Publications by authors named "Galina Skladchikova"
Background: The anti-epileptic drug valproic acid (VPA) has attracted attention as an anti-cancer agent.
Methods: The present study investigated effects of VPA exposure on histone deacetylase (HDAC) inhibition, cell growth, cell speed, and the degree of Erk1/2 phosphorylation in 10 cell lines (BT4C, BT4Cn, U87MG, N2a, PC12-E2, CSML0, CSML100, HeLa, L929, Swiss 3T3).
Results: VPA induced significant histone deacetylase (HDAC) inhibition in most of the cell lines, but the degree of inhibition was highly cell type-specific.
The neural cell adhesion molecule (NCAM) is involved in development of the nervous system, in brain plasticity associated with learning and memory, and in neuronal regeneration. NCAM regulates these processes by influencing cell adhesion, cell migration, and neurite outgrowth. NCAM activates intracellular signaling upon homophilic NCAM binding, and this is a prerequisite for NCAM-stimulated neurite outgrowth.
View Article and Find Full Text PDFArticle Synopsis
- NCAM promotes axonal growth by interacting with FGFR, and also has a lesser-known ATPase activity.
- Researchers confirmed the direct interaction between NCAM and FGFR1 using surface plasmon resonance (SPR) and identified overlapping binding sites for FGFR and ATP through NMR analysis.
- ATP can inhibit the NCAM-FGFR interaction and, consequently, reduce neurite outgrowth, demonstrating a regulatory role in this process.
The neural cell adhesion molecule (NCAM) plays a key role in morphogenesis of the nervous system and in remodeling of neuronal connections accompanying regenerative and cognitive processes. Recently, a new synthetic ligand of NCAM, the C3-peptide, which binds to the NCAM IgI module, has been identified by means of combinatorial chemistry (Rønn, L. C.
View Article and Find Full Text PDF