Publications by authors named "Gallone G"
Purpose: to evaluate the diagnostic accuracy of late iodine enhancement (LIE) in cardiac computed tomography (CCT) compared to late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR) for myocardial tissue characterization.
Materials And Methods: EMBASE, PubMed/MEDLINE, and CENTRAL were searched for studies reporting the accuracy of LIE with LGE as the gold standard of reference. QUADAS-2 tool was used to assess the risk of bias.
Purpose: Structural variants such as multiexon deletions and duplications are an important cause of disease but are often overlooked in standard exome/genome sequencing analysis. We aimed to evaluate the detection of copy-number variants (CNVs) from exome sequencing (ES) in comparison with genome-wide low-resolution and exon-resolution chromosomal microarrays (CMAs) and to characterize the properties of de novo CNVs in a large clinical cohort.
Methods: We performed CNV detection using ES of 9859 parent-offspring trios in the Deciphering Developmental Disorders (DDD) study and compared them with CNVs detected from exon-resolution array comparative genomic hybridization in 5197 probands from the DDD study.
Introduction: Left ventricular assist device (LVAD) therapy may lead to an aortic regurgitation, limiting left ventricular unloading and causing adverse events. Whether concomitant aortic valve replacement may improve outcomes in patients with preoperative mild-to-moderate aortic regurgitation remains unclear.
Methods: A retrospective propensity score-matched analysis of adult patients with preoperative mild-to-moderate aortic regurgitation undergoing durable LVAD implantation between 01/01/2011 and 30/11/2021 was performed.
Background And Objectives: The risk profiles, procedural characteristics, and clinical outcomes for women undergoing bifurcation percutaneous coronary intervention (PCI) are not well defined compared to those in men.
Methods: COronary BIfurcation Stenting III (COBIS III) is a multicenter, real-world registry of 2,648 patients with bifurcation lesions treated with second-generation drug-eluting stents. We compared the angiographic and procedural characteristics and clinical outcomes based on sex.
Background: Lower limb length discrepancy (LLD) in children and adolescents, often due to congenital or acquired conditions, is treated to achieve limb equality and alignment, optimizing function and minimizing cosmetic concerns for an active adulthood. This study evaluated the Health-Related Quality of Life (HRQoL) and physical functioning of adults who underwent unilateral limb lengthening with circular external fixators (EFs) in childhood.
Methods: Fifty patients treated at a median age of 14.
Background: Heart transplantation and left ventricular assist device (LVAD) implementation are effective treatments for advanced heart failure (HF), although their use is limited by organ availability and the high incidence of adverse events. The efficacy of mitral transcatheter edge-to-edge repair (TEER) as a bridge to transplantation or as a destination therapy in advanced HF is still debated.
Methods: A total of 63 patients with INTERMACS class 3 or 4 with contraindications for LVAD and severe functional mitral regurgitation (FMR) were evaluated for TEER implantation eligibility.
Background: Despite evidence supporting use of fractional flow reserve (FFR) and instantaneous waves-free ratio (iFR) to improve outcome of patients undergoing coronary angiography (CA) and percutaneous coronary intervention, such techniques are still underused in clinical practice due to economic and logistic issues.
Objectives: We aimed to develop an artificial intelligence (AI)-based application to compute FFR and iFR from plain CA.
Methods And Results: Consecutive patients performing FFR or iFR or both were enrolled.
Article Synopsis
- Coronary access (CA) and percutaneous coronary intervention (PCI) can be more difficult after valve-in-valve transcatheter aortic valve replacement (ViV-TAVR), especially with certain valve designs.* -
- A study found that the ACURATE neo2 valve led to significantly better success rates for both CA (96.7%) and PCI (98.3%) compared to the Evolut PRO+ valve (75% and 85%, respectively).* -
- The design differences between the valves affected procedural approaches, with ACURATE neo2 allowing for easier access due to a greater valve-to-anatomy distance.*
Aims: Haemodynamic assessment can be determinant in phenotyping cardiogenic shock (CS) and guiding patient management. Aim of this study was to evaluate the correlation between echocardiographic and invasive assessment of haemodynamics in acute decompensated heart failure-related CS (ADHF-CS).
Methods And Results: All consecutive ADHF-CS patients (SCAI shock stage ≥B) undergoing right heart catheterization (RHC) between 2020 and 2022 were prospectively enrolled.
