Bone marrow biopsy (BMB). III. Bone marrow biopsy in Hodgkin's disease (HD).

Bone marrow biopsies have been investigated in 330 cases of Hodgkin's disease totalising 298 patients, out of which 32 with repeated biopsies. Positive biopsies with typical lesions were found in 32% of patients, the majority in stages III and IV (88.6%), rarely in stage I or II (11.

Bone marrow biopsy (BMB). II. Bone marrow biopsy in myeloproliferative disorders.

The myeloproliferative disorders (MPD) are a domain in which the bone marrow biopsy (BMB) greatly proved its utility. We have studied the histology of the bone marrow (BM) in all the four entities of MPD: chronic myeloid leukemia (CML) with its subtype, chronic megakaryocytic granulocytic myelosis (CMGM), polycythemia vera (PV), hemorrhagic thrombocythemia (HT) and myeloid metaplasia with myelofibrosis (MMM). The work presents in short some of the clinical and hematologic characters of MPD with special stress upon the histologic modifications of BM, either specific or common to all MPD entities, underlying also the criteria for differential diagnosis.

Bone marrow biopsy (BMB). I. Generalities, material and method, normal structure of bone marrow, pathological conditions.

The authors presented in their first note generalities concerning the normal and pathological structure of bone marrow (BM), based on their personal experience (1,500 BMB) and on the literature. A short historical survey and the adopted research method are presented. The advantage of Burkhardt's myelotomy with its technical process by embedding in synthetic resins to avoid decalcification are discussed.

Angiosarcoma of the breast. A report of three cases.

The histopathologic and clinical features of 3 breast angiosarcomas were presented. The microscopic patterns were heterogeneous, comprising vascular structures in various degrees of differentiation and solid cellular proliferations, the proportion of which varied from tumor to tumor. All 3 tumors were classified in the third group of angiosarcomas.

Ultrasonically guided fine needle aspiration biopsy for the diagnosis of abdominal tumors.

The authors report on the value of ultrasonically guided fine needle (0.6 mm = 23 gauge) biopsy in the morphological diagnosis of abdominal tumors. The method is characterized by a high specificity, resulting from the direct evidencing of the tumoral cells.

Cytophotometric study of DNA content of cells in type III cervical smears.

Cytophotometric study of suspicious (group III of the Papanicolaou's classification) smears shows the heterogeneity of this group, which includes cases with diploid--tetraploid DNA modes, cases with a wide distribution of DNA values and aneuploid cases. The significance of these findings in relation with the biological properties of cells is briefly discussed.

Tubular carcinoma of the breast.

Forty-six tubular carcinomas selected from a series of 434 breast cancers, operated by radical mastectomy, were classified in four types: pure tubular carcinoma--one case, and three mixed types of tubular carcinoma in which the tubular structures decrease progressively in favour of a trabecular, poorly differentiated component. The tumors size and regional lymphatic dissemination increased in parallel with this dynamic change of parenchyma. Tubular carcinoma metastasized less frequently and in lower number of axillary lymph nodes as the other types of invasive breast tumors.

The lymphoblastic lymphoma: a clinical and morphological entity, two new cases.

There are reported two new cases of lymphoblastic lymphoma in an 8 and a 12 year-old child respectively. The diagnosis is based on cytological features, similar or identical to those of acute lymphoblastic leukemia, the presence of a mediastinal growth and a rapid evolution, and with an early involvement of the bone marrow. The cytohistological pattern was dominated in one case by the proliferation of immature lymphocytes with convoluted nuclei, and in the second one by immature lymphocytes with round nuclei.

Elastosis in breast carcinoma.

Elastosis, the significant increase of elastic tissue, was identified by histochemical methods in 45 (53.5%) cases of an unselected series of breast cancers. They were all invasive ductal carcinomas with or without tubular differentiation.

Hematologic and histologic experimental investigations on the therapeutic effect of leukotrophin.

The paper aims at evidencing the stimulating effect on hematopoietic stem cells exerted by the thymus extract "Leukotrophin", prepared by Ellem Laboratory, Milan, Italy. Investigation of the hematologic and histologic parameters allowed the follow up of alterations occurring in bone marrow, blood and tissues of the irradiated animals, treated and untreated as compared with the unirradiated and untreated controls. Regeneration was more active in the groups of animals irradiated and treated with Leukotrophin than in the irradiated and untreated controls.

Diagnostic value of chromosome examination in effusions from cancer patients.

Fifty nine effusions (6 from patients with benign diseases and 53 from cancer patients) were examined cytologically and cytogenetically. Only diploid cells were observed in the benign effusions. The majority of malignant effusions had chromosomal changes, but in three cases where cytologic examination had revealed the presence of malignant cells, only diploid metaphases were found.