Publications by authors named "Gambichler T"
Background: Cancer immunotherapy has revolutionized melanoma treatment, but the high number of non-responders still emphasizes the need for improvement of therapy. One potential avenue for enhancing anti-tumor treatment is through the modulation of coagulation and platelet activity. Both have been found to play an important role in the tumor microenvironment, tumor growth and metastasis.
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- Herpes zoster (HZ) significantly impacts individual and public health, and a study analyzed clinical and laboratory data from 520 hospitalized HZ patients to identify key prognostic indicators.* ! -
- Results showed that systemic immune inflammatory biomarkers (like NLR and PIV) were much higher in HZ patients than healthy individuals, with absolute eosinopenia being a strong predictor for herpes zoster ophthalmicus (HZO).* ! -
- Key findings linked immunosuppression to a higher risk of herpes encephalitis and longer hospital stays, while not receiving intravenous antiviral therapy increased the likelihood of postherpetic neuralgia.* !
Background: Laboratory-based biomarkers accurately presenting systemic lupus erythematosus (SLE) disease activity may have a practical value in clinical routine. As shown in many other conditions, complete blood count (CBC)-derived biomarkers may also play a role in SLE.
Objectives: We aimed to study for the first time the pan-immune-inflammation value (PIV, monocytes x platelets x neutrophils/lymphocytes) and the more established systemic immune-inflammation index (SII, neutrophils x platelets /lymphocytes) in SLE patients and correlate it with serological and clinical findings including disease outcomes.
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- The study investigates the effects of primary tumor (PT) on the immune activity and metastatic status of sentinel lymph nodes (SLNs) in melanoma patients.
- It finds that SLNs removed shortly after PT (IM-SLNs) show a higher incidence of micrometastases and lower immune activity compared to those removed later (DEL-SLNs).
- Higher immune activity and the presence of specific immune cells in DEL-SLNs suggest that the timing of SLN removal influences prognosis, with DEL-SLNs indicating a worse outcome due to the melanoma's ability to evade immune responses.
Immune responses of the epithelia of the upper respiratory tract are likely crucial in early inhibition of the viral replication and finally clearance of SARS-CoV-2. We aimed to compare the expression profiles of antimicrobial peptides/proteins (AMPs) and related cytokines observed in the nasopharynx of SARS-CoV-2-infected patients and non-infected controls and to assess the associations between these parameters and COVID-19 patients' outcomes. We included 45 subjects who had tested positive for SARS-CoV-2 and 22 control subjects who had tested negative for SARS-CoV-2.
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- Neoadjuvant and adjuvant therapies are becoming increasingly important in treating cutaneous melanoma (CM), but there is still a need for better prognostic tools to identify patients at high risk.
- Recent evidence suggests that liver scores could serve as potential prognostic indicators across various tumor types, prompting an investigation into their relevance for CM prognosis.
- A study involving 423 patients demonstrated that while tumor thickness and ulceration were key predictors of survival across all stages, liver scores like the APRI showed significant associations with survival outcomes specifically in earlier stages (I and II) of melanoma.
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- * Significant findings include higher neutrophil-to-lymphocyte ratio (NLR) and pan-immune-inflammation value (PIV) in SOCV patients compared to healthy controls, along with specific predictors of disease severity and hospitalization length.
- * Key results show that upper extremity manifestations suggest milder disease, while older age and lower serum C3 levels predict longer hospital stays and higher recurrence rates, highlighting the importance of these factors in patient prognosis.
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- Mycosis fungoides (MF) is a common type of skin cancer that makes it hard to tell harmful T cells from normal ones.
- Researchers used single-cell RNA and T-cell receptor sequencing on skin samples from 12 MF patients, analyzing 18,630 T cells from 9 of them to distinguish between malignant and reactive cells.
- The study found unique gene signatures in malignant T cells that could help differentiate them from reactive T cells, revealing significant variations in cell characteristics among patients.
Introduction: Merkel cell carcinoma (MCC) is an aggressive skin cancer with a poor prognosis, which only improved with the introduction of immunotherapies. An MCC prediction model with high diagnostic accuracy is lacking. The aim was to develop an MCC prognostic score (MCC-PS) based on combinations of previously proposed risk factors.
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- Hidradenitis suppurativa (HS) is a chronic inflammatory condition that significantly increases the risk of various cancers, with the risk reaching up to 50% in patients.
- A systematic review examined 443 initial publications, identifying 25 studies that showed a correlation between the severity of HS and the likelihood of specific malignancies like oropharyngeal, colorectal, and skin cancers.
- Complicated malignant transformations can occur in severe HS cases, leading to cutaneous squamous cell carcinoma (cSCC), but the underlying mechanisms for these changes are still not fully understood.
Background: Pigmented lesions such as melanosis have rarely been reported in patients with vulvar lichen sclerosus (VLS) that is typically characterized by hypopigmented lesions.
Objective: We aimed to analyze systematically anogenital melanosis in a large cohort of VLS patients.
Methods: We analyzed the clinical data of 198 female patients with VLS.
Article Synopsis
- - Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer, primarily affecting older and immunocompromised individuals, prompting increased attention to immunotherapy and vaccines as treatment options.
- - Recent research includes identifying 10 articles and 9 ongoing clinical trials focused on vaccines for MCC, with most studies being in early phases of development.
- - Various vaccine strategies are being explored, including DNA, synthetic peptide vaccines, RNA-based vaccines, oncolytic viruses, and combinations with immunotherapy, though it may take time for a vaccine to be approved for clinical use.
In patients with COVID-19, broad panels of immune checkpoint molecules (ICPMs) and the purinergic signaling have not been studied in parallel. We aimed to perform in-depth immunophenotyping of major cell subsets present in human peripheral blood of COVID-19 patients and controls using PD1, TIM3, LAG3, TIGIT, and CD200R, as well as CD39, as markers for the purinergic signaling pathway. We studied 76 COVID-19 patients and 12 healthy controls using peripheral blood mononuclear cells on flow cytometry.
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- The study focuses on two types of immune complex vasculitides in adults: IgA small vessel vasculitis (aIgA-SVV) and non-IgA small vessel vasculitis (non-IgA-SVV).
- Researchers analyzed clinical and laboratory data from 29 patients with aIgA-SVV and 53 with non-IgA-SVV to identify differences in their conditions.
- Key findings revealed that patients with aIgA-SVV showed higher rates of proteinuria and haematuria, while non-IgA-SVV patients had a higher platelet-to-lymphocyte ratio, indicating notable clinical distinctions between the two groups.
Comments on the first European guideline for paraneoplastic autoimmune multiorgan syndrome.
J Eur Acad Dermatol Venereol
July 2024
Hidradenitis suppurativa (HS) is a chronic skin disease that can have an association with endocrine disorders. There is conflicting information in the literature regarding the role of the thyroid gland in HS. This study aimed to close this knowledge gap and investigate how thyroid disease is involved in patients with HS.
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