Pathomorphology of humoral, cellular and combined primary immunodeficiencies.

Histologic, immunohistologic and electron microscopic findings in three children with primary immunodeficiencies are reported. Classical X-linked infantile agammaglobulinemia Bruton was present in case 1 (male, aged 16 years), selective cellular immunodeficiency with thrombopenia in case 2 (male, aged 2 1/2 years) and non-lymphopenic severe combined immunodeficiency in case 3 (male, aged 1 3/4 years). At autopsy, all three cases exhibited unusual types of pneumonia.

Microscopic vasovasostomy and spermatogenesis.

Initial clinical experience with a new microscopic 2-layer anastomosis for vasovasostomy shows that normal patency can be achieved almost every time. Histologic and electron microscopic studies on initial specimens and subsequent ejaculates indicate that stricture is a common cause of failure with conventional vasovasostomy techniques, obstruction of the vas deferens inhibits spermatogenesis and relief of obstruction allows return of spermatogenesis in the vast majority of cases.