Publications by authors named "Galyna V Ostrovska"
Article Synopsis
- Endogenous cytokinins in medicinal mushrooms Hericium coralloides and Fomitopsis officinalis were identified using advanced chromatography techniques, revealing species-specific traits especially high levels of zeatin-type cytokinins and isopentenyladenine.
- Purified cytokinin fractions from both mushroom species displayed cytotoxic effects on HepG2 tumor cells, promoting increased apoptosis and glucose uptake, with H. coralloides exhibiting more pronounced effects compared to F. officinalis.
- The study suggests that the extraction methods of cytokinins are crucial for developing pharmacologically active drugs, highlighting the potential of these mushroom extracts as anticancer agents.
Morpho-Functional Characteristics of Bone Marrow Multipotent Mesenchymal Stromal Cells after Activation or Inhibition of Epidermal Growth Factor and Toll-Like Receptors or Treatment with DNA Intercalator Cisplatin.
Iuliia Golovynska Olesia Kalmukova Hanna M Svitina Vitaliy M Kyryk Volodimir A Shablii Galyna V Ostrovska
Cytometry A
January 2019
This study is aimed to reveal morphological and functional changes in multipotent mesenchymal stromal cells (MSCs) isolated from the rat bone marrow after: (i) activation of Toll-like receptors (TLRs) with teichoic acid (TA), (ii) impact on epidermal growth factor (EGF) receptors with activator EGF or inhibitor Herceptin, and (iii) treatment with DNA intercalator Cisplatin. According to our results, TA and EGF cause an increase in the synthesis of glycosaminoglycans, c-Myc content, and protein in the MSC cytoplasm. It was observed that the cell population in G0 phase decreased and the cell population in G1 phase increased, when compared with control.
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