Publications by authors named "Gaiting Liu"
Target identification is crucial for drug screening and development because it can reveal the mechanism of drug action and ensure the reliability and accuracy of the results. Chemical biology, an interdisciplinary field combining chemistry and biology, can assist in this process by studying the interactions between active molecular compounds and proteins and their physiological effects. It can also help predict potential drug targets or candidates, develop new biomarker assays and diagnostic reagents, and evaluate the selectivity and range of active compounds to reduce the risk of off-target effects.
View Article and Find Full Text PDFArticle Synopsis
- Head and neck squamous cell carcinoma (HNSCC) has a high recurrence rate and low survival, leading to poor patient quality of life, but SM-1, derived from PAC-1, could be effective in enhancing treatment outcomes.
- This study analyzed the effects of SM-1 on HNSCC cell lines using various methods, discovering that it not only inhibited cell growth but also worked better than other treatments when combined with radiation.
- Results indicated that SM-1 causes G2/M phase cell cycle arrest and apoptosis by activating caspase-3, suggesting its potential as a radiosensitizer for HNSCC in future clinical trials.
DNA repair is strongly associated with tumor resistance to radiotherapy and chemotherapy. WD repeat and HMG-box DNA binding protein 1 (WDHD1) is a key adaptor for homologous recombination repair of DNA, and its overexpression is relevant to the poor prognosis of many tumor patients. We previously have identified and validated bazedoxifene (BZA), which had 60% inhibitory rate on WDHD1 in MCF7 cells at 10 μM, from the Food and Drug Administration-approved compound library.
View Article and Find Full Text PDF