[Dynamics of driven rhythm in neuron in sensorimotor cerebral cortices in rabbit on electrodermal paw stimulation].

The dominant centre is a zone of proof higher excitation of neurons in the cortex of the brain, resulting from long stimulation or effector (in our case of a forepaw of an animal) or direct cortical representations of this effector. Besides of higher excitation and the firmness of excitation neurones, the dominant centre has two more very important properties--ability to summation (addition) coming to a cortex and extending on cortical neural networks excitations and inertia. Last property is shown what even in some days after the termination of the stimulations which have formed a dominant, in reply to testing stimulus (earlier indifferent for an animal) the centre is activated and puts in action effector.

[Time and space distribution of coincident impulses in closed neural circuits in the sensorimotor cortex of the rabbit (the rhythmical defensive dominanta)].

In the course of analysis of the conjugate unit activity of simultaneously recorded neurons in the sensorimotor cortex of rabbits, 22 closed neural circuits consisting of 3 or 4 neurons were considered. In the model of the defensive dominanta, 1-3 weeks after imposing rhythmic (2 s) activity to a rabbit, the distribution of coincident impulses was analyzed in real time. It was found out that the events when the coincident impulses of neural pairs were generated with two-second intervals could be shifted in time and space over a closed circuit of neurons in one direction.

[Cortical network activity before behavioral reaction and before its omission in rabbits with defensive dominanta].

Defensive dominanta was formed in rabbit CNS. Activity of the cortical neuronal network was investigated in these rabbits in the state of quiet wakefulness and in the intervals between the presentations of testing stimulus (light flashes). Statistical analysis of spike trains revealed some distinctions in neuronal functional organizations in the excitation focus (sensorimotor cortex) and in the visual cortex in the states of quiet wakefulness, before the movement of the paw, and before the omission of the reaction.

[Dynamics of driven rhythm in neuronal assemblies in sensorimotor and visual cerebral cortices in rabbit].

Coincident activity of pairs of neurons in the sensorimotor and visual areas of the cerebral cortex was studied in naive, learning, and trained rabbits during the formation of a hidden excitation focus in their central nervous system (a defensive dominanta) of the rhythmic nature. In the trained rabbits (as compared to the naive animals), percent of neuronal pairs (both neighboring and distant) in whose coincident activity the rhythm of stimulation prevailed was higher. In the visual cortex, percent of such pairs was significantly higher only for the distant neurons.

[Neuronal correlates of changes in the time parameters of motor reactions in rabbits after tonic immobilization].

The latent excitation focus in the sensorimotor cortex of rabbits was formed by a series of pulses of the threshold current applied on a paw with 2-second intervals. After repeated applications of the routine immobilization procedure, besides the 2-second starts of the paw in response to testing stimulus, spontaneous starts appeared with the intervals close to 3 and 4 seconds. The analysis of the coincident (interconnected) activity of pairs of nearby neurons in the sensorimotor cortex of three rabbits repeatedly exposed to the immobilization procedure showed that (a) in situations when animals made movements with the intervals of 2 seconds, the 2-second rhythm prevailed in the coincident activity of neurons; (b) during movements made with the 3-second interval, a 3-second rhythm was more frequently revealed in the coincident activity of cells, (c) in the situations when the animals did not make movements, either 2-, or 3-second rhythms were equiprobably observed in the connected activity of nearby neurons.

Correlations between neuron activity in the sensorimotor cortex of the right and left hemispheres in rabbits during a defensive dominant and "animal hypnosis".

A latent focus of excitation with a rhythmic nature (a defensive dominant focus) was created in the CNS of rabbits. The focus was formed by threshold electrocutaneous stimulation of the left forelimb using series of impulses consisting of 15-20 stimuli with interstimulus intervals of 2 sec. The linked activity of cells in the sensorimotor cortex of the right and left hemispheres was analyzed.

[Correlations of activity of neurons of sensorimotor cortex of the right and left brain hemispheres of rabbits during defensive dominant and "animal hypnosis"].

