Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretome.

Background: Numerous case studies have reported spontaneous regression of recognized metastases following primary tumor excision, but underlying mechanisms are elusive. Here, we present a model of regression and latency of metastases following primary tumor excision and identify potential underlying mechanisms.

Results: Using MDA-MB-231 human breast cancer cells that express highly sensitive luciferase, we monitored early development stages of spontaneous metastases in BALB/c nu/nu mice.

Clinical Proteomics of Breast Cancer Reveals a Novel Layer of Breast Cancer Classification.

Breast cancer classification has been the focus of numerous worldwide efforts, analyzing the molecular basis of breast cancer subtypes and aiming to associate them with clinical outcome and to improve the current diagnostic routine. Genomic and transcriptomic profiles of breast cancer have been well established, however the proteomic contribution to these profiles has yet to be elucidated. In this work, we utilized mass spectrometry-based proteomic analysis on more than 130 clinical breast samples to demonstrate intertumor heterogeneity across three breast cancer subtypes and healthy tissue.

Principles of Systems Biology, No. 31.

This month: selected work from the 2018 RECOMB meeting, organized by Ecole Polytechnique and held last April in Paris.