[Diagnosis and clinical features of non-exudative macular neovascularization].

Macular neovascularization (MNV) is the process of new abnormal blood vessels formation in the choroid and/or retina. The widespread adoption of optical coherence tomography angiography (OCTA) has significantly expanded the possibilities of not only detecting pathological blood flow before the development of exudation and deterioration of visual acuity, but also determining its characteristics. The purpose of this review is to substantiate the criteria for choosing terminology and diagnostic markers of MNV.

[Choroidal microvascular dropout as a biomarker of glaucoma progression in patients with diabetes mellitus].

Purpose: To study the occurrence, features of the development of choroidal microvascular dropout (CMvD) as a possible marker of the severity of the glaucoma process and to assess the impact of diabetes mellitus (DM) on the progression of these changes.

Material And Methods: The study included 258 eyes (258 patients), which were divided into groups: 1st - 58 patients (58 eyes) with stage I POAG and DM; 2nd - 50 patients (50 eyes) with stage I POAG; 3rd - 50 patients (50 eyes) with stage III POAG and DM; 4th - 50 patients (50 eyes) with stage III POAG; 5th - 50 patients (50 eyes) with DM. The observation period lasted 24 months.

[New findings on pathogenetic mechanisms in the development of age-related macular degeneration].

Age-related macular degeneration (AMD) is a complex multifactorial disease that occurs due to disfunction and degeneration of retinal pigment epithelium (RPE) and choriocapillaris, as well as death of photoreceptors. The exact pathogenetic mechanism remains uncertain. The aging process is the main and the clearest risk factor of AMD.

[Features of structural and microvascular changes of the choroid in angioretinopathy of various etiologies].

Purpose: To study structural and microvascular changes in the choroid in patients with chronic kidney disease (CKD), diabetic retinopathy (DR) and arterial hypertension (AH), and their relationship with the level of renal function, carbohydrate metabolism and blood pressure.

Material And Methods: The study involved 172 patients (325 eyes): 56 patients with CKD (109 eyes); 66 patients with DR (121 eyes); 50 patients with AH (95 eyes). All patients underwent comprehensive ophthalmological examination including visometry, biomicroscopy, ophthalmoscopy, optical coherence tomography (OCT) and OCT angiography.

[Structural and microvascular changes in the retina and choroid in patients with chronic kidney disease].

Purpose: To study the main structural and microvascular changes in the retina and choroid in patients with diabetic retinopathy (DR) and chronic kidney disease (CKD), and their relationship with impaired renal function.

Material And Methods: The study included 158 patients (304 eyes). The 1 group consisted of 50 patients with CKD (97 eyes); group 2 - 65 patients with DR (119 eyes), group 3 - 43 patients with CKD and DR (86 eyes).

[Ophthalmic safety profile of antiangiogenic therapy].

Antiangiogenic therapy with inhibitors of vascular endothelial growth factor (anti-VEGF) has not only fundamentally changed the treatment outcomes of vasoproliferative eye diseases, but also became the most common ophthalmic surgical manipulation. At the same time, in 36-48% of bilateral lesions there is a need to perform injections in both eyes, making relevant the issues of safety and prevention of severe complications that threaten irreversible loss of visual function. The article reviews the results of randomized clinical trials and real clinical practice, analyzes the incidence and causes of its most dangerous complication - endophthalmitis, characterizes the clinical course depending on the type of drug used, and considers the possibility of reducing the risk of this complication occurring.

[Anti-angiogenesis therapy of diabetic macular edema in patients with primary open-angle glaucoma].

Unlabelled: Despite the high clinical effectiveness and widespread introduction of anti-angiogenesis (anti-VEGF) therapy into practice, its long-term effect on the development of structural changes in the treatment of primary open-angle glaucoma (POAG) patients with diabetic macular edema (DME) hasn't been studied sufficiently and so presents certain interest.

Purpose: To study the effect of anti-VEGF therapy on the structural and functional state of the retina and optic nerve in patients with DME and POAG.

Material And Methods: The study included 72 patients (132 eyes): the 1 group - 22 patients (40 eyes) with stage I POAG and DME, the 2 group - 25 patients (46 eyes) with DME receiving anti-VEGF therapy.