Epoetin-alpha: preserving kidney function via attenuation of polymorphonuclear leukocyte priming.

Background: Polymorphonuclear leukocyte priming and low grade inflammation are related to severity of kidney disease. Erythropoietin-receptor is present on PMNLs. OBJECTIVESxi: To evaluate the effect of 20 weeks of epoetin-alpha treatment on PMNL characteristics in relation to the rate of kidney function deterioration in patients with chronic kidney disease.

Polymorphonuclear leucocyte priming in long intermittent nocturnal haemodialysis patients--is melatonin a player?

Background: The relationships between sleep quality, melatonin circadian rhythm and polymorphonuclear leucocyte (PMNL) priming during the night of dialysis treatment compared with a night without dialysis were studied in a group of nocturnal haemodialysis (HD) patients.

Methods: Twenty-eight long intermittent nocturnal HD patients were included. Sleep quality was assessed by a questionnaire and wrist actigraphy.

Primed peripheral polymorphonuclear leukocyte: a culprit underlying chronic low-grade inflammation and systemic oxidative stress in chronic kidney disease.

This study characterizes the causal relationship between peripheral polymorphonuclear leukocyte (PMNL) priming, systemic oxidative stress (OS), and inflammation in patients with varying degrees of renal insufficiency (chronic kidney disease [CKD] not on renal replacement therapy [RRT]: continuous ambulatory peritoneal dialysis or hemodialysis [HD]) and healthy control subjects. Rate of superoxide release was measured after stimulation of PMNL with phorbol 12-myristate 13-acetate or zymosan. Priming was estimated by the rate of superoxide release after phorbol 12-myristate 13-acetate stimulation.