The Putative Effects of Neoadjuvant Chemotherapy on the Immune System of Advanced Epithelial Ovarian Carcinoma.

The epithelial ovarian carcinoma (EOC) is one of leading causes of cancer-related mortality in females. For some patients, complete resection cannot be achieved, thus neoadjuvant chemotherapy (NACT) following interval debulking surgery (IDS) could be an alternative choice. In general-held belief, cytotoxic chemotherapy is assumed to be immunosuppressive, because of its toxicity to dividing cells in the bone marrow and peripheral lymphoid tissues.

Contrasting effects of nitrogen enrichment on ecosystem temporal stability before and after nitrogen saturation in a subalpine grassland.

Increased atmospheric nitrogen deposition generally increases plant biomass production until reaching soil N saturation, which could increase the uncertainty of changes in ecosystem temporal stability and their mechanisms. Yet, the response of ecosystem stability to N enrichment and their underlying mechanisms are uncertain, especially when N saturation reached. Here, we conducted a multi-level N addition (0, 2, 5, 10, 15, 25, and 50 g N m year; high added rates reached N saturation) experiment from 2018 to 2022 to estimate the effect of simulated N deposition on ecosystem biomass stability in a subalpine grassland located on the Qilian mountain of north-eastern Tibetan Plateau.

[Effects of Short-Term Nitrogen and Phosphorus Addition on Soil Respiration Components in a Subalpine Grassland of Qilian Mountains].

In order to investigate the effects of short-term nitrogen and phosphorus addition on soil respiration and its components in a subalpine grassland located on the Qilian Mountains, a random block design of nitrogen[10 g·(m·a), N], phosphorus[5 g·(m·a), P], nitrogen and phosphorus addition[10 g·(m·a)N and 5 g·(m·a)P, NP], the control (CK), and complete control (CK') was conducted from June to August 2019, and total soil respiration and its component respiration rates were measured. The results showed that nitrogen addition reduced soil total respiration and heterotrophic respiration rates at a lower rate than P addition[-16.71% vs.

Metabolomic profiling identifies hair as a robust biological sample for identifying women with cervical cancer.

Metabolomics serves as a useful tool for identifying biomarkers of disease and uncovering pathogenic mechanisms. However, most metabolomic studies use biological fluids such as blood and urine as biospecimens, which could be dramatically influenced by daily activities and dietary variation, resulting in measurement fluctuations. In contrast, hair may serve as a robust source of stable longitudinal metabolite information.

Nitrogen effects on grassland biomass production and biodiversity are stronger than those of phosphorus.

Human-induced nitrogen (N) and phosphorus (P) enrichment have profound effects on grassland net primary production (NPP) and species richness. However, a comprehensive understanding of the relative contribution of N vs. P addition and their interaction on grassland NPP increase and species loss remains elusive.

Identification of a novel circ_0018289/miR-183-5p/TMED5 regulatory network in cervical cancer development.

Background: Circular RNAs (circRNAs) are increasingly implicated in regulating human carcinogenesis. Previous work showed the oncogenic activity of circ_0018289 in cervical cancer. However, the molecular basis underlying the modulation of circ_0018289 in cervical carcinogenesis is still not fully understood.

Two Zn(II)-based Coordination Polymers: Fe Ion and Prevention Activity Detection On Postpartum Hemorrhage By Regulating Anticoagulant Factor Activity.

Two new Zn(II)-based coordination polymers {[Zn(L)(HO)]∙(HO)} (1, HL = 4-(tetrazol-5-yl)phenyl-4,2':6',4″-terpyridine) and [ZnCl(L)HO] (2, HL = 4-([2,2':6',2″'-terpyridin]-4'-yl)benzoic acid) have been successfully prepared using two similar organic ligands with distinct donor groups under similar reaction conditions. The distinct structural features and donor atoms make the two complexes show different water stability, and the complex 1 with good water stability, which can be utilized as the sensor for Fe ion detection in water. The value of Stern-Volmer quenching constant of 1 to the Fe is 5.

CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a.

Background: Circular RNA (circRNA) has been proven to play a significant role in multiple types of cancer. However, the expression and role of circRNAs in epithelial ovarian cancer (EOC) remains elusive.

Methods: CircRNA and mRNA expression profiles of EOC were screened with sequencing analysis.

MicroRNA-19b-3p promotes cell proliferation and osteogenic differentiation of BMSCs by interacting with lncRNA H19.

Background: To investigated the role of miR-19b-3p in regulating bone marrow mesenchymal stem cell (BMSC) proliferation and osteoblast differentiation.

Methods: The expression of miR-19b-3p and lncRNA H19 were measured in postmenopausal osteoporosis patients and BMP-22 induced BMSCs using qRT-PCR. MiR-19b-3p mimic or inhibitor was transfected into BMP-2 induced BMSCs.

ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2.

