Publications by authors named "Galina D Fadieienko"
Article Synopsis
- Antibiotic resistance significantly affects the treatment success rates for Helicobacter pylori infections, with noted resistance levels in Europe.
- A study analyzed 2,852 naive patients and found that the 3-in-1 single capsule with bismuth, metronidazole, and tetracycline, as well as a quadruple therapy with bismuth, had the highest effectiveness against H. pylori, even with existing resistances.
- For non-naive patients, resistance was even higher, but the same 3-in-1 capsule and triple therapy with levofloxacin showed promising results, highlighting the need for effective treatment options based on resistance patterns.
Objective: The aim: To study the state of the intestinal microbiota (ІМ) in patients with Nonalcoholic fatty liver disease (NAFLD) and to determine changes in its composition at the level of basic phylotypes.
Patients And Methods: Materials and methods: The study included 114 patients with NAFLD with metabolic disorders and 64 patients of control group. Determination of the composition of the ІМ at the level of major phylotypes was performed by identifying total bacterial DNA and DNA of Bacteroidetes, Firmicutes and Actinobacteria by quantitative polymerase chain reaction (PCR) in real time (qRT-PCR) using universal primers for the 16S rRNA gene and taxon-specific primers of production (Thermo Fisher Scientific).