Prostate cancers with distinct transcriptional programs in Black and White men.

Background: Black men are at a higher risk of prostate cancer (PC) diagnosis and present with more high-grade PC than White men in an equal access setting. This study aimed to identify differential transcriptional regulation between Black and White men with PC.

Methods: We performed microarray of radical prostatectomy tissue blocks from 305 Black and 238 White men treated at the Durham Veterans Affairs Medical Center.

Intraoral Soft Tissue Lesions in 6-Year-Old Schoolchildren in Regions of Southern Ecuador: An Epidemiological Study.

Oral Mucosal Lesions (OMLs) are conditions of the oral mucosa that cause alterations in their presentation and pain in the affected patient, highlighting their importance for study. The aim of this research is to determine the prevalence of oral lesions in the Ecuadorian Austro. Descriptive statistics were used to associate variables, yielding statistically significant findings based on oral lesions, sex, and geographical environment.

27-hydroxycholesterol and DNA damage repair: implication in prostate cancer.

Introduction: We previously reported that cholesterol homeostasis in prostate cancer (PC) is regulated by 27-hydroxycholesterol (27HC) and that CYP27A1, the enzyme that converts cholesterol to 27HC, is frequently lost in PCs. We observed that restoring the CYP27A1/27HC axis inhibited PC growth. In this study, we investigated the mechanism of 27HC-mediated anti-PC effects.

The effects of glycemic index on prostate cancer progression in a xenograft mouse model.

Background: Previously, we found low-carbohydrate diets slowed prostate cancer (PC) growth and increased survival vs. a Western diet in mice, by inhibiting the insulin/IGF-1 axis. Thus, we tested whether modifying carbohydrate quality to lower glycemic index (GI) without changing quantity results in similar benefits as with reduced quantity.

Diversity of vegetable landraces in the Pampa biome of Brazil and Uruguay: utilization and conservation strategies.

The historical meeting between originally American people, European colonizers, and slaved peoples from Africa in the biome Pampa in South Brazil and Uruguay involved a cultural syncretism and a great genetic diversity of landraces of cultivated species. Genetic richness evolved by selection and cultural processes in response to different environments, cultural backgrounds, and needs. This review summarized the knowledge on vegetable and maize landraces in South Brazilian and Uruguayan Pampa biome, to design a strategy towards the rediscovery, conservation, and sustainable use.

A Robust Initialization of Residual Blocks for Effective ResNet Training Without Batch Normalization.

Batch normalization is an essential component of all state-of-the-art neural networks architectures. However, since it introduces many practical issues, much recent research has been devoted to designing normalization-free architectures. In this brief, we show that weights initialization is key to train ResNet-like normalization-free networks.

Relative search popularity of five advanced prostate cancer medications using Google Trends.

Background: There are many FDA-approved drugs for advanced prostate cancer (PC), yet public interest in these drugs is not well understood. We compared public interest and state-level predictors of interest in five common oral adjunctive hormonal therapies.

Methods: Google Trends™ was queried for: "Enzalutamide", "Abiraterone Acetate", "Bicalutamide", "Apalutamide", and "Darolutamide" in the United States from January 2004 to November 2022.

Genetic diversity of thrips populations on Allium species around the world.

Thrips are a serious pest in many crops. In onion cultivation, Thrips tabaci is the most important, but not the only thrips species causing damage. We investigated which thrips species affects onion and related species worldwide, how much genetic variation there is within T.

Investigating trends in interest for benign prostatic hyperplasia surgery options using Google Trends.

Understanding patient interest among surgical options is challenging. We used Google Trends to analyze interest in benign prostatic hyperplasia (BPH) surgeries recommended for prostate volumes <80 cc. Google Trends was queried with five BPH surgeries.

Co-exposure effects of lead and TiO nanoparticles in primary kidney cell culture from the freshwater fish Hoplias malabaricus.

This study evaluated the effects of Lead (Pb) and titanium dioxide nanoparticles (TiO NPs) alone or in combination in anterior kidney macrophages of the freshwater fish Hoplias malabaricus, naïve or stimulated with 1 ng.mL lipopolysaccharide (LPS). Pb (1 ×10 to 1 ×10 mg.

Key takeaways for knowledge expansion of early-career scientists conducting Transdisciplinary Research in Energetics and Cancer (TREC): a report from the TREC Training Workshop 2022.

