Design of selective Cathepsin inhibitors.

A number of molecular recognition features have been exploited in structure-based design of selective Cathepsin inhibitors.

Dipeptidyl nitrile inhibitors of Cathepsin L.

A series of potent Cathepsin L inhibitors with good selectivity with respect to other cysteine Cathepsins is described and SAR is discussed with reference to the crystal structure of a protein-ligand complex.