A quality of life study in 20 adult long-term survivors of unrelated donor bone marrow transplantation.

There are few specific data available concerning quality of life (QOL) of survivors of unrelated donor bone marrow transplantation (UD-BMT). The procedure is expensive, difficult and is being employed increasingly yet we have little information concerning the QOL of survivors to justify this intervention. In this study, 20 long-term (>1 year post-BMT) survivors were studied with four self report questionnaires designed to assess quality of life, satisfaction with life, social support and employment status.

Phase I evaluation of humanized OKT3: toxicity and immunomodulatory effects of hOKT3gamma4.

Murine anti-CD3 (OKT3, Muromonab-CD3) is a potent human T-lymphocyte mitogen. A previous clinical Phase I trial examined OKT3 as an immunomodulator for the treatment of cancer. However, the murine monoclonal antibody triggered a potent humoral response that neutralized the antibody activity during subsequent administration.

Adenosquamous carcinoma of the mouth: a rare variant of squamous cell carcinoma.

Adenosquamous carcinoma is a rare tumour in the oral cavity and is characterised histologically by carcinomatous change in surface epithelium, in association with adenocarcinoma affecting the ducts of minor salivary glands. Only a dozen cases have previously been reported in the oral cavity, but all have shown an aggressive course with 60% of patients dying of disease. We report three further cases and review the literature, which suggests that this lesion should be regarded as a high-grade variant of squamous cell carcinoma.

Combination of chemotherapy with interleukin-2 and interferon alfa for the treatment of metastatic melanoma.

Purpose: The primary objective of this clinical study was to assess the feasibility of administering recombinant interleukin-2 and recombinant interferon alfa-2a before and after combination cytotoxic chemotherapy. After encouraging initial responses, the study was expanded to further evaluate the therapeutic potential, clarify the toxicities of this regimen, and explore any associated immunologic changes.

Patients And Methods: Eighty-four patients with metastatic melanoma, including patients with brain metastases, were treated on this 6-week protocol.

Nursing management of patients with malignant melanoma receiving adjuvant alpha interferon-2b.

As the incidence of melanoma continues to increase, oncology nurses will be caring for more patients receiving adjuvant alpha interferon-2b. Managing the side effects from this therapy requires expert nursing care. The nurse's role throughout the year-long therapy is critical to ensure the patient's continued adherence to the treatment schedule.

Malignant melanoma and adjuvant alpha interferon-2b for patients at high risk of relapse.

Malignant melanoma, the least common but most serious form of skin cancer, is increasing at a faster rate than any other form of cancer. Early diagnosis can lead to cures through surgery alone. Patients with deeper primary lesions (greater than 4 mm) or regional lymph node involvement have a high risk of relapse.

[Left-handedness in dental undergraduates and orthodontic specialists].

A questionnaire was devised involving a group of dental students (n = 70) and a group comprising all consultant orthodontists in the UK (n = 170) to investigate the prevalence and the role of handedness in dental specialisation. Subjects were classified as being pure left-, mixed- or pure right-handed according to responses to a hand preference questionnaire and the results were compared with a very similar previous study of the general population. The prevalence of sinistrality (classified by writing) was recorded as 8.

Left-handedness in dental undergraduates and orthodontic specialists.

A questionnaire was devised involving a group of dental students (n = 70) and a group comprising all consultant orthodontists in the UK (n = 170) to investigate the prevalence and role of handedness in dental specialisation. Subjects were classified as being pure left-, mixed- or pure right-handed according to responses to a hand preference questionnaire and the results were compared with a very similar previous study of the general population. The prevalence of sinistrality (self-classified by writing) was recorded as 8.

Linnik microscope imaging of integrated circuit structures.

Experimental one-dimensional intensity and phase images of thick (>200 nm) oxide lines on silicon are presented together with profiles predicted from the waveguide model. Experimental results were obtained with a purpose-built Linnik interference microscope that makes use of phase-shifting interferometry for interferogram analysis. Profiles have been obtained for both TE and TM polarizations for a wide range of focal positions and in both bright-field [type 1(a)] scanning and confocal modes of microscope operation.

Relief of recurrent upper extremity sympathetically-maintained pain with contralateral sympathetic blocks: evidence for crossover sympathetic innervation?

