Sex Differences in Spatiotemporal Consistency and Effective Connectivity of the Precuneus in Autism Spectrum Disorder.

Autism spectrum disorder (ASD) has been reported to exhibit altered local functional consistency. However, previous studies mainly focused on male samples and explored the temporal consistency in the ASD brain ignoring the spatial consistency. In this study, FOur-dimensional Consistency of local neural Activities (FOCA) analysis was used to investigate the sex differences of local spatiotemporal consistency of spontaneous brain activity in ASD.

Effect of Qigong exercise on quality of life and cortisol in patients with cancer: a non-randomized controlled trial.

Purpose: The aim of this study was to investigate the effect of a 6-month Guolin Qigong on quality of life and serum cortisol among patients with cancer.

Methods: This study was a two-arm and non-randomized controlled trial. Forty-nine patients with cancer who were over 18 years of age and diagnosed with cancer were enrolled in this study and assigned to either the Guolin Qigong intervention group (IG, n = 26) or the usual care group (UC, n = 23) for 6 months.

Novel Perspectives Focused on the Relationship Between Herpesvirus Encephalitis and Anti-GFAP-Antibody-Positive Astrocytopathy.

Virus encephalitis (VE), recognized as one of the common kinds of central nervous system (CNS) diseases after virus infection, has a surprising correlation with autoimmune encephalitis (AE) when autoimmune antibodies emerge in cerebrospinal fluid (CSF) or serum. Herpes simplex virus and Epstein-Barr virus are the most critical agents worldwide. By molecular mimicry, herpes viruses can invade the brain directly or indirectly.

Fully Flexible Humidity Sensor with Fast Response and High Responsivity Based on rGO/MoS for Human Respiration Monitoring and Nontouch Switches.

Humidity sensors have been widely used to monitor humidity in daily life, agriculture fields, and so on. However, conventional sensors are not suitable for wearable devices because of their large dimensions and rigid substrates. Hence, we report a fast response, highly sensitive, and fully flexible humidity sensor on a PI substrate based on the composite material of reduced graphene oxide (rGO)/MoS, with a response time of 0.

Effects of Prebiotics and Probiotics on Symptoms of Depression and Anxiety in Clinically Diagnosed Samples: Systematic Review and Meta-analysis of Randomized Controlled Trials.

Context: The use of prebiotics and probiotics as a treatment for psychiatric conditions has gained interest due to their potential to modulate the gut-brain axis. This review aims to assess the effectiveness of these interventions in reducing symptoms of depression and anxiety in psychiatric populations.

Objective: The aim was to comprehensively review and appraise the effectiveness of prebiotic, probiotic, and synbiotic interventions in reducing clinical depression and anxiety symptoms.

Cognitive risk and behaviour related to the effects of mobile phone use on sleep quality: an analysis of data from Chinese college students.

This study assessed the relationships among cognitive risk, phone use behaviors, and sleep quality. We used a questionnaire, which included the Pittsburgh Sleep Quality Index (PSQI), mobile phone use behaviours, and questionnaires on mobile phone use cognitive risk to gather information from 1204 college students. T-test, chi-square test, and Wilcoxon signed rank test were applied to test differences in measurement data.

Efficacy and safety of low-dose TBI combined MAC regimen for HSCT in high-risk AML patients with active disease.

Background: The management of high-risk acute myeloid leukaemia (AML) remains challenging, highlighting the need for innovative conditioning strategies beyond current regimens.

Methods: In the present single-arm study, a FACT regimen comprised of low-dose total body irradiation (TBI) with fludarabine, cytarabine and cyclophosphamide was employed to treat cytogenetically high-risk AML patients exhibiting pre-transplant active disease. This clinical trial is registered in the Chinese Clinical Trial Registry with the registration number ChiCTR2000035111.

Action Potential Firing Patterns Regulate Dopamine Release via Voltage-Sensitive Dopamine D2 Autoreceptors in Mouse Striatum In Vivo.

Dopamine (DA) in the striatum is vital for motor and cognitive behaviors. Midbrain dopaminergic neurons generate both tonic and phasic action potential (AP) firing patterns in behavior mice. Besides AP numbers, whether and how different AP firing patterns per se modulate DA release remain largely unknown.

