Publications by authors named "Gamallo M"

Background: The global burden associated with antimicrobial resistance is of increasing concern.

Aim: To evaluate risk factors associated with multidrug-resistant (MDR) infection and its clinical impact in a cohort of patients with healthcare-associated bacteraemic urinary tract infections (BUTIs).

Methods: This was a prospective, multicentre, post-hoc analysis of patients with healthcare-associated-BUTI (ITUBRAS-2).

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In recent years, the application of magnetic nanoparticles as alternative catalysts to conventional Fenton processes has been investigated for the removal of emerging pollutants in wastewater. While this type of catalyst reduces the release of iron hydroxides with the treated effluent, it also presents certain disadvantages, such as slower reaction kinetics associated with the availability of iron and mass transfer limitations. To overcome these drawbacks, the functionalization of the nanocatalyst surface through the addition of coatings such as polyacrylic acid (PAA) and their immobilization on a mesoporous silica matrix (SBA15) can be factors that improve the dispersion and stability of the nanoparticles.

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Article Synopsis
  • The study investigates healthcare-associated (HCA) bacteremic urinary tract infections (BUTI), comparing community-onset (CO-HCA) and hospital-acquired (HA) cases, particularly focusing on multidrug resistance (MDR) and outcomes.
  • Conducted as a multicenter cohort study, it involved adult patients with specific inclusion and exclusion criteria, looking at factors like mortality and treatment appropriateness.
  • Results showed a high prevalence of MDR (61.2%) among patients, with CO-HCA-BUTI patients generally older and sicker than those with HA-BUTI; however, mortality rates were not influenced by infection acquisition site or MDR presence.
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The pressure on natural water resources associated with increasing water scarcity highlights the value of using reclaimed water through the development of efficient and environmentally friendly treatment technologies. In this work, the use of magnetic nanoparticles in photo-Fenton catalysis for water disinfection was considered to inactivate natural enteric bacteria present in municipal wastewater effluents under white light and neutral pH. The most recommended ranges were evaluated in key variables such as the loading and composition of nanoparticles (NPs), hydrogen peroxide (HO) concentration, the light source (UV and visible) and treatment time were evaluated in wastewater disinfection expressed in terms of total coliforms and Escherichia coli colony forming units (CFU).

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The purpose of this research was the preparation and photocatalytic evaluation of a novel nanocomposite (NC) based on FeO/ZnO, to eliminate four persistent antibiotics in surface waters: sulfamethoxazole, trimethoprim, erythromycin and roxithromycin. Prior to the operation of the photocatalytic reactor, the influence of pH (3-9), catalyst concentration (50-800 mg L, oxidant dose (0-100 mg L) and concentration of different targets (10-100 μg L) on the catalytic efficiency was evaluated. The analysis of reaction kinetics showed that degradation processes of the four antibiotics followed a pseudo-first-order kinetic model.

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