Human-Centric Spatial Cognition Detecting System Based on Drivers' Electroencephalogram Signals for Autonomous Driving.

Existing autonomous driving systems face challenges in accurately capturing drivers' cognitive states, often resulting in decisions misaligned with drivers' intentions. To address this limitation, this study introduces a pioneering human-centric spatial cognition detecting system based on drivers' electroencephalogram (EEG) signals. Unlike conventional EEG-based systems that focus on intention recognition or hazard perception, the proposed system can further extract drivers' spatial cognition across two dimensions: relative distance and relative orientation.

Identification of tea resources with high accumulation of 1-O-galloyl-6-O-luteoyl-α-D-glucose and comprehensive dissection of its variation.

Tea is a widely consumed beverage worldwide due to its rich secondary metabolites. Gallotanin: 1-O-galloyl-6-O-luteoyl-α-D-glucose (GLAG) has strong antioxidant activity and good resistance to a wide range of bacteria and malaria. Despite its potential, there have been few reports on GLAG in plants.

Discovery of potent antiosteoporotic cyclic depsipeptides with an unusual nitrile hydroxy acid from Microascus croci.

Two cyclic octadepsipeptides, microascusins A and B (1 and 2), were identified from the marine sponge-associated Microascus croci IMB19-064 co-cultivated with Escherichia coli. Their structures and conformations in solution were determined by comprehensive spectroscopic data analysis. The absolute configurations of amino and hydroxy acids were determined by the advanced Marfey's and O-Marfey's methods, respectively, as well as chiral-phase HPLC analysis.

Identification of clinicopathological-specific driver gene and genetic subtyping of colorectal cancer.

This study analyzed targeted sequencing data from 6530 tissue samples from patients with metastatic Chinese colorectal cancer (CRC) to identify low mutation frequency and subgroup-specific driver genes, using three algorithms for overall CRC as well as across different clinicopathological subgroups. We analyzed 425 cancer-related genes, identifying 101 potential driver genes, including 36 novel to CRC. Notably, some genes demonstrated subgroup specificity; for instance, ERBB4 was found as a male-specific driver gene and mutations of ERBB4 only influenced the prognosis of male patients with CRC.

Improving the Electrochemical and Electrochromic Properties of Copolymerized 3,4-Ethylenedioxythiophene with Pyrene.

Pyrene (Pr) was used to improve the electrochemical and electrochromic properties of polythiophene copolymerized with 3,4-ethylenedioxythiophene (EDOT). The corresponding product, poly(3,4-ethylenedioxythiophene-co-Pyrene) (P(EDOT-co-Pr)), was successfully synthesized by electrochemical polymerization with different monomer concentrations in propylene carbonate solution containing 0.1 M lithium perchlorate (LiClO/PC (0.

Experimental research on the structural optimization of grouting holes in circular and rectangular pipe sections for trenchless pipe jacking.

In trenchless pipe jacking engineering practice, the formation of high-quality slurry jacket on the outer wall of pipe section is the key to effectively reducing the pipe-soil frictional resistance, improving the construction efficiency, reducing the construction risk and ensuring the construction safety. Herein, the multifunctional experimental apparatus for the pipe-soil frictional resistance testing is improved to ensure the smooth implementation of the subsequent experimental research. The influences of the structural parameters of grouting holes in circular and rectangular pipe sections on the pipe-soil frictional resistance and the states of slurry jackets around the various pipe sections are investigated respectively based on orthogonal experiment.

Advances in research on the impact and mechanisms of pathogenic microorganism infections on pyroptosis.

Pyroptosis, also known as inflammatory necrosis, is a form of programmed cell death characterized by the activation of gasdermin proteins, leading to the formation of pores in the cell membrane, continuous cell swelling, and eventual membrane rupture. This process results in the release of intracellular contents, including pro-inflammatory cytokines like IL-1β and IL-18, which subsequently trigger a robust inflammatory response. This process is a crucial component of the body's innate immune response and plays a significant role in combating infections.

Metabolome and transcriptome profiling reveal tRNA-derived small RNAs regulated glutathione metabolism in intrauterine growth-restricted pigs.

Intrauterine growth retardation (IUGR) has become a difficult problem in animal husbandry and is often accompanied by the occurrence of metabolic syndrome. tRNA-derived small RNAs (tsRNAs) are a novel class of regulatory small noncoding RNAs. However, the involvement of tsRNA in regulating the mechanism of IUGR remains unclear.

Effectiveness of digital modified behavioral activation treatment program for rural older adults with depressive symptoms in Western Hunan: study protocol for a multi-center randomized controlled trial.

Background: Rural older adults experience a high burden of depressive symptoms and significant barriers to accessing mental health services. The Modified Behavioral Activation Treatment (MBAT) has been verified to be effective among rural older adults in China. Due to its structured format and skill-based learning, it is well suited for digital-based delivery.

