Publications by authors named "Gan-Zhong Wei"
Background: Mutations in genes encoding tumor necrosis factor (TNF)-α and interleukin (IL)-6 were previously shown to affect mortality. Single nucleotide polymorphisms (SNPs) in the functional promoter regions of TNF-α (G308A) and IL-6 (G174C) are among the most widely studied.
Objectives: To determine whether TNF-α G308A and IL-6 G174C SNPs confer susceptibility to longevity, we performed a meta-analysis to comprehensively estimate the association between these SNPs and longevity in long-lived individuals (LLI, aged ≥ 80 years).
Background: Genetic mutations in the paraoxonase 1 (PON1) encoding gene have been considered to affect mortality and of these the functional promoter region polymorphisms Q192R and L55M are among the most widely studied.
Objective: The aim of this study was to determine whether the Q192R and L55M polymorphisms of PON1 can increase susceptibility to longevity. A meta-analysis was performed to obtain a comprehensive estimation of the association between Q192R and L55M and longevity in long-lived individuals (LLIs) aged 80 years or more.
Article Synopsis
- Nematophagous fungi, like Clonostachys rosea, are being studied as biological control agents against parasitic nematodes, using subtilisin-like serine proteases to infect them.
- The expression of the prC gene, crucial for the fungi's virulence, is influenced by nitrogen sources; preferred sources like glutamine and ammonia downregulate prC at the transcriptional level, while nematode cuticle upregulates it post-transcriptionally.
- High levels of ammonia could hinder the effectiveness of these fungi in controlling nematodes in fields with excess fertilizer, as it suppresses prC expression and, consequently, the fungi's virulence.