[Intraductal intraepithelial neoplasia and ductal pancreatic carcinoma].

The review of modern achievements in morphology and genetic characteristics of pancreatic tumors with ductal phenotype is presented. Problems of intraductal pancreatic neoplasia (PanIN) as precancerous process for ductal adenocarcinoma are considered in detail.

[Classification of pancreatic exocrine tumours].

Current international histologic classification of exocrine pancreatic tumours is presented. Macro- and microscopic characteristics of benign and malignant tumors are described. The role of immunohistochemistry in differential diagnosis is shown.

[Sygmoid endometriosis].

A case of sygmoid endometriosis is described in a 40-year-old female. After clinical and endoscopic examination, the patient was operated for sigmoid tumor, acute obturation colon obstruction. Histologically diagnosis of intestinal wall endometriosis was established.

[Monoclonal antibody therapy with mabtera of patients with b-cell low grade non-Hodgkin's lymphoma].

The data on monoclonal antibody monotherapy (mabtera, rituximab) in 44 patients with B-cell low grade non-Hodgkin's lymphoma were assessed. Thirty-four of them had received several courses of second- or third line chemotherapy: mabtera was used as first-line therapy in 10. Mabtera was administered in a dose of 375 mg/m2 body surface, once a week, by slow intravenous infusion, 4-14 times depending on effect.

[Merkel's cell cancer].

The authors present histological and immunohistochemical characteristics of a rare skin tumor--merkelioma.

[Cutaneous pseudolymphomas].

Histological and immunohistochemical characteristics of principal types of skin pseudolymphomas, their differential diagnosis with true skin lymphomas are outlined.

[Modern radiology in the differential diagnosis of breast diseases accompanied by calcium micromasses].

The study was undertaken to enhance the efficiency of diagnosis of breast cancer shown up as calcium micromasses since breast diseases appear as clusters of 50-600-um calciferous inclusions that are not inclined to the formation of conglomerates without a visible node on a X-ray film, may be a manifestation of both sclerosing adenosis and nonpalpable cancer. Of the examined 4500 females aged 15 to 83 years, breast calcium masses were detected in 207. Of them, 39 females were found to have clustered calcium micromasses without a node on a X-ray film; in them cancer and sclerosing adenosis were diagnosed in 28 (71.

[Tumors of the thymus].

Tumours of the thymus include heterogenic group of benign and malignant organ-specific (thymomas and carcinoma) and organ-nonspecific (neuroendocrine, germinogenic tumours, lymphomas and others) neoplasms. Histologic classifications are now the most useful for the correlation with prognosis and clinical manifestations. It is obligatory to do verification of the progression stage.

[Cytologic differential diagnosis of various peripheral lung cancers].

The data on 25 cases of histologically verified bronchioloalveolar carcinoma and papillary adenocarcinoma are discussed. Reliable differential diagnostic cytological features of both diseases were established using a statistical, program and fine-needle biopsy findings. Statistical analysis data pointed to the sets of cytological features: "serial pattern--clear cell boundaries" and "serial pattern--presence of macrovacuoles" as a major factor of accuracy of bronchiolo-alveolar carcinoma and papillary adenocarcinoma diagnosis.

[Pagetoid reticulosis].

Pagetoid reticulosis is a rare form of T-cell skin lymphoma. A case of this disease is reported.

[Combination therapy of lung cancer with metastatic pleurisy].

The data on the surgical and combined treatment of 35 cases of lung cancer associated with pleural effusion detected during surgery have been evaluated. Mean 5-year survival was 68.5%, pleural effusion--70%.

[Radiation diagnosis of bronchioloalveolar cancer].

The paper analyzes the results of examination of 260 patients with bronchioloalveolar cancer (BAC) who were followed up at the Russian Research Center of Radiology and Roentgenology for 30 years. It provides its clinical, X-ray, and morphological manifestations and classification and the methodological aspects of differential diagnosis. An optimum radiation diagnosis programme has been drawn up, which involves currently available procedures, including computed tomography.

[Correlation of clinical effect, pathological response of tumor cells and the end results of combined treatment of locally advanced breast cancer].

A correlation was established between the end-results of neoadjuvant chemotherapy for locally-advanced breast cancer and pathological response of tumor cells. Also, the end-results correlated with CR or PR and pathological response. Only a small proportion of patients with tumor progression were registered as stage III or IV of pathological response (0.

[Role of induction chemo- and radiotherapy in the treatment of locally advance breast cancer].

336 patients with locally-advanced breast cancer underwent neoadjuvant chemotherapy or chemoradiotherapy. Increase in T- and N-indices (change of stage after neoadjuvant chemotherapy) proved an important prognostic factor. Survival rates correlated with clinical effect and dropped as it diminished.

[Eccrine mucinous adenocarcinoma].

A case of a rare malignant tumour of the sweat glands is reported. Such tumors are often taken for visceral adenocarcinoma metastasis. The tumor was diagnosed by means of immunohistochemistry.

[Endovascular papillary angioendothelioma].

One case of a rare vascular tumor which occurs mainly in the childhood is presented. The tumor has a tendency to recurrence and metastases into the regional lymph nodes in spite of a relatively mature structure.

[Cytological differential diagnosis of different variants of peripheral lung tumors].

Cytological differential diagnostic features of bronchiolo-alveolar carcinoma and papillary adenocarcinoma are established basing on the material of needle biopsies by means of Statistica program. It is found that the strongest influence on the cytological diagnosis of these two tumors is associated with the following pairs of cytological features: lane--clear-cut cell borders and lane--the presence of macrovacuoles.

[Surgical, radiation and combined treatment of multiple primary malignancies of the respiratory system].

Surgery for primary multiple malignant tumors of the respiratory system was carried out in 141 patients. Reconstruction, plastic operations and sparing resections were performed in 79 cases (68.5%).

[Lung cancer: 30-year experience of surgical and combined treatment].

6,212 lung cancer patients have been examined and treated. The data on surgical and combined treatment of 2,702 patients have been analyzed. Postoperative complication incidence has dropped to 5.

[Radiotherapy for cystadenoma of the trachea].

Radiation as a method of treatment was carried out in 16 (25.0%) out of 64 patients with tracheal adenocystoma (radical dosage of 50-70 Gy (12) and palliative--40-48 Gy (4). The dosimetric profile consisted of the cervical, cervico-thoracic, thoracic and bifurcation sections of the trachea.

[Treatment for squamous cell carcinoma of the trachea].

Treatment of squamous-cell tracheal tumors was given to 85 patients. Surgery was carried out in 48 (56.5%), radical resection--22 (25.