigate the role and mechanism of CK in regulating presentation of citrullinated peptides.

Enhancing colonic health with encapsulated grape seed anthocyanins: Oral capsule for Colon-targeted delivery.

Grape seed anthocyanins (GSA) offer health benefits and protect against diseases, including colitis. Its unpleasant smell and instability prevent widespread application. Antisolvent pretreatment GSA was encapsulated in chitosan-phytic acid 3D gel network.

Short-term association between ambient air pollution and childhood non-allergic rhinitis: A time-series study at a National Children's Regional Medical Center, in Hefei, China, from 2015 to 2021.

The relationship between air pollution exposure and non-allergic rhinitis (NAR) risk in children is underexplored and uncertain. Therefore, the impact of numerous air pollutants on the incidence of NAR in a Chinese pediatric population were investigated. Data on daily outpatient visits for NAR among children aged 0-18 years from 2015 to 2021 were obtained from Anhui Provincial Children's Hospital.

Cadmium exposure increases insecticide sensitivity of Sogatella furcifera (Horváth) by decrease the diversity of symbiotic bacteria.

Cadmium (Cd) is a prevalent environmental pollutant in agricultural ecosystems, particularly within paddy ecosystems, is readily absorbed by rice and enter herbivorous insects through the food chain, thereby influencing the implementation of integrated pest management strategies. However, the effect and mechanisms of Cd exposure on the sensitivity of pests in paddy to insecticides remain unclear. Therefore, this study investigated the effects of Cd exposure on the fitness, insecticide sensitivity and symbiotic bacteria of Sogatella furcifera (Horváth) (white-backed planthopper, WBPH).

Ghrelin alleviates inflammation and pyroptosis by inhibiting TNF-α /caspase-8/caspase-3/ GSDME signalling pathways in an in vitro model of high glucose induced liver injury.

Diabetic liver injury (DLI) refers to liver injury resulting from prolonged chronic hyperglycemia and represents a significant complication associated with diabetes, The specific pathogenic mechanism of DLI remains incompletely understood. Tumor necrosis factor α (TNF-α) has been demonstrated to play a crucial role in diabetic complications through intricate signalling pathways, including pyroptosis. However, it remains uncertain whether TNF-α mediates pyroptosis in DLI, we initially established an in vitro model of DLI and confirmed the presence of an inflammatory state characterized by TNF-α in DLI.

Chinese consensus report on the assessment and management of obstructive sleep apnea in patients with cardiovascular disease: 2024 edition.

As cardiovascular disease (CVD) incidence and mortality rates continue to rise in China, the importance of identifying and managing CVD risk factors grows. Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder, affecting an estimated 936 million individuals aged 30-69 worldwide, with China leading globally with about 176 million affected. Increasing research indicates a close association between OSA and the onset and progression of various CVD, significantly affecting outcomes.

TMT-Based quantitative proteomic analysis reveals age-related changes in eggshell matrix proteins and their correlation with eggshell quality in Xinyang blue-shelled laying hens.

The decline in eggshell quality with increasing hen age may be related to changes in ultrastructure and chemical composition, with matrix proteins playing key roles in these changes. However, research on blue-shelled eggs remains limited. This study investigated the effects of hen age (35, 55, 75, and 85 weeks) on the physical, mechanical, and chemical properties of eggshells in the Xinyang blue-shelled laying hens, as well as their ultrastructural and nanostructural characteristics.

Full-length transcriptome sequencing of seven tissues of GuShi chickens.

Chickens are vital economic poultry and serve as exemplary models for avian research. The incomplete reference genome of chickens and the limited availability of full-length cDNA impede the identification of alternatively spliced transcripts, thereby delaying many fundamental chicken studies. We utilized PacBio Iso-seq technology on various chicken tissues, obtaining 170,162 full-length transcripts through comprehensive transcriptome sequencing and annotation.

Occurrence, Seasonal Variation, and Health Risks of PM-bound Liquid Crystal Monomers (LCMs) in Beijing, China.

Liquid crystal monomers (LCMs) are potentially persistent, bioaccumulative, and toxic emerging pollutants. However, their occurrence in outdoor PM and related human exposure risks remain unknown. In this study, 32 composite samples were analyzed, which were prepared from daily PM samples collected throughout the year 2021 -2022 in Beijing, China.

Transposon mutagenesis identifies the sspA-sspB operon as essential for serum resistance and virulence in avian pathogenic Escherichia coli.

Avian pathogenic Escherichia coli (APEC) constitutes a significant threat to poultry health worldwide, causing colibacillosis and inflicting substantial economic losses. The ability to resist serum-mediated killing is a key virulence factor enabling APEC to circumvent the host immune system and establish systemic infection. In this study, we employed mariner-based transposon mutagenesis to generate a mutant library of APEC strain E058 and screened for mutants with reduced serum resistance.

Design and performance analysis of multi-enzyme activity-doped nanozymes assisted by machine learning.

Traditional design approaches for nanozymes typically rely on empirical methods and trial-and-error, which hampers systematic optimization of their structure and performance, thus limiting the efficiency of developing innovative nanozymes. This study leverages machine learning techniques supported by high-throughput computations to effectively design nanozymes with multi-enzyme activities and to elucidate their reaction mechanisms. Additionally, it investigates the impact of dopants on the microphysical properties of nanozymes.

The power of sound: Exploring the auditory influence on visual search efficiency.

In a dynamic visual search environment, a synchronous and meaningless auditory signal (pip) that corresponds with a change in a visual target promotes the efficiency of visual search (pop out), which is known as the pip-and-pop effect. We conducted three experiments to investigate the mechanism of the pip-and-pop effect. Using the eye movement technique, we manipulated the interval rhythm (Exp.

Network analysis of the hair-based nine hormones from four neuroendocrine systems.

Introduction: The stress response maintains the homeostasis of the body's internal environment and normal physiological activities, involving several neuroendocrine systems, such as the HPA axis, the HPG axis, the endocannabinoid system, and the melatonin system. However, studies on the intricate interactions among the four neuroendocrine systems are lacking, and it is not clear how these interactions are affected by demographic variables. The aim of this study was to investigate the network characteristics of hormonal networks comprising nine hormones from four neuroendocrine systems and how they were affected by demographic variables.

Advanced aqueous phenazine redox flow battery enhanced by selective interfacial water behavior on Co/NC modified electrode.

Although aqueous organic redox flow battery (RFBs) is a highly promising energy storage device, the redox reaction kinetics of the anode organic electrolyte material, especially for phenazine derivatives, are limited by low electrochemical activity of traditional porous carbon electrodes. Herein, Co/NC composite electrocatalyst was elaborated to significantly enhance the redox reaction kinetics of phenazine derivatives, in which Co/NC electrocatalyst could improve energy efficiency of aqueous phenazine RFBs by 43.2 % compared to pure carbon felt electrodes at current density of 100 mA/cm.