Publications by authors named "Gan Gao"

Background: Moyamoya disease (MMD) and moyamoya syndrome (MMS) are rare cerebrovascular conditions with unclear distinctions in clinical presentation and prognosis.

Aim: This study assessed potential differences between MMD and MMS patients using real-world data on clinical manifestations, surgical outcomes, and stroke risk factors.

Methods: This multicenter, retrospective cohort study examined patients with MMD or MMS treated at three tertiary academic hospitals in China, with a mean follow-up of 11.

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  • This study looked at how two diseases, Systemic Lupus Erythematosus (SLE) and moyamoya disease (MMD), might be related through certain genes and immune cells.!
  • Researchers used a variety of data analysis techniques to find common genes between SLE and MMD, discovering some important ones that could help understand both diseases.!
  • They found that specific immune cells, especially T cells and monocytes, are especially active in both diseases, suggesting they play an important role in how SLE and MMD might be linked.!
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  • Moyamoya disease (MMD) affects blood vessels in the brain and progresses faster in children than adults, prompting this study to explore age-related differences through proteomic and metabolomic profiling.
  • Six children and six adults with MMD, alongside healthy controls, underwent detailed blood analysis to identify differences in proteins and metabolites using advanced techniques.
  • Results showed significant variations between pediatric and adult MMD patients, highlighting key pathways related to immunity and inflammation and emphasizing the importance of vitamin digestion in the pediatric form of the disease.
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Objective: This study aimed to evaluate the safety and efficacy of skull-femoral traction followed by osteotomy correction in patients with severe spinal scoliosis and split cord malformation.

Methods: We retrospectively analyzed ten cases of severe spinal scoliosis with Pang I type split cord malformation treated between August 2012 and August 2023. Patients underwent skull-femoral traction prior to osteotomy correction.

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The liver is vitally metabolic for a multitude of biochemical reactions. Consequently, it generates many free radicals and reactive oxygen species, rendering it more susceptible to oxidative stress-induced damage. Oxidative stress represents a pivotal factor in the pathogenesis of liver diseases.

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Objective: To investigate factors influencing the long-term prognosis of patients with sacral Tarlov syndrome after nerve root cuff reconstruction.

Methods: A total of 42 patients with sacral Tarlov cysts who underwent nerve root cuff reconstruction at the First Medical Center of the Chinese PLA General Hospital between December 2015 and December 2021 were retrospectively reviewed. All cases were confirmed using magnetic resonance imaging and pathology.

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Human tissue, which is inherently three-dimensional (3D), is traditionally examined through standard-of-care histopathology as limited two-dimensional (2D) cross-sections that can insufficiently represent the tissue due to sampling bias. To holistically characterize histomorphology, 3D imaging modalities have been developed, but clinical translation is hampered by complex manual evaluation and lack of computational platforms to distill clinical insights from large, high-resolution datasets. We present TriPath, a deep-learning platform for processing tissue volumes and efficiently predicting clinical outcomes based on 3D morphological features.

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Objective: To conduct a meta-analysis and a bioinformatics analysis to assess the relationship between gene polymorphism and pan-cancer risk.

Methods: PubMed, EMBASE, and Web of Science were conducted to literature searches. The heterogeneity test was used in five genetic models.

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  • - The study investigates the role of the immune system, specifically complements and immunoglobulin levels, in the progression of moyamoya disease (MMD) by comparing serum samples from 84 MMD patients and 70 healthy individuals.
  • - Results indicate that MMD patients have lower serum levels of complement C3, particularly those in late-stage disease, and identified age, diastolic blood pressure, and complement C3 as significant factors associated with the progression of vasculopathy.
  • - The findings suggest that complement C3 levels could be linked to the advancement of MMD, highlighting its potential role in the disease's development and progression.
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Background: Cell division cycle protein 45 (CDC45) has been demonstrated to play vital roles in the progression of various malignancies. However, the clinical significance of CDC45 in gastric cancer (GC) remains unreported.

Method: In this study, we employed the TCGA database and the TCGA & GTEx dataset to compare the mRNA expression levels of CDC45 between gastric cancer tissues and adjacent or normal tissues ( < 0.

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Purpose: The aim of this study was to evaluate the role of a novel total meniscal implant in promoting meniscal regeneration and protecting articular cartilage in a rabbit model for 3 and 6 months.

