Clustered breast microcalcifications: evaluation by dynamic contrast-enhanced subtraction MRI.

Objective: Our goal was to evaluate dynamic contrast-enhanced subtraction MRI in the diagnosis of isolated clustered calcifications of the breast.

Materials And Methods: One hundred seventy-two patients underwent surgical biopsy for isolated clustered breast calcifications. Their mammograms showed round (n = 88) or linear/irregular (n = 84) microcalcifications.

[Porphyria variegata. Apropos of a case].

A patient hospitalized because of somatic disturbances without any sign of detectable cerebral organicity and because of secondary anxiety disorder and major depression presents different clinical pictures with a neurological aspect. All this pictures, that evoke the diagnostic of hysteria conversion in particular, are complicated by a tetraplegia with emission of red urine that enable us to think of a diagnostic of hepatic-porphyria (variegata). Hereditary metabolic diseases, which categories of bioclinic symptoms (that enable us to evoke the diagnostic and to prevent the complications that are breeded by the prescription of forbidden drugs for ill subject) are reminded.

[Prevalence of ragweed hayfever in the south and east of the greater Lyon region in 1993].

In December 1993, AFEDA conducted an epidemiological survey in order to establish the prevalence of ragweed-induced pollinosis and to evaluate how well the public was informed about this danger. A survey by telephone was made, taking a random sample of the population drawn by lot from telephone directories in the Rhône district. This involved about 300,000 homes.

[Diagnosis of non-palpable breast lesions: contribution of cytological punctures after stereotaxic localization].

The authors reviewed the accuracy of stereotaxic fine-needle aspiration cytology. Two hundred-twenty-eight lesions were studied: 103 benign lesions, 125 cancers. Inadequate sample was obtained in 26% of cases.

Quality of life and insomnia validation study for a specifically designed questionnaire.

A questionnaire was devised to assess changes in the quality of life of insomniac patients when treated by a hypnotic. The questionnaire was validated in two groups of patients (60 non-insomniac and 52 insomniac patients). The results of this study confirmed the relevance of the questionnaire and its power to distinguish between the two groups of patients.

Primary lymphoma of the ovary. A case report and critical review of the literature.

Primary lymphoma of the ovary is an extremely rare cause of ovarian mass. Few cases have been recorded in English literature, and controversy still exists as to the existence of such an entity. We present a case whose diagnosis can be supported by rigorous diagnostic criteria--a long follow-up after surgery with only one course of adjunctive polychemotherapy.

Correlates of somatic causal attributions in primary care patients with fatigue.

Researchers in the field of chronic fatigue in tertiary care found that patients' somatic (e.g. viral) explanations for their condition may lead to chronicity of symptoms.

The prevalence of adenomyosis and endometriosis in an ultra-religious Jewish population.

In view of increasing incidence of adenomyosis and endometriosis reported in recent years, we evaluated the incidence of these disorders in a unique ultra-orthodox Jewish population over the past 20 years by reviewing 1,434 hysterectomy specimens. The incidence of adenomyosis among the hysterectomy specimens decreased from 15.14% in the first 10 years of the period studied, to 9.

Low dose ketoconazole attenuates serum androgen levels in patients with polycystic ovary syndrome and inhibits ovarian steroidogenesis in vitro.

Objective: To investigate the effects of a low-dose ketoconazole on ovarian steroidogenesis and on serum androgen levels in polycystic ovary syndrome (PCOS).

Design: In vitro, human granulosa-luteal cells were incubated with ketoconazole and radiolabeled steroid substrates, to follow their metabolic fate by thin-layer chromatography analysis. In vivo, normally cycling women (n = 7) in their luteal phase were administered one tablet of 200 mg ketoconazole at 8 A.

Side effects of ovarian hyperstimulation: hormonal and lipid profile changes.

Objective: Ovarian hyperstimulation is associated with a significant increase in ovarian steroid hormone production. Since such high levels of sex steroids may influence the activity of other endocrine glands, as well as affecting lipid metabolism, we studied the effect of ovarian hyperstimulation on the hormonal and lipid profile.

Study Design: In ten patients who were treated with human menopausal gonadotropins (hMG) for in vitro fertilization (IVF), the serum levels of dehydroepiandrosterone (DHEA), 17-hydroxyprogesterone, insulin, cortisol, growth hormone, thyroid-stimulating hormone, and prolactin, as well as total cholesterol, low-density-lipoprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol (HDL-C), triglycerides, and free fatty acids were monitored.

Quality of life after the menopause: influence of hormonal replacement therapy.

Objective: Our purpose was to demonstrate the clinical efficacy and effect of hormone replacement therapy in menopause on quality of life.

Study Design: A randomized, open, 6-month comparison of hormone replacement therapy (estradiol transdermal system [Estraderm TTS] plus chlormadinone) and symptomatic treatment (verapipride) was performed. Analysis was by intention to treat.

Mammographic features of 455 invasive lobular carcinomas.

Of 6,009 cases of breast cancer studied, 455 (7.6%) were invasive lobular carcinoma (ILC); 341 of these (75%) were pure ILC and 114 (25%) were ILC mixed with ductal forms. The mammographic features were compared with those of the 5,554 other breast carcinomas.

[Clinical study of EMLA analgesic cream in pediatric locoregional anesthesia].

The advantage of EMLA cream for regional blocks (spinal or caudal blocks) was assessed in 46 children. The study included three groups: group 1, with 1 to 6 month-old children (n = 11); group 2, with children aged between 6 months and 5 years (n = 21), scheduled for emergency surgery and with full stomach; group 3, with 5 to 10 year-old children (n = 14), who were to have a regional block as an alternative to general anaesthesia. The cream was applied as a thick layer on the area of skin to be anaesthetised and covered by a closed adhesive dressing, approximately 2.

[EMLA analgesic cream for venopuncture during anesthetic induction in children].

A prospective study was designed to assess the quality of skin analgesia provided by the EMLA anaesthetic cream, an eutectic mixture of local anaesthetics (prilocaine and lidocaine). The children, aged 3 months to 15 years, and scheduled for genital and urinary surgery, were allocated to two groups, those aged less than or equal to 5 years (35 +/- 14 months, n = 17), and those aged greater than 5 years (97 +/- 26 months, n = 22). The cream (1.

Effect of ketoconazole on steroidogenic human granulosa-luteal cells in culture.

Ketoconazole (KCZ), a widely used antifungal drug, has been reported in humans to inhibit adrenal and testicular steroidogenesis by interfering with the cytochrome P-450-dependent enzymes. The purpose of this study was to investigate the drug effect on steroidogenic human granulosa-luteal cells, obtained by follicular aspiration from mature follicles of gonadotropin-treated women. Cells were cultured in long-term monolayers, and the steroid production was assayed by radioimmunoassay.

The effect of disopyramide on uterine contractions during pregnancy.

To evaluate the effect of disopyramide on uterine contractions during pregnancy, the drug was given for 48 hours to 10 women with indications for labor induction. Placebo was given to 10 other women with the same indications for induction. During the study period, regular uterine contractions occurred in 10 women in the study group, as compared with none in the control group (p less than 0.

[The value of preoperative location of microcalcifications without palpable breast tumors].

In 1986 and 1987, 224 patients were operated on for microcalcification without palpable lesions of the breast. Classical orthogonal (perpendicular grid) localisation was performed in 123 patients: external cutaneous localisation of the nipple was performed in 78 patients and hook localisation in 25 patients. Primary excision without the need for re-excision was possible respectively in 88% and 94% with external and hook localisation and in 83% after orthogonal localisation.