Background: ALKBH5 regulated the malignant behavior of breast cancer and glioblastoma. However, the expression and function of ALKBH5 in epithelial ovarian cancer have not yet been determined. In the present study, we investigated the expression and function of ALKBH5 in epithelial ovarian cancer with respect to its potential role in the tumorigenesis of the disease as well as an early diagnostic marker.

Linc02527 promoted autophagy in Intrahepatic cholestasis of pregnancy.

LncRNA plays a crucial role in human disease. However, the expression and function of LncRNA in ICP(Intrahepatic cholestasis of pregnancy) is still not fully elucidated. In this study, we found Linc02527 was increased expression in placenta and serum of ICP patients.

[Tinnitus assessment by THI and VAS in patients with sudden sensorineural hearing loss].

Objective: To verify the relationship between THI and VAS scores in patients with sudden hearing loss and tinnitus in a prospective study.

Method: Forty-four patients classified their tinnitus according to VAS and THI before and after treatment, and both scores were compared through the Pearson's correlation coefficient test and Nonparametric tests.

Result: There was a correlation between VAS and THI scores in patients with sudden hearing loss and tinnitus.

The effects of hyaluronic acid vaginal gel on the vaginal epithelium of ovariectomized rats.

Objective: Hyaluronic acid is one of the best materials of water retention which can be used in vaginal atrophy. This study is to evaluate the role and mechanism of the hyaluronic acid vaginal gel (Hyalofemme) in the vaginal epithelium of ovariectomized rats.

Materials And Methods: Sixty SD rats were randomly divided into control group (Sham ovariectomy, Sham-OVX), tendency group (ovariectomy, OVX), and experiment group (ovariectomy+Hyalofemme, OVX+Hyalofemme).

Provincial maternal mortality surveillance systems in China.

Background: Provincial maternal mortality surveillance systems (PMMSS) have been set up in nearly all the provinces in China to monitor local maternal mortality and provide the evidence for maternal health interventions suited to local conditions. However, till now little is known outside of China about the characteristics of PMMSS.

Methods: A systematic review of the literature contained in PubMed and China Academic Journal Network Publishing database was carried out.

Low TWEAK expression is correlated to the progression of squamous cervical carcinoma.

Objective: To investigate the correlation of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its specific receptor fibroblast growth factor-inducible immediate-early response protein 14 (Fn14) to cervical carcinogenesis by examining TWEAK/Fn14 expression levels or locations in different cervical tissues and cells.

Methods: TWEAK/Fn14 mRNA expressions were detected by quantitative real-time PCR in total of 120 cervical samples including normal, precancerous and cancerous tissues, while protein expressions were detected by immunofluorescent staining and western blot in both tissues and cell lines. Correlation between TWEAK expression levels to cancer progression and clinicopathologic features was statistically analyzed.

Association of inhibitor of differentiation 1 expression with human papillomaviruses infections in cervical carcinoma.

Background: Our recent study has shown that inhibitor of differentiation 1 (Id-1) is overexpressed in cervical carcinoma. However, the relationship between Id-1 expression and human papillomavirus (HPV) infection has not been elucidated. In this study, we investigate the association of Id-1 protein expression and HPV infection in cervical carcinoma tissues.

[Correlation and path analysis of artemisininum content and related factor on Artemisiae annie in Three Gorges reservoir area].

Objective: Study on the correlation and path analysis of artemisininum comtent and related factor on Artemisiae annie. In order to obtain high artemisininum content Artemisiae annie.

Methods: On the natural condition, choose 36 area where Artemisiae annie growth in three gorges reservoir area.

High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma.

Purposes: Uterine cervical carcinosarcoma (CS) is very rare. To date, only 40 cases have been reported. It seems to have a more aggressive clinical behavior than does cervical squamous cell carcinoma (SCC).

Association of an interleukin-16 gene polymorphism with the risk and pain phenotype of endometriosis.

Interleukin-16 (IL-16), a proinflammatory cytokine, plays a pivotal role in inflammatory diseases as well as in the pathogenesis of endometriosis. The aim of this study was to evaluate the association of IL-16 gene polymorphisms with the risk and clinical phenotypes of endometriosis in Chinese women. We analyzed rs4778889 T/C, rs11556218 T/G polymorphisms of the IL-16 gene in 230 patients with endometriosis and 203 controls in a Chinese population, using a polymerase chain reaction-high resolution melting analysis strategy and DNA sequencing methods.

[Expressions of SHP and CYP7A1 in pregnant rats with intrahepatic cholestasis].

Objective: To investigate the expressions of small heterodimer partner (SHP) and target gene cholesterol-7-hydroxylase (CYP7A1) in livers of rats with intrahepatic cholestasis of pregnancy (ICP), and to study the mechanism of ICP.

Methods: Thirty SD rats (pregnant for 15 days) were equally and randomly divided into two groups: an estradiol benzoate (EB) group and a normal saline (NS) group. Two ml blood was drawn from each rat before and on the 5th day after medicine administration to measure the levels of ALT, AST, ALP, TBA, TBIL, and DBIL.