Clinical, pharmacology and in vivo studies of QingDai (indigo naturalis) promotes mucosal healing and symptom improvement in ulcerative colitis by regulating the AHR-Th17/Treg pathway.

Qingdai (QD), derived from various plant sources, is commonly used in traditional Chinese medicine for ulcerative colitis (UC) treatment. However, the clinical efficacy and mechanisms of orally administered QD remain unclear. This study aims to evaluate QD's efficacy in UC treatment and uncover its active components and mechanisms.

Microplastics and biochar interactively affect nitrous oxide emissions from tobacco planting soil.

Biochar application to amend acidified tobacco-soils can enhance tobacco quality and reduce nitrous oxide (NO) emissions. Microplastics from agricultural mulch are commonly found in cash-crop farmland soils and, together with biochar, affect soil NO emissions. In this study, we applied three types of microplastics (polyethylene, PE; polylactic acid, PLA; polybutylene adipate terephthalate, PBAT) and rice biochar alone or in combination to acidified tobacco planting soil in central China to investigate their effects on soil NO emissions, soil chemical properties, nitrogen-cycle-related functional genes, and microbial functional diversity during a 35-day laboratory incubation period.

Hesperidin promotes gastric motility in rats with functional dyspepsia by regulating Drp1-mediated ICC mitophagy.

Hesperidin is one of the main active ingredients of (Rutaceae) and tangerine peel, which have anti-inflammatory and antioxidant effects. In previous study, we found that gastric motility disorder in functional dyspepsia (FD) rats accompanied by excessive autophagy/mitochondrial swelling and even vacuolization in the interstitial cells of cajal (ICC), but the exact mechanism has not yet been investigated. Therefore, we used different doses of hesperidin (50 mg/kg, 100 mg/kg, and 200 mg/kg) to intervene in FD rats, and found that medium doses of hesperidin (100 mg/kg) significantly increased gastric motility in FD rats.

A multimodal transformer to fuse images and metadata for skin disease classification.

Skin disease cases are rising in prevalence, and the diagnosis of skin diseases is always a challenging task in the clinic. Utilizing deep learning to diagnose skin diseases could help to meet these challenges. In this study, a novel neural network is proposed for the classification of skin diseases.

Mechanism of Elian granules in the treatment of precancerous lesions of gastric cancer in rats through the MAPK signalling pathway based on network pharmacology.

Context: Elian Granules have been applied in the treatment of precancerous lesions of gastric cancer (PLGC) and achieved good results. However, its exact mechanism remains unclear.

Objectives: To explore the mechanism of Elian granules in treating PLGC through the mitogen-activated protein kinase (MAPK) signalling pathway based on network pharmacology.

3D hierarchical rose-like NiP@rGO assembled from interconnected nanoflakes as anode for lithium ion batteries.

In recent years, anode materials of transition metal phosphates (TMPs) for lithium ion batteries (LIBs) have drawn a vast amount of attention from researchers, due to their high theoretical capacity and comparatively low intercalation potentials Li/Li. However, in practice, their application remains constrained by poor electrical conductivity, and dramatic volume expansion and severe agglomeration during the lithium process, which leads to questionable kinetic issues and a prompt decline in capacity during cycling. Herein, through an elaborate design, we developed a novel three-dimensional (3D) hierarchical rose-like architecture self-assembled from two-dimensional (2D) NiP nanoflakes immobilized on reduced graphene oxide (rGO) a combination of a hydrothermal process and phosphating treatment.

Bioleaching of silicon in electrolytic manganese residue using single and mixed silicate bacteria.

Electrolytic manganese residue (EMR) is a type of industrial solid waste with a high silicon content. The silicon in EMR can be used as an essential nutrient for plant growth, but most of the silicon is found in silicate minerals with very low water solubility, that is, it is inactive silicon and cannot be absorbed and used by plants directly. Thus, developing a highly effective and environmentally friendly process for the activation of silicon in EMR is important both for reusing solid waste and environmental sustainability.

[Non-contacting photoacoustic tomography in biological samples].

In photoacoustic imaging the ultrasonic signals are usually detected by contacting transducers. For some applications, contact with the tissue should be avoided, e.g.

The current role and therapeutic targets of vitamin D in gastrointestinal inflammation and cancer.

Vitamin D, beyond its classical roles in the regulation of calcium and phosphorus homeostasis and bone metabolism, has been implicated in multiple pathological processes, including progression from inflammation to cancer development and also involvement in autoimmune diseases as well as cardiovascular disorders. In this review, we shall discuss the different roles of vitamin D and its therapeutic targets in different gastrointestinal diseases, focusing on colorectal cancer (CRC) and inflammatory bowel disease (IBD). To this end, vitamin D deficiency has been identified as a risk factor of CRC.

