Publications by authors named "Galina V Kovaleva"
TRIM14 is an important component of innate immunity that defends organism from various viruses. It was shown that TRIM14 restricted influenza A virus (IAV) infection in cell cultures in an interferon-independent manner. However, it remained unclear whether TRIM14 affects IAV reproduction and immune system responses upon IAV infection in vivo.
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- The TRIM14 protein is involved in both antiviral defense and cancer processes, affecting apoptosis in different ways depending on the type of tumor cells.
- A study investigated the role of human TRIM14 and its mutant form in inducing apoptosis in transgenic loach embryos, revealing increased apoptosis associated with both forms of the gene.
- The findings suggest that TRIM14 promotes cell death during embryonic development through the activation of certain proapoptotic genes, with the mutant version following a different, p53-independent pathway.
The trim14 (pub, KIAA0129) gene encodes the TRIM14 protein which is a member of the tripartite motif (TRIM) family. Previously, we revealed high expression levels of trim14 in HIV- or SIV-associated lymphomas and demonstrated the influence of trim14 on mesodermal differentiation of mouse embryonic stem cells (mESC). In the present work, to elucidate the role of trim14 in normal and pathological processes in the cell, we used two different types of cells transfected with trim14: mESC and human HEK293.
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