Tetrac Delayed the Onset of Ocular Melanoma in an Orthotopic Mouse Model.

Ocular melanoma research, the most common primary intraocular malignancy in adults, is hindered by limited models. In a series of experiments using melanoma cells injected intraocularly into mouse eyes, we developed a model for ocular melanoma. Inoculation of 5 × 10 B16F10 cells led to rapid tumor growth, extensive lung metastasis, and limited animal survival, while injection of 10 cells was sufficient for intraocular tumors to grow with extended survival.