Etiology and morphology of carditis: experiences from a single center in China.

Objective: To investigate the type of cardiac mucosa and its relationship with age and gender of the participants and to determine the coincidence of endoscopic and pathological diagnosis of carditis as well as its etiology.

Methods: The data of 70 patients with carditis (the carditis group) and 30 individuals with endoscopically normal-appearing cardiac mucosa (the control group), including their baseline characteristics and histopathological findings, were reviewed. Their Helicobacter pylori (H.

Comparison of intestinal metaplasia in gastric cardia and Barrett's esophagus.

Objective: To evaluate and compare the pathological features and immunostaining pattern (cytokeratin 7 (CK-7), mucin core peptide 1 (Muc-1)) in Barrett's esophagus (BE) and cardiac intestinal metaplasia (CIM).

Methods: According to endoscopic diagnosis, patients with gastric cardiac inflammation and BE were selected from March 2008 to February 2009 in Renji Hospital, Shanghai Jiaotong University School of Medicine. Those patients who had histological findings of intestinal metaplasia (82 cases of CIM and 64 special type BE) were enrolled in our study.

Expression of polycomb protein EZH2 in multi-stage tissues of gastric carcinogenesis.

Objective: To study the role and significance of the polycomb group (PcG) protein EZH2 (enhancer of zeste homolog 2) in the multi-step process of intestinal-type gastric carcinogenesis.

Methods: Gastric specimens were obtained from 142 patients with gastric disease, including 34 with chronic non-atrophic gastritis (NCAG), 33 chronic atrophic gastritis (CAG) with intestinal metaplasia (IM), 40 CAG with dysplasia (DYS) and 35 with intestinal-type gastric carcinomas (GC), and 32 Helicobacter pylori-negative controls. The EZH2 protein was stained by the immunohistochemical method and was expressed as the intensity and percentage of the total number of epithelial cells.

[Content of somatostatin and cholecystokinin-8 in hypothalamus and colons in a rat model of spleen-deficiency syndrome].

Objective: To investigate the changes of neuropeptides content in a rat model of spleen-deficiency syndrome.

Methods: Rats were randomly divided into three groups: normal group, untreated group and treatment group. There were ten rats in each group.

[Clinical study of chronic renal failure with syndrome of dampness-heat due to spleen deficiency treated with Jianpi Qinghua Recipe].

Objective: To evaluate the effects of Jianpi Qinghua Recipe (JPQHR) on chronic renal failure with syndrome of dampness-heat due to spleen deficiency and its mechanism.

Methods: One hundred and six patients were randomly divided into two groups: control group (53 patients treated with routine therapy) and JPQHR-treated group (53 patients treated with routine therapy and JPQHR).

Results: Routine therapy combined with JPQHR could improve symptoms.

[Observation on intestinal flora in patients of irritable bowel syndrome after treatment of Chinese integrative medicine].

Objective: To observe the clinical efficacy of the combination of traditional Chinese medicine and western medicine in treating irritable bowel syndrome (IBS) and the result of intestinal flora regulation.

Methods: Sixty IBS patients, 36 males and 24 females, were divided into two groups, with 30 patients in each group. Herbal formula of TongxieYaofang and clostridium butyricum (Cb) were used in the first group for four weeks, while only Cb was used for four weeks in the second group.

[Randomized controlled clinical study on effect of Chinese compound changjitai in treating diarrheic irritable bowel syndrome].

Objective: To verify the clinical efficacy and safety of the proven Chinese Compound Changjitai (CJT), in treating the diarrheic irritable bowel syndrome (DIBS).

Methods: Randomized controlled open clinical trial design was adopted, 45 patients were randomly divided into two groups, CJT and pinaverium bromide (PVB) were given as treated and control agent respectively. IBS scoring system (BSS), defecation state questionnaire (DSQ) were used to record the changes of the patients' main symptoms before and after treatment.

A comparison between Zhishi Xiaopiwan and cisapride in treatment of functional dyspepsia.

AIM:To compare the therapeutic effect of the herbal medicine Zhishi Xiaopi with that of Cisapride in the treatment of functional dyspepsia (FD).METHODS:Fifty-one FD patients were randomized into Herbal group (n =27) and Cisapride group (n =24). Two two groups were given a four-week treatment of Zhishi Xiaopi 100ml, tid, a.