A hidden excitation focus of the rhythmic nature (a rhythmic defensive dominant focus) was produced in the rabbit's CNS. The focus was formed by means of threshold electrodermal stimulation of the left forelimb by series of pulses consisting of 15-20 stimuli with 2 s intervals between the pulses. Correlated activity of cells in the sensorimotor cortex of the right and left brain hemispheres was analyzed.

Linked activity of neurons in the sensorimotor cortex of the rabbit in the state of a defensive dominant and "animal hypnosis".

A cryptic focus of excitation (a dominant focus) was created in the brains of rabbits by threshold stimulation of the left limb with a current at a frequency of 0.5 Hz. After creation of a focus, there were equal probabilities of detecting pairs of neurons whose linked activity was dominated by a 2-sec rhythm in the sensorimotor cortex of both the right and left hemispheres (29.

[Correlated activity of neurons in the sensorimotor cortex of rabbits in the state of defensive dominanta and "animal hypnosis"].

A hidden excitation focus (dominanta focus) was produced in the rabbit's CNS by threshold electrical stimulation of the left forelimb with the frequency of 0.5 Hz. As a rule, after the formation of the focus, pairs of neurons with prevailing two-second rhythm in their correlated activity were revealed both in the left and right sensorimotor cortices (with equal probabilities 29.

Effects of "animal hypnosis" on a rhythmic defensive dominant.

A defensive dominant was created in rabbits using rhythmic electrocutaneous stimulation of the left forelimb at a frequency of 0.5 Hz. After stimulation ended, the latent excitation state was tested using sound stimuli.

[Influence of "animal hypnosis" on intersignal movements of rabbits during rhythmical defensive dominant].

Defensive dominanta was produced in four rabbits with electrodermal rhythmic stimulation of the left fore paw with the frequency of 0.5 Hz. During testing the dominanta with acoustical stimuli, the paw muscles responded with either a decrease in its non-rhythmic activity or rhythmic quiver with the frequency close to that of electrodermal stimulation.

[Effect of "animal hypnosis" on the rhythmic defensive dominanta].

A defensive dominanta (stationary excitation focus) in the sensorimotor cortex of rabbits was formed by rhythmical electrodermal paw stimulation with the frequency of 0.5 Hz. After cessation of the stimulation, the state of hidden excitation was tested with acoustic stimuli, in response to which nonrhythmic activity of leg muscles increased or the leg rhythmically startled with the frequency close to that of the electrodermal stimulation.

Correlated activity of sensorimotor cortex neurons in the left and right hemispheres of the rabbit brain in immobilization catatonia.

Spike sequences extracted from multineuron activity from neurons in the sensorimotor cortex, and recorded simultaneously in the left and right hemispheres of the brains of rabbits in the state of immobilization catatonia ("animal hypnosis") and on recovery of animals from this state were analyzed. Cross-correlation analysis of spike flows revealed a temporal relationship between the appearance of neuron spikes in the left and right hemispheres; these were regarded as the mutual influences of these neurons on each other. The intensity of the influences of left hemisphere neurons on cells in the right brain was shown to change significantly in relation to baseline measures at all stages of the experiment and at all of the time points studied.

Structure of dependent relationships between neurons in the sensorimotor cortex of the left and right hemispheres in rabbits in immobilization catatonia.

Dependence in the activity of sensorimotor cortex neurons recorded simultaneously in the left and right hemispheres was detected in rabbits in baseline conditions, during the state of immobilization ("animal hypnosis"), and recovery of animals from this state. In baseline conditions, the total percentage of dependent relationships between close-lying (within 50 microm) neurons in the left hemisphere was significantly smaller than in the right hemisphere and did not change either in the state of immobilization or on recovery from it. The total percentage of dependent relationships between close-lying neurons in the right hemisphere decreased significantly during immobilization and returned to baseline levels on recovery from this state.

[Breathing patterns peculiarities as the index of the "animal hypnosis" state in the rabbit].

Breathing patterns were recorded during "animal hypnosis" in seven Chinchilla rabbits. The state of "animal hypnosis" was evoked by the hand pressure on the thorax and the waist of a rabbit. Breathing pattern was recorded by means of an elastic coal-powder element that was set round the rabbit's thorax.

