Sequential Bilateral Peripheral Nerve Stimulation of Lumbar Medial Branches Following Laminectomy: A Case Report.

In a patient with a history of lumbar spine surgery, the management of refractory low back pain may prove challenging. Advancing neuromodulatory techniques and technologies offer the promise of significant and sustained relief in these patients, though prior literature is limited. We present a case of peripheral nerve stimulation at the lumbar medial branches in a woman with chronic axial low back pain following a three-level laminectomy.

Prediction of Kidney Allograft Discard Before Procurement: The Kidney Discard Risk Index.

Objectives: There is an 18.9% discard rate among kidney allografts. Here, we aimed to determine predictors of kidney discard and construct an index to identify high-probability discard kidney allografts prior to procurement.

A signal-based method for finding driver modules of breast cancer metastasis to the lung.

Tumor metastasis is mainly caused by somatic genomic alterations (SGAs) that perturb pathways regulating metastasis-relevant activities and thus help the primary tumor to adapt to the new microenvironment. Identifying drivers of metastasis, i.e.

An exact algorithm for finding cancer driver somatic genome alterations: the weighted mutually exclusive maximum set cover problem.

Background: The mutual exclusivity of somatic genome alterations (SGAs), such as somatic mutations and copy number alterations, is an important observation of tumors and is widely used to search for cancer signaling pathways or SGAs related to tumor development. However, one problem with current methods that use mutual exclusivity is that they are not signal-based; another problem is that they use heuristic algorithms to handle the NP-hard problems, which cannot guarantee to find the optimal solutions of their models.

Method: In this study, we propose a novel signal-based method that utilizes the intrinsic relationship between SGAs on signaling pathways and expression changes of downstream genes regulated by pathways to identify cancer signaling pathways using the mutually exclusive property.