Fndc5/irisin is regulated by myogenesis stage, irisin, muscle type and training.

Objectives: Irisin, a novel myokine that responds to exercise, was initially identified as a regulator of fat tissue metabolism. We aimed to investigate fibronectin type III domain-containing protein 5 (Fndc5)/irisin, auto/para-crine role in different muscle fibers, different activities, and muscle cell differentiation.

Methods: Using , , and muscle models, Fndc5 was studied at the physiological and molecular levels.

A prediction-focused approach to personality modeling.

In the current study, we set out to examine the viability of a novel approach to modeling human personality. Research in psychology suggests that people's personalities can be effectively described using five broad dimensions (the Five-Factor Model; FFM); however, the FFM potentially leaves room for improved predictive accuracy. We propose a novel approach to modeling human personality that is based on the maximization of the model's predictive accuracy.