Direct Observation of Hybridization Between Co 3d and S 2p Electronic Orbits: Moderating Sulfur Covalency to Pre-Activate Sulfur-Redox in Lithium-Sulfur Batteries.

Lithium-sulfur batteries (LSBs) offer high energy density and environmental benefits hampered by the shuttle effect related to sluggish redox reactions of long-chain lithium polysulfides (LiPSs). However, the fashion modification of the d-band center in separators is still ineffective, wherein the mechanism understanding always relies on theoretical calculations. This study visibly probed the evolution of the Co 3d-band center during charge and discharge using advanced inverse photoemission spectroscopy/ultraviolet photoemission spectroscopy (IPES/UPS), which offers reliable evidence and are consistent well with theoretical calculations.

Revealing the heterogeneity of treatment resistance in less-defined subtype diffuse large B cell lymphoma patients by integrating programmed cell death patterns and liquid biopsy.

Precision medicine in less-defined subtype diffuse large B-cell lymphoma (DLBCL) remains a challenge due to the heterogeneous nature of the disease. Programmed cell death (PCD) pathways are crucial in the advancement of lymphoma and serve as significant prognostic markers for individuals afflicted with lymphoid cancers. To identify robust prognostic biomarkers that can guide personalized management for less-defined subtype DLBCL patients, we integrated multi-omics data derived from 339 standard R-CHOP-treated patients diagnosed with less-defined subtype DLBCL from three independent cohorts.

A tripartite transcriptional module regulates protoderm specification during embryogenesis in Arabidopsis.

Protoderm formation is a crucial step in early embryo patterning in plants, separating the precursors of the epidermis and the inner tissues. Although key regulators such as ARABIDOPSIS THALIANA MERISTEM LAYER1 (ATML1) and PROTODERMAL FACTOR2 (PDF2) have been identified in the model plant Arabidopsis thaliana, the genetic pathways controlling protoderm specification remain largely unexplored. Here, we combined genetic, cytological, and molecular approaches to investigate the regulatory mechanisms of protoderm specification in Arabidopsis thaliana.

Progress of CCL20-CCR6 in the airways: a promising new therapeutic target.

The chemokine CCL20, a small cytokine that belongs to the C-C chemokine family, interacts with its homologous receptor CCR6, which is expressed on wide range of cell types. According to current research, the CCL20-CCR6 has been established as acritical player in a diverse range of inflammatory, oncogenic, and autoimmune diseases. Within the respiratory system, CCL20-CCR6 demonstrates heightened expression in conditions such as allergic asthma, chronic airway inflammation, non-small cell lung cancer (NSCLC), chronic obstructive pulmonary disease (COPD), and other respiratory diseases, which is conducive to the inflammatory mediators recruitment and tumor microenvironment remodeling.

The role of lignin in 17β-estradiol biodegradation: insights from cellular characteristics and lipidomics.

17β-estradiol (E2) is an endocrine disruptor, and even trace concentrations (ng/L) of environmental estrogen can interfere with the endocrine system of organisms. Lignin holds promise in enhancing the microbial degradation E2. However, the mechanisms by which lignin facilitates this process remain unclear, which is crucial for understanding complex environmental biodegradation in nature.

Development of a set of indicators for the quality of chronic pain management in Chinese community-dwelling older adults: a Delphi study.

Background: Standardized and systematic quality assessments of chronic pain management, particularly among older adult populations, are lacking in resource-limited community settings. A specific set of indicators to evaluate the quality of chronic pain management in this population has yet to be developed. Therefore, the present study constructed a set of indicators to assess the quality of chronic pain management in Chinese community-dwelling older adults, providing a standardized reference and guidance for community health centers to manage chronic pain in this population.

Leadless pacemaker implantation after delayed atrial lead perforation and battery depletion: a case report.

Background: Delayed lead perforation is a rare complication of cardiac implantable electronic device (CIED). Clinical presentations range from completely asymptomatic to pericardial tamponade. Surgical lead extraction is recommended and transvenous lead extraction (TLE) with surgical backup is an alternative method.

Genome-wide association study of sucrose content in vegetable soybean.

Background: Vegetable soybean is an important legume vegetable. High sucrose content is a significant quality characteristic of vegetable soybean that influences consumers' taste. However, the genetic basis of sucrose content in vegetable soybean is currently unclear.