[The structure of dependent relationship between neurons in the sensorimotor cortex of the left and right hemisphere in rabbits during immobilizing catatonia].

Relations between activities of neurons simultaneously recorded in the left and right sensorimotor brain cortices of rabbits were analyzed in a series of experiments before the induction of the immobilization state ("animal hypnosis"), in the state of immobilization, and after its termination. The total baseline percent of significant correlations between activities of neighboring (within 50 microns) neurons in the left hemisphere was significantly lower than in the right hemisphere. This characteristic of the left hemisphere changed neither in the immobilization state nor after its termination.

Comparative analysis of the frequency of neuron spike activity in the sensorimotor cortex of the right and left hemispheres in conditions of immobilization catatonia in rabbits.

Multineuron activity was recorded from the sensorimotor cortex of the right and left hemispheres during immobilization catatonia in rabbits. The first session of immobilization of the animals was followed by changes in spike frequency in 47% of neurons in the sensorimotor cortex of the right hemisphere. Of these, 30% showed decreases in spike frequency and 17% showed increases.

["Animal hypnosis" and defensive dominant, behavioral aspect].

A stationary excitation focus produced in the sensorimotor cortex of a rabbit by rhythmic electrodermal paw stimulation was manifested in the reaction to a testing sound stimulus earlier indifferent for the animal. Regardless of the stimulated paw (left or right), reactions to the testing stimuli appeared approximately in the equal percent of cases (70.7% and 71.

[Comparative analysis of discharge frequency of right and left sensorimotor cortical neurons in rabbits during tonic immobility].

Multiunit activity was recorded in left and right sensorimotor cortex of rabbits in the state of tonic immobility. After the first immobilization session, the discharge frequency changed in 47% cells in the right hemisphere: 30% decreased their frequency, and 17% increased. In the left hemisphere, only 18% cells changed their discharge frequency (13% decreased and 5% increased).

Analysis of the linked spike activity of pairs of neurons in cortical microstructures.

Three behavioral models were used to analyze the dynamics of linked spike activity of pairs of simultaneously recorded cortical neurons. These experiments showed that the time distribution of linked cell activity can encode the parameters of the stimuli used.

[Estimation of the interaction strength in the rabbit sensomotor cortex neurons before and after formation of the defense focus].

The strength of interaction between neurons in the sensorimotor cortex of rabbits was compared before and after the formation of a hidden excitatory focus (dominant) in this cortical area. In control experiments the interactions between the neurons was significantly stronger in cases when the influence of the neurons with higher spike amplitude on the neurons generating lower-amplitude pulses was assessed. This difference disappeared in the dominant focus.

[Analysis of the simultaneous discharges of neuron pairs in the brain cortical microstructures].

Dynamics of simultaneous discharges of pairs of cortical neurones was studied in three behavioural conditions. Parameters of the stimulation applied was shown to be encoded in trains of simultaneous unit discharges.

[The transmission of coded information over neuronal systems exemplified by the motor rhythmic dominant].

Functional organization of neurons in rabbit's sensorimotor cortex was studied before and within several days after formation of the rhythmical dominant focus. Functional reorganization of neurons in cortical microareas took place during actualization of the dominant. The number of functional interneuronal relations within neuronal pairs of a certain type could be increased in comparison with the control values and decreased within pairs of another type.

The time distribution of linked spike activity of rabbit sensorimotor cortex neurons in the presence of a rhythmic motor dominant.

The existence of a cryptic stationary focus of excitation induced in the cortex by rhythmic electrical stimulation of the paw was detected using sound test stimuli which were previously indifferent to the experimental animals. Neuron activity was recorded in the sensorimotor cortex of rabbits. Neuron pairs were identified which operated in a correlated fashion in the dominant focus.

[The time distribution of the spike train activity of the neurons in the rabbit sensorimotor cortex during a rhythmic motor dominant].

A stationary excitation focus produced in rabbit cortex by rhythmical electrodermal paw stimulation was revealed by presentation of testing sound stimuli, which were earlier indifferent for an animal. The multiunit activity in the sensorimotor cortex was recorded. The neuronal pairs were detected with correlated discharges.