Article Synopsis
- * In a study of 200 patients with pure CS, 24.5% developed MS, with lower blood pressure, liver damage, and suspected infection identified as independent predictors of its occurrence.
- * MS is associated with higher in-hospital mortality (53.1% vs. 27.8%) and longer hospital stays, while using temporary mechanical support can reduce the chances of death for affected patients.
Article Synopsis
- The study systematically reviewed and meta-analyzed existing research to assess how cardiac magnetic resonance (CMR) characteristics can predict arrhythmic risks in patients with mitral valve prolapse (MVP).
- LGE was found to have a strong and significant correlation with complex ventricular arrhythmias (co-VAs), while other CMR features like mitral regurgitation and prolapse distance did not show significant effects.
- The findings suggest that LGE is crucial for predicting arrhythmia risk in MVP patients, with mitral annular disjunction (MAD) possibly serving as an additional factor for assessment.
Article Synopsis
- The study investigates the prevalence and impact of prosthesis-patient mismatch (PPM) in patients undergoing transcatheter aortic valve replacement (TAVR) on heart damage and mortality.
- A cohort of 963 patients was analyzed, revealing that 18% experienced PPM post-TAVR, with 7.7% having severe cases.
- Those with PPM exhibited significant heart changes after one year, including increased left ventricle size and more paravalvular aortic regurgitation compared to those without PPM.
Article Synopsis
- Stroke after left ventricular assist device implantation is linked to high mortality rates, and the study investigates the incidence and outcomes related to temporary mechanical support methods in patients needing a bridge to durable LVAD.
- A retrospective analysis of 341 patients revealed that early ischemic stroke occurred in 10.8% and hemorrhagic stroke in 2.9% of cases post-d-LVAD implantation, with specific device types and conditions affecting hemorrhagic stroke risks.
- Both ischemic and hemorrhagic strokes significantly correlated with higher one-year mortality rates, indicating a need for careful management in patients undergoing d-LVAD procedures.
Article Synopsis
- Researchers aimed to determine if 24-hour invasive haemodynamic profiling offers better prognostic information than initial assessments for predicting in-hospital death in patients with acute decompensated heart failure cardiogenic shock (ADHF-CS).
- The study included 127 patients, revealing that factors like age and pulmonary elastance (PaE) were strong predictors of mortality; the overall in-hospital death rate was 26.8%.
- Specifically, PaE was the strongest predictor of in-hospital death, with a defined cut-off value, and highlighted the importance of classifying patients based on their haemodynamic measurements for better risk assessment.
Background: We evaluated the potential benefits of renin-angiotensin-aldosterone system inhibitors (RAASi) in patients with left ventricular assist device support.
Methods And Results: A total of 165 consecutive patients undergoing left ventricular assist device implant and alive at 6-month on support were studied. RAASi status after 6-month visit along with clinical reasons for nonprescription/uptitration were retrospectively assessed.
Background And Objective: In everyday clinical practice, medical decision is currently based on clinical guidelines which are often static and rigid, and do not account for population variability, while individualized, patient-oriented decision and/or treatment are the paradigm change necessary to enter into the era of precision medicine. Most of the limitations of a guideline-based system could be overcome through the adoption of Clinical Decision Support Systems (CDSSs) based on Artificial Intelligence (AI) algorithms. However, the black-box nature of AI algorithms has hampered a large adoption of AI-based CDSSs in clinical practice.
View Article and Find Full Text PDFPurpose: To evaluate the health-related quality of life and associated risk factors for Multiple Osteochondromas patients.
Methods: A cross-sectional, observational study was conducted from May to December 2022 during the routine visit to the referral center for rare skeletal disorders. All patients with Multiple Osteochondromas aged ≥ 3 years were included.
Background: Metabolic dysfunction associated steatotic liver disease (MASLD) is associated with an increased risk of coronary artery disease. Computed Tomography Coronary Angiography (CTCA) can assess both the extent and the features of coronary plaques. We aimed to gather evidence about the prevalence and features of coronary plaques among MASLD patients.
View Article and Find Full Text PDFBone defects are a significant health problem worldwide. Novel treatment approaches in the tissue engineering field rely on the use of biomaterial scaffolds to stimulate and guide the regeneration of damaged tissue that cannot repair or regrow spontaneously. This work aimed at developing and characterizing new piezoelectric scaffolds to provide electric bio-signals naturally present in bone and vascular tissues.
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