Publications by authors named "Gan Wei Zien"
Article Synopsis
- Aging leads to molecular damage that disrupts normal body functions, particularly affecting the NGR amino acid sequence, which transforms into the harmful isoDGR, promoting chronic inflammation and cardiovascular issues.
- Anti-isoDGR immunotherapy has been shown to extend the lifespan of Pcmt1 mice by reducing isoDGR levels in tissues and lowering inflammation, thereby improving cognitive and motor functions.
- This study suggests that targeting damaged proteins associated with aging through immunotherapy could be a promising approach for treating various degenerative diseases in humans.
Diabetes mellitus (DM) is a group of metabolic diseases related to the dysfunction of insulin, causing hyperglycaemia and life-threatening complications. Current early screening and diagnostic tests for DM are based on changes in glucose levels and autoantibody detection. This review evaluates recent studies on biomarker candidates in diagnosing type 1, type 2 and gestational DM based on omics classification, whilst highlighting the relationship of these biomarkers with the development of diabetes, diagnostic accuracy, challenges and future prospects.
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