[Search for biochemical factors implicated in the pathogenesis of alcoholism in different ethnic populations].

A Chukotka indigenous population (the Chukchis, Eskimos) craving alcohol was examined. Changes in the levels of endogenous ethanol (EE) and its relation to calcium homeostasis, hypophyseal-adrenocortical hormones (stress) in the body are regarded as a possible role in alcohol motivation and ethanol dependence. The frequency and pattern of alcohol consumption, high alcoholism incidence rates in the family history may consider the Arctic Mongoloids as a group at high risk for alcoholism.

[Rationale for alcohol consumption and mitochondrial aldehyde dehydrogenase genotype in the native male population of Chukotka].

To study the alcohol consumption pattern and mitochondrial aldehyde dehydrogenase (ALDH2) genotype, a random sample consisting of 170 native males (Chukchee and the Eskimo), residents of 4 Chukotka settlements, was studied. According to interviews, most residents (68%) consumed alcohol once or twice a month; however during an alcohol uptake episode they consumed very high (intoxicating) doses exceeding 150 g of pure alcohol. The rates of control loss, alcohol amnesia and withdrawal syndrome were more than 50%.

[Various results of the study of medico-biological aspects of alcoholism in Siberia and Far East].

To study the dynamic changes in alcohol abuse, a new methodological approach has been developed which implies staged realization. Stage one was aimed at the search for integral clinical-dynamic characteristics as well as social and psychological properties to make identification of the clinical phenotype reliable. Stage II--at introduction of integral constitution-morphology indicators representative of the disease predisposition-stability.

[Helminthiases among the population of northwestern Siberia. 1. Opisthorchiasis and mixed invasion in the native inhabitants of the Ob River basin and their clinical course].

The use of multifactor statistic analysis for screening population of the northern part of the Ob river basin for helminthiasis allowed the authors to reveal a significant feedback between manifested opisthorchiasis and other types of this disease course in both sexes. The main component analysis indicates that the tentatively control group of males is presented by adolescents (14-17 years old) who are likely to be infected with Opisthorchis without evidence of its clinical manifestations. The correlation analysis demonstrated also a direct relationship between the age and manifest opisthorchiasis, as well as double mixed invasion of males (r-0.

[Multifaceted analysis of the interactions of morphophysiologic signs and ischemic ECG changes (a population study)].

Relationships between serum lipid and lipoprotein levels, arterial blood pressure, body weight and age, on the one hand, and coronary heart disease (CHD), on the other, were investigated by means of the main constituents analysis in a Northern Khant population. The pattern of relationship between the parameters in question was similar, by the first main constituent, in males and females, and suggested their age-dependence, unrelated to CHD. The second constituent, as a sum total of the effects of another factor, showed an unbalance between body weight and blood lipids, which was correlated with CHD in males and remained indifferent with respect to CHD in females.

[Complex medico-genetic study of the population of western Siberia. III. Distribution of phenotypes and gene frequencies in the northern Khanty population].

Distribution of phenotypes and gene frequencies for 5 polymorphic loci as well as frequencies of incidence of some anthroposcopic parameters in five subpopulations of the North Khanty population is presented. A comparative analysis was performed for the traits studied among the people of Finno-Ugric group and of North Asia. Wahlund's variance values point to significant subdivision of the population in question.

Sole dermatoglyphics in the Forest Nentsy, Nganasans, and Chukchi: dermatoglyphic distances.

Sole dermatoglyphics of the aborigines of Northwestern Siberia, Taimir, and Kamchatka are presented in this paper. The distance coefficients based on various combinations of dermatoglyphic traits depending on their heritability were estimated. These were compared with the overall dermatoglyphic distance coefficients as well as with the genetic (dermatoglyphic) distance coefficients based on six blood groups (ABO, MNSs, P, Fy, Jk, Kp).

[Genetic structure of an isolated group of the indigenous population of northern Siberia--Nganasans (Tavgiitsi) of Taymyr. I. History, erythrocyte and serum blood systems, isoenzymes].

Nganasans is a small samodyen-speaking ethnic group originated from several clans of reindeer hunters. Pedigree studies revealed no consanguineous matings of uncle-niece, aunt-nephew, first cousins type among 120 families studied. Rather rarely mating between second cousins could be observed.