A case of recurrent right upper extremity sympathetically maintained pain was completely relieved with contralateral sympathetic blocks. Yet Ipsilateral blocks produced no change in pain. Surgical sympathectomy of the contralateral thoracic sympathetic chain produced significant and persistent pain relief.

Chronic ankle instability: the value of talar tilt under general anaesthesia.

Ankle inversion injuries are the most common injury in sport and yet treatment is controversial. One result is chronic ankle instability, an injury for which criteria for surgical intervention are unclear. This prospective study of 14 patients showed that a large proportion of patients had no detectable abnormality on preoperative investigation, but were subsequently shown to have an abnormality under general anaesthesia.

Capillary electrophoresis-electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry for direct analysis of cellular proteins.

The combination of capillary electrophoresis (CE) with electrospray ionization (ESI) mass spectrometry has proven to be broadly applicable to a wide range of biologically important compounds. When combined with Fourier transform ion cyclotron resonance (FTICR) mass spectrometry, the combined method, in addition to high-resolution separations, affords high-resolution precision mass measurements for analytes separated from complex mixtures. Direct chemical analysis of single cells has received considerable attention in recent years; the single cell approach provides a major step toward answering important questions in the field of cellular biochemistry.

Trigeminal neuralgia and multiple sclerosis. A complex diagnosis.

Trigeminal neuralgia is a well-recognized complication in patients with multiple sclerosis. A case report is presented that describes multiple sclerosis in a middle-aged man with otherwise classical unilateral trigeminal neuralgia who demonstrated a variable response to pharmacologic and surgical intervention. The case highlights the difficulties of diagnosis when trigeminal neuralgia occurs concurrently with multiple sclerosis.

Bio-affinity characterization mass spectrometry.

A new approach, bio-affinity characterization mass spectrometry (BACMS), aimed at providing a more rapid, sensitive and potentially more flexible alternative to techniques presently employed for the characterization of noncovalent interactions in mixtures, such as would be encountered in combinatorial chemistry, in presented. BACMS avoids some of the difficulties and potential artifacts associated with affinity chromatography since the noncovalent associations occur in solution; thus, BACMS avoids the requirement of solid support media and the development of non-interfering linker species. This paper describes the conceptual basis for the methodology and its potential use in applications which include the screening of high affinity ligands in support of new drug development.

Effects of neurolytic concentrations of alcohol and phenol on Dacron and Gore-Tex vascular prosthetic grafts.

Background And Objectives: Neurolytic nerve block, using either alcohol (A) or phenol (P), is frequently used to treat intractable pain. However, these agents may disrupt the integrity of prosthetic vascular grafts. To investigate this possibility, the tensile strength of Dacron (Meadox Medicals, Oakland, NJ) and Gore-Tex (W.

Nonlinear-optical studies of molybdenum metal organics.

We have measured the third-order susceptibility, X((3)), versus concentration for a number of molybdenum-based metal-organic complexes in solution, using independent degenerate four-wave mixing and Z-scan techniques. Good agreement was obtained between the degenerate four-wave mixing and Z-scan measurements. The variation of X((3)) with concentration yielded the second-order hyperpolarizability gamma.

Sheathless capillary electrophoresis-electrospray ionization mass spectrometry using 10 mu m I.D. capillaries: analyses of tryptic digests of cytochrome c.

The analyses of tryptic digest of proteins present a difficult challenge to the analytical chemist due to the wide range of molecular masses and hydrophobicities of the peptides produced. In this study, we demonstrate the separation of tryptic digests of bovine, Candida krusei and equine cytochrome c using a new electrospray ionization (ESI) interface for CE-MS that does not require additional sheath make-up fluid or mechanical assistance to aid the ESI process. The utility of this new CE-ESI-MS interface is demonstrated using a 10 microm I.

Metacarpophalangeal pattern profile analysis in Brachmann-de Lange syndrome.

We analyzed the metacarpophalangeal pattern profile (MCPP) of 19 individuals with Brachmann-de Lange syndrome (BDLS) and calculated a mean syndrome profile. Fourteen of 19 individuals with BDLS had significant positive correlations which indicated clinical homogeneity. Discriminant analysis of individuals with BDLS compared with a sample of normal individuals produced a correct classification rate of 100% based on a function of 2 MCPP variables that may provide a useful tool for assisting in the diagnosis of BDLS.