The overall goal of the annual Transdisciplinary Research in Energetics and Cancer (TREC) Training Workshop is to provide transdisciplinary training for scientists in energetics and cancer and clinical care. The 2022 Workshop included 27 early-to-mid career investigators (trainees) pursuing diverse TREC research areas in basic, clinical, and population sciences. The 2022 trainees participated in a gallery walk, an interactive qualitative program evaluation method, to summarize key takeaways related to program objectives.

Avocados: A Recipe for Good Guacamole or Lower Cancer Risk?

Diet plays a role in modifying cancer risk. This study from Ericsson and colleagues provides new evidence suggesting that avocado intake could aid in cancer prevention. However, these effects were observed only in men, pointing to intriguing key differences by sex.

Relationship Between Weight and Severity of Fibromyalgia.

Unlabelled: Fibromyalgia is a chronic pain syndrome with diffuse pain, muscle weakness, and other symptoms. A relationship between the severity of symptoms and obesity has been observed.

Objective: To determine the relationship between weight and the severity of fibromyalgia.

[Bacterial infections in COVID-19 patients hospitalized in intensive care unit].

In this brief communication, we retrospectively describe COVID-19 severe patient's characteristics in ICU, and report 37,6% of secondary bacterial infections, mainly with nosocomial respiratory infections and rarely from community source.

Phylogeny and Identification of Species Associated with Bulb Rot and Bacterial Leaf Blight of Onion Crops in Uruguay.

Onion is among the most consumed vegetables in Uruguay, grown in the northwestern and southern regions of the country. The onion supply presents interannual variations associated with significant postharvest losses, mainly caused by bacterial rots. Besides bulb rotting, onion leaf lesions as well as infections on seed-stalks during seed production may be devastating for some varieties under conducive conditions.

[Perceived emotional intelligence and consumption of psychoactive substances in scholarshiped adolescents of Montería, Colombia].

It was compared the level of perceived emotional intelligence (PEI) with prevalence or not prevalence of life of use of psychoactive substances (PLU-PS or n-PLU-PS) in 559 school adolescents in the city of Monteria, Colombia [men 49.69%, women 50.4%, average age 15 and range 12-18 years].

The Distribution of Onion Virulence Gene Clusters Among spp.

is a gram-negative bacterium and the primary causal agent of center rot of onions in Georgia. Previous genomic studies identified two virulence gene clusters, HiVir and , associated with center rot. The HiVir gene cluster is required to induce necrosis on onion tissues via synthesis of pantaphos, (2-hydroxy[phosphono-methyl)maleate), a phosphonate phytotoxin.

Obesity-Modified CD4+ T-Cells Promote an Epithelial-Mesenchymal Transition Phenotype in Prostate Cancer Cells.

Obesity is associated with low-grade chronic inflammation, and metabolic dysregulation. Evidence shows that chronic inflammation inhibits protective immunity mediated by CD4+ T cells. Additionally, obesity-induced inflammation affects prostate cancer progression.

The Multi-Component Smoking Cessation Support Programme (McSCSP) is effective in patients with severe mental disorder without gender differences.

High prevalence of smoking in people with severe mental disorders (SMD) contributes to their medical morbidity and reduced life expectancy. Despite the evidence of gender differences in smoking cessation, few studies have tested those differences among people with SMD. This is a non-randomized, open-label, prospective, 9-month follow-up multicentre trial to examine gender differences in the efficacy, safety and tolerability of a Multi-Component Smoking Cessation Support Programme (McSCSP).

Diversity of Bee Assemblage (Family Apidae) in Natural and Agriculturally Intensified Ecosystems in Uruguay.

Bees (Family Apidae) hold a key role as pollinators in a wide range of angiosperm communities. South America suffered strong modifications during the last decade due to increasing anthropic activities and the expansion of agricultural areas, particularly the boom of soybean. The goal of this research was to know the current diversity of bees in South and Low Littoral regions in Uruguay.

[Impulsivity and gender in adolescents who use psychoactive substances of higher prevalence (alcohol, tobacco and cannabis)].

The purpose of the study was to describe the relationship between substance use and impulsivity according to gender as a moderating variable in a sample of Argentine students. Three hundred ninety students were evaluated using a sociodemographic and clinical ad hoc questionnaire; the ASSIST test and the Barratt scale were used to detect substance use and impulsiveness levels respectively. Equal percentages of men and women use alcohol and tobacco; a greater proportion of men use cannabis.