Publications by authors named "Gallardo-Higueras A"
Beta-lactam (BL) drugs are the antibiotics most prescribed worldwide due to their broad spectrum of action. They are also the most frequently implied in hypersensitivity reactions with a known specific immunological mechanism. Since the commercialization of benzylpenicillin, allergic reactions have been described; over the years, other new BL drugs provided alternative treatments to penicillin, and amoxicillin is now the most prescribed BL in Europe.
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- Gadolinium-based contrast agents (GBCAs) are commonly used in MRIs to enhance diagnostic sensitivity, but there has been an observed increase in hypersensitivity reactions associated with their use.
- Researchers conducted a systematic review of studies on immediate and delayed hypersensitivity reactions to GBCAs, ultimately selecting 26 relevant articles out of an initial 149.
- The review highlighted that while skin tests for allergy assessment show reasonable accuracy, drug provocation tests are necessary for cases where skin tests are negative, and further research is needed to better understand cross-reactivity among different GBCAs and improve management protocols.
Patterns of Cross-Reactivity in Patients With Immediate Hypersensitivity Reactions to Gadobutrol.
J Investig Allergol Clin Immunol
December 2021
A Comprehensive Prospective Study of the Costs Associated With Evaluation of ß-Lactam Allergy.
J Investig Allergol Clin Immunol
February 2021
Background And Objective: Being labeled as allergic to penicillin (unverified ß-lactam allergy) can result in patients receiving broader-spectrum antibiotics than necessary that may be more toxic, less effective, and/or more expensive than alternative options. Objective: We aimed to evaluate the real costs of evaluating ß-lactam allergy.
Methods: We performed a prospective real-life observational study designed to evaluate all adult patients who consulted for suspected ß-lactam allergy over a 1-year period.