Association Between Treatment-Related Adverse Event Trajectory and Prognosis in Esophageal Cancer Receiving Neoadjuvant Immunochemotherapy.

Background: Immunochemotherapy is inevitably accompanied with treatment-related adverse events (TRAEs). However, TRAEs are typically assessed at a single time point, overlooking the complexity of TRAE trajectories over time. This study aimed to characterize TRAE trajectories during multi-cycle neoadjuvant immunochemotherapy (nICT) and identify potential prognostic factors for patients with esophageal squamous cell carcinoma (ESCC).

A Gaussian convolutional optimization algorithm with tent chaotic mapping.

To solve the problems of the traditional convolution optimization algorithm (COA), which are its slow convergence speed and likelihood of falling into local optima, a Gaussian mutation convolution optimization algorithm based on tent chaotic mapping (TCOA) is proposed in this article. First, the tent chaotic strategy is employed for the initialization of individual positions to ensure a uniform distribution of the population across a feasible search space. Subsequently, a Gaussian convolution kernel is used for an extensive depth search within the search space to mitigate the likelihood of any individuals converging to a local optimum.

Smoking-associated electrocardiographic abnormalities predict cardiovascular mortality.

Background -Smoking is associated with arrhythmia and sudden cardiac death, but the biological mechanisms remain unclear. In electrocardiogram (ECG) recordings abnormal durations of ventricular repolarization (QT interval), atrial depolarization (P wave), and atrioventricular depolarization (PR interval and segment), predict cardiac arrhythmia and mortality. Previous analyses of the National Health and Nutrition Examination Survey (NHANES) database for associations between smoking and ECG abnormalities were incomplete.

Spatio-temporal evolution and obstacle diagnosis of human settlements based on the "production-living-ecological" functions.

Sustainable development is a hot topic of global concern and sustainable human settlements (HS) are crucial to people's happiness. Thus, strengthening the construction of HS will help enrich human settlements geography with theories of HS interactions, clarify the existing problems of the Chengdu-Chongqing urban agglomeration (CC), promote the harmonization of the human-land relationship, and realize the SDGs. The results were as follows.

Secretory breast carcinoma: a multicenter clinicopathologic study of 80 cases with emphasis on prognostic analysis and chemotherapy benefit.

Purpose: To investigate clinicopathologic characteristics and prognosis in secretory breast carcinoma (SBC) and to determine chemotherapy benefits stratified by different subgroups.

Methods: SBCs and triple-negative invasive ductal carcinoma patients (TN-IDCs) were enrolled from three cancer centers between January 2011 and December 2020. SBCs were further divided into two subgroups: those with triple negativity (TN-SBCs) and those without (non-TN-SBCs).

Enhancing active fire detection in Sentinel 2 imagery using GLCM texture features in random forest models.

The array of wildfire activities instigated by human endeavors has emerged as a significant source of atmospheric pollution, posing considerable risks to both public health and property safety. This study harnesses Sentinel-2 satellite data, employing a variety of methods including spectral index methods, thresholding, and the Random Forest (RF) model for active fire spot detection. The research encompasses a wide range of land cover types across various Chinese regions.

Association of daily physical activity with hypertension, depressive symptoms, loneliness, and poor sleep quality in aged 60-79 older adults.

This study aimed to assess its relationship between physical activity with health-related indicators in older population of the China. Cross-sectional data of 1,327 individuals aged 60-79 years were analyzed. Based on the Fifth National Physical Fitness Monitoring Program, depressive symptom and loneliness were measured using the Patient Health Questionnaire-9 and Emotional versus Social Loneliness Scales, respectively.

Acute effects of different physical activity on executive function and regulation role of beta oscillation in sedentary youth frontal region.

Chronic sedentary behavior can have a negative impact on the executive function (EF) of young people. While physical activity (PA) has been shown to improve this phenomenon, the effects of different types of PA on EF vary. In this study, we compared the effects of moderate-intensity continuous training (MICT) (60-70% HRmax, 30 min), body weight training (BWT) (2 sets tabata, 20 min), and mind-body exercise (MBE) (2 sets Yang style shadowboxing, 20 min) on EF in 59 sedentary youth (n = 59, age = 20.