Assessment of reinforcement enhancing effects of toluene vapor and nitrous oxide in intracranial self-stimulation.

Rationale: Despite widespread abuse, there are few validated methods to study the rewarding effects of inhalants. One model that may have utility for this purpose is intracranial self-stimulation (ICSS).

Objectives: This study aims to compare and contrast the ICSS reward-facilitating effects of abused inhalants to other classes of abused drugs.