Protective effects of cannabinoid receptor 2 on annulus fibrosus degeneration by upregulating autophagy via AKT-mTOR-p70S6K signal pathway.

As an important pathological process, annulus fibrosus (AF) degeneration contributes greatly to intervertebral disc degeneration (IVDD). Moreover, extracellular matrix (ECM) degradation and AF cell (AFC) autophagy are of utmost importance. The involvement of cannabinoid receptor type 2 (CB2) in the pathological mechanisms underlying different diseases has been demonstrated dueto its capacity toregulateautophagy.

Metabolic targeting of regulatory T cells in oral squamous cell carcinoma: new horizons in immunotherapy.

Oral squamous cell carcinoma (OSCC) is a prevalent oral malignancy, which poses significant health risks with a high mortality rate. Regulatory T cells (Tregs), characterized by their immunosuppressive capabilities, are intricately linked to OSCC progression and patient outcomes. The metabolic reprogramming of Tregs within the OSCC tumor microenvironment (TME) underpins their function, with key pathways such as the tryptophan-kynurenine-aryl hydrocarbon receptor, PI3K-Akt-mTOR and nucleotide metabolism significantly contributing to their suppressive activities.

Coronary artery segmentation framework based on three types of U-Net and voting ensembles.

Coronary artery (CA) segmentation is critical for enabling disease diagnosis. However, the structural complexity and extensive branching of CAs may cause the segmentation outcomes of existing methods to exhibit discontinuities and considerable pseudo-CA regions. Therefore, we propose a voting-based ensemble segmentation framework based on three U-Net types to capture CA structural features from global and local perspectives.

Landsat-Derived Forel-Ule Index in the Three Gorges Reservoir over the Past Decade: Distribution, Trend, and Driver.

Water color is an essential indicator of water quality assessment, and thus water color remote sensing has become a common method in large-scale water quality monitoring. The satellite-derived Forel-Ule index (FUI) can actually reflect the comprehensive water color characterization on a large scale; however, the spatial distribution and temporal trends in water color and their drivers remain prevalently elusive. Using the Google Earth Engine platform, this study conducts the Landsat-derived FUI to track the complicated water color dynamics in a large reservoir, i.

Optimization of Cl and heavy metal removal during heat treatment of municipal solid waste incineration fly ash and municipal sludge after co-washing.

Heat treatment, known for its detoxification and volume reduction characteristics, is a promising technology for the management of municipal solid waste incineration fly ash (MFA) and municipal sludge (MS). This paper uses the solid residue from MFA and MS after co-washing as the raw material to study the melting properties, phase transformations, changes in Cl content, heavy metal removal efficiency, and leaching toxicity. The results indicated that co-processing of MFA and MS can effectively reduce the melting temperature.

Identification of host factors for livestock and poultry viruses: genome-wide screening technology based on the CRISPR system.

Genome-wide CRISPR library screening technology is a gene function research tool developed based on the CRISPR/Cas9 gene-editing system. The clustered regularly interspaced short palindromic repeats/CRISPR-associated genes (CRISPR/Cas) system, considered the third generation of gene editing after zinc finger nucleases (ZFN) and transcription activator-like effector nucleases (TALEN), is widely used for screening various viral host factors. CRISPR libraries are classified into three main categories based on the different functions of Cas9 enzymes: CRISPR knockout (CRISPR KO) library screening, CRISPR transcriptional activation (CRISPRa) library screening, and CRISPR transcriptional interference (CRISPRi) library screening.

Adsorption and catalytic reduction of hexavalent chromium based on nanomaterials: A review on metal, metallic oxide, metallic sulfide and carbon-based catalyst.

Chromium (Cr) is widely recognized as a significant environmental contaminant and a major contributor to global pollution. As a result, there is a strong emphasis on developing effective methods for the removal and reduction of Cr(VI). This review examines various applications of nanomaterial catalysts, including metallic oxides, metals, metallic sulfides, and carbon-based materials.

Improving the Mechanical Properties and Microstructure of 12 mol% Ceria-Stabilized Tetragonal Zirconia Polycrystal Ceramics with Low-Content NdO.

In this study, 12 mol% ceria-stabilized tetragonal zirconia polycrystal ceramics with xNdO (where x equals 0, 0.1, 0.2, 0.

Genomic analysis of global Mycobacterium abscessus isolates reveals ongoing evolution of drug-resistance-associated genes.

Mycobacterium abscessus (MAB) is intrinsically resistant to many antibiotics, but the evolution of acquired drug resistance is poorly understood. We analyzed published genomes of 5,617 clinical MAB isolates from 20 countries and searched for signals of ongoing evolution in 35 drug-resistance-associated genes. Of these, we found 14 genes were subject to positive selection and identified novel mutational sites under selection.