Publications by authors named "Gamal A Allam"
Article Synopsis
- Schistosomiasis affects around 250 million people globally and contributes to approximately 280,000 deaths every year due to severe inflammatory reactions that lead to high mortality rates.
- This study investigates the effects of plumbagin, a compound with noted anti-inflammatory and anthelmintic properties, on mice infected with schistosomes, showcasing significant reductions in infection rates and liver damage compared to untreated groups.
- Plumbagin treatment not only decreased various inflammatory markers and improved immune responses but also enhanced liver enzyme activities, indicating its potential use as an effective treatment for schistosomiasis.
Heavy metals (HMs) constitute a group of persistent toxic pollutants, and the petroleum industry is one of the sources of these metals. This study aimed to evaluate the levels of lead (Pb), cadmium (Cd), nickel (Ni), and vanadium (V) in Plantago ovata and milk and tissues of domestic goats in the eastern region of Saudi Arabia. Plant samples and blood, milk, muscle, liver, and kidney samples were collected from domestic goats and the levels of Pb, Cd, V, and Ni were determined.
View Article and Find Full Text PDFThe petroleum industry can impact the environment and human health. Heavy metals (HMs), including lead (Pb), cadmium (Cd), nickel (Ni), and vanadium (V), are toxic pollutants found in petroleum that can cause several severe diseases. This study investigated the impact of the oil industry on the Arabian camel () in the eastern region of Saudi Arabia, pointing to HMs accumulation, tissue injury, redox imbalance, inflammation, and apoptosis.
View Article and Find Full Text PDFEffect of Visnagin on Altered Steroidogenesis and Spermatogenesis, and Testicular Injury Induced by the Heavy Metal Lead.
Comb Chem High Throughput Screen
November 2021
Background: Lead (Pb) is an environmental pollutant causing serious health problems, including impairment of reproduction. Visnagin (VIS) is a furanochromone with promising antioxidant and anti-inflammatory effects; however, its protective efficacy against Pb toxicity has not been investigated.
Objective: This study evaluated the protective effect of VIS on Pb reproductive toxicity, impaired steroidogenesis and spermatogenesis, oxidative stress and inflammation.