Methods: Thirty-six New Zealand rabbits were selected and divided into poly(ɛ-caprolactone) (PG-Pg) scaffold group, meniscectomy group and sham group. In this study, it was investigated whether PG-Pg scaffold can prevent articular cartilage degeneration and promote tissue degeneration, and its mechanical properties at 3 and 6 months after surgery were also explored.

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  • - The study explores the effectiveness of combining gamma knife and phosphorus-32 brachytherapy for treating residual and recurrent craniopharyngioma, aiming to improve patient outcomes.
  • - Retrospective analysis of 97 patients revealed high tumor control rates of 49.5% for complete control and 87.6% for adequate control, with 55.1% experiencing visual improvements and a 15.5% morbidity rate.
  • - Findings suggest this treatment combination is a strong, minimally invasive option for management, potentially making it a preferred strategy for certain patients with craniopharyngioma.
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The detection of surface defects on metal products during the production process is crucial for ensuring high-quality products. These defects also lead to significant losses in the high-tech industry. To address the issues of slow detection speed and low accuracy in traditional metal surface defect detection, an improved algorithm based on the YOLOv7-tiny model is proposed.

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Background: To explore the risk factors for preoperative massive cerebral infarction (MCI) in pediatric patients with moyamoya disease (MMD).

Methods: Pediatric patients with MMD treated between 2017 and 2022 were enrolled. Logistic regression analysis was performed to identify risk factors for MCI among the patients, and a nomogram was constructed to identify potential predictors of MCI.

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Recent advances in 3D pathology offer the ability to image orders of magnitude more tissue than conventional pathology methods while also providing a volumetric context that is not achievable with 2D tissue sections, and all without requiring destructive tissue sectioning. Generating high-quality 3D pathology datasets on a consistent basis, however, is not trivial and requires careful attention to a series of details during tissue preparation, imaging and initial data processing, as well as iterative optimization of the entire process. Here, we provide an end-to-end procedure covering all aspects of a 3D pathology workflow (using light-sheet microscopy as an illustrative imaging platform) with sufficient detail to perform well-controlled preclinical and clinical studies.

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  • Intracranial vessel wall enhancement (VWE) on high-resolution MRI is linked to worse outcomes in patients with moyamoya disease (MMD), prompting a study to identify risk factors for VWE.
  • *The study involved 283 MMD patients, identifying 84 with VWE and finding risk factors such as the RNF213 gene variant, hyperhomocysteinaemia, and smoking history leading to higher incidences of cerebrovascular events.
  • *Ultimately, the RNF213 p.R4810K variant is a significant predictor of VWE and poor prognosis, highlighting the importance of these risk factors in clinical assessments for MMD.*
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Lysosomes is a well-recognized oncogenic driver and chemoresistance across variable cancer types, and has been associated with tumor invasiveness, metastasis, and poor prognosis. However, the significance of lysosomes in hepatocellular carcinoma (HCC) is not well understood. Lysosomes-related genes (LRGs) were downloaded from Genome Enrichment Analysis (GSEA) databases.

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Background: Although vaccinations and antiviral drugs are widely used in the clinical treatment worldwide, there is little investigation on the clinical outcomes and effectiveness of oral Azvudine tablets (FNC) treatment in COVID-19 hospitalized patients. The previous data showed Azvudine treatment was closely related to reduced virus shedding time, but the potential role of Azvudine on inflammatory response is scarce. Thus, this study is to investigate inflammatory predictors and effectiveness of oral Azvudine tablets treatment in COVID-19 hospitalized patients.

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A miniature optical-sectioning fluorescence microscope with high sensitivity and resolution would enable non-invasive and real-time tissue inspection, with potential use cases including early disease detection and intraoperative guidance. Previously, we developed a miniature MEMS-based dual-axis confocal (DAC) microscope that enabled video-rate optically sectioned microscopy of human tissues. However, the device's clinical utility was limited due to a small field of view, a non-adjustable working distance, and a lack of a sterilization strategy.

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Fowl adenovirus-induced hepatitis-pericardial effusion syndrome outbreaks have been increasingly reported in China since 2015, resulting in substantial economic losses to the poultry industry. The genetic diversity of indigenous chicken results in different immune traits, affecting the evolution of these viruses. Although the molecular epidemiology of fowl adenovirus serotype 4 (FAdV-4) has been well studied in commercial broiler and layer chickens, the prevalence and genetic characteristics of FAdV-4 in indigenous chickens remain largely unknown.

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