Publications by authors named "Gan-Hong Lin"

Article Synopsis
  • * A study involving whole-exome sequencing of 11 Taiwanese patients with severe AIS identified over 200 potential rare genetic variants, but most were unique to single individuals.
  • * Key genes linked to AIS were pinpointed, with one pathogenic variant shared among 35% of patients, indicating these genes play critical roles in the condition's development.
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Article Synopsis
  • Overweight and obesity increase disease risks, and their prevalence has sharply grown in Taiwan, prompting a study on genetic factors related to body composition.
  • A genome-wide association study analyzed data from over 21,000 individuals, identifying 13 significant genetic loci linked to traits such as BMI, body fat percentage, waist circumference, and waist-hip ratio.
  • Findings revealed known and new genetic factors influencing adiposity, with a specific gene (RALGAPA1) linked to high BMI, and highlighted the role of neural pathways, indicating different genetic influences on various types of body fat distribution in the Taiwanese population.
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Osteoporosis is characterized by decreased bone mineral density and increased risk of fracture. Raloxifene is one of the treatments of osteoporosis. However, the responses were variable among patients.

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