Publications by authors named "Galen Hostteter"
Article Synopsis
- A somatic mutation in AKT1 (E17K) was identified, which is primarily found in luminal breast cancers and affects cell growth and behavior.
- The research focused on comparing genetically matched non-cancerous and cancerous mammary epithelial cells to understand how E17K influences tumor development.
- Findings revealed that E17K has contrasting effects in different cell types; it inhibits growth in myoepithelial cells but enhances survival and migration in luminal cells, highlighting the role of cellular context